- Sandhya Nallamotu: Department of Medicine, Kasturba Medical College, Manipal, Manipal, IND.
- Mahith S Reddy: Department of Medicine, Kasturba Medical College, Manipal, Manipal, IND.
We present a rare case of an immunocompetent 49-year-old male agriculturalist from India diagnosed with pneumonia. species are ubiquitous gram-positive, partially acid-fast bacilli that predominantly infect immunocompromised individuals. Only 0.3% to 2.9% of all nocardiosis cases are attributed to . The patient presented with a 25-day history of wet cough and high-grade fever, with bilateral bronchial breath sounds on chest auscultation and findings consistent with pneumonia on chest X-ray. During hospitalization, multiple treatment revisions were made. On admission, empiric antibiotic therapy against community-acquired pneumonia was initiated. Later, GeneXpert sputum testing for complex (MTBC) was positive for MTBC DNA. Suspected tuberculosis with a secondary infection prompted a treatment switch to antitubercular therapy (ATT) along with meropenem. Despite changes to treatment, the patient continued to deteriorate with no signs of clinical improvement. ATT with meropenem was discontinued when a repeat GeneXpert for MTBC was negative, ruling out tuberculosis. Slow-growing bronchial wash culture identified the rare pathogen , prompting an urgent referral to a specialized Infectious Diseases team. Treatment was then tailored according to antibiotic resistance-sensitivity testing. Targeted multidrug antibiotic therapy with trimethoprim-sulfamethoxazole and amikacin against facilitated gradual clinical improvement. This case underscores the importance of considering uncommon pathogens in differential diagnosis and highlights the critical role of microbiological diagnostics in guiding effective treatment. Drug resistance and changing bacterial pathogenicity trends must not be overlooked. The round-about antibiotic treatment changes in this case point to the necessity for faster diagnostic methods in identifying species. Further research into rapid diagnostic methods and up-to-date treatment guidelines are warranted to optimize outcomes in nocardiosis management.