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Aug 29, 2024;15 (9):

Genomic Regions Associated with Growth and Reproduction Traits in Pink-Eyed White Mink.

Hongyu Shi, Linling Liu, Peter Foged Larsen, Yu Ding, Tietao Zhang, Haihua Zhang, Zongyue Liu
Author Information
  1. Hongyu Shi: Jilin Provincial Key Laboratory for Molecular Biology of Special Economic Animals, Key Laboratory of Special Economic Animal Genetic Breeding and Reproduction, Ministry of Agriculture, Institute of Special Economic Animal and Plant Sciences, The Chinese Academy of Agricultural Sciences, Changchun 130112, China.
  2. Linling Liu: Jilin Provincial Key Laboratory for Molecular Biology of Special Economic Animals, Key Laboratory of Special Economic Animal Genetic Breeding and Reproduction, Ministry of Agriculture, Institute of Special Economic Animal and Plant Sciences, The Chinese Academy of Agricultural Sciences, Changchun 130112, China.
  3. Peter Foged Larsen: Jilin Provincial Key Laboratory for Molecular Biology of Special Economic Animals, Key Laboratory of Special Economic Animal Genetic Breeding and Reproduction, Ministry of Agriculture, Institute of Special Economic Animal and Plant Sciences, The Chinese Academy of Agricultural Sciences, Changchun 130112, China.
  4. Yu Ding: College of Animal Science, Jilin University, Changchun 130062, China.
  5. Tietao Zhang: Jilin Provincial Key Laboratory for Molecular Biology of Special Economic Animals, Key Laboratory of Special Economic Animal Genetic Breeding and Reproduction, Ministry of Agriculture, Institute of Special Economic Animal and Plant Sciences, The Chinese Academy of Agricultural Sciences, Changchun 130112, China.
  6. Haihua Zhang: Colleges of Animal Science, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China.
  7. Zongyue Liu: Jilin Provincial Key Laboratory for Molecular Biology of Special Economic Animals, Key Laboratory of Special Economic Animal Genetic Breeding and Reproduction, Ministry of Agriculture, Institute of Special Economic Animal and Plant Sciences, The Chinese Academy of Agricultural Sciences, Changchun 130112, China.
PMID: 39336733 DOI: 10.3390/genes15091142

Abstract

In mink breeding, balanced selection for growth and reproductive features is essential because these traits are contradictory. The variables of total number born (TNB), number born alive (NBA), and body weight (BW) are highly valuable in terms of their importance in mink production. A comprehensive understanding of the molecular mechanisms that drive these features could offer vital insights into their genetic compositions. In the present study, the single-nucleotide polymorphism (SNP) genotypes of 219 minks were obtained via double digest restriction-site associated DNA sequencing (ddRAD-seq). Following several rounds of screening, about 2,415,121 high-quality SNPs were selected for a genome-wide association study (GWAS). The GWAS was used to determine BW and reproductive traits in pink-eyed white mink. It was suggested that , , and serve as potential genes for the total number of kits born (TNB), while , , , , , and are key genes for the number born alive (NBA). Moreover, , , , and are possible BW genes based on association results and available functional data from gene and mammalian phenotype databases. These results offer essential information about the variety of mink and theoretical principles for applying mink breeds.

Keywords

body weight genome-wide association study mink number born alive single-nucleotide polymorphism total number born

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Grants

  1. CAAS-ASTIP-ISAPS-2024/Engineering of Scientific Innovation of the Chinese Academy of Agricultural Sciences

MeSH Term

Animals
Mink
Polymorphism, Single Nucleotide
Reproduction
Genome-Wide Association Study
Body Weight
Female
Quantitative Trait Loci
Male
Genotype
Phenotype
Breeding
Journal Article

Word Cloud

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