Six Myths and Misconceptions about Essential Tremor.

Elan D Louis
Author Information
  1. Elan D Louis: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ORCID

Abstract

There are myths and misperceptions about most human diseases, and neurological diseases are no exception. In many instances, myths and misconceptions reflect what is no more than the collective failure of the field to catch up with the state of the science in that field. Hence, one may perhaps refer to these as "lags" rather than myths. As the field of medicine attempts to be evidence-based, it is best to remain true to published data and the state of the science. In this paper, I review six myths and misconceptions about ET. Myth 1 relates to the natural history and prognosis of ET. Myths 2 and 3 relate to the biological basis of ET, whereas myths 4 and 5 relate to the expression of the core clinical feature of ET. Finally, myth 6 focuses on the issue of disease classification. The myths are as follows: "ET is not associated with a shorter life expectancy". "The pathophysiology of ET remains unclear". "There have also been studies that do not show any cerebellar degeneration". "ET is a postural or a kinetic tremor". "Action tremor in ET is usually bilateral and symmetric". "ET plus". As neurologists, we are not ignorant of feedback loops. A regular review of facts should help to frame one's output. As such, one's formulations and output will be firmly grounded in data.

Keywords

References

  1. Rev Neurol. 2023 Jun 16;76(12):391-398 [PMID: 37303101]
  2. J Neurol. 2005 May;252(5):570-4 [PMID: 15778813]
  3. Tremor Other Hyperkinet Mov (N Y). 2015 May 27;5: [PMID: 26056611]
  4. Mov Disord. 2014 Apr;29(4):496-500 [PMID: 24532134]
  5. J Neurol Sci. 2022 Apr 15;435:120204 [PMID: 35279635]
  6. Expert Rev Neurother. 2024 Aug;24(8):799-814 [PMID: 39016323]
  7. Toxins (Basel). 2017 Nov 10;9(11): [PMID: 29125566]
  8. Front Neurol. 2021 Dec 16;12:782694 [PMID: 34975736]
  9. Arch Neurol. 1998 Dec;55(12):1553-9 [PMID: 9865800]
  10. N Engl J Med. 2018 Aug 09;379(6):596-597 [PMID: 30089076]
  11. Cerebellum. 2021 Dec;20(6):904-912 [PMID: 33768479]
  12. Arch Neurol. 2006 Aug;63(8):1189-93 [PMID: 16908751]
  13. Expert Rev Mol Med. 2019 Dec 10;21:e8 [PMID: 31818346]
  14. Nature. 1971 Jan 22;229(5282):282 [PMID: 4927206]
  15. Lancet Neurol. 2020 Mar;19(3):202-203 [PMID: 31767342]
  16. Ann Clin Transl Neurol. 2024 Jan;11(1):156-168 [PMID: 38087917]
  17. Nat Rev Neurol. 2020 Feb;16(2):69-83 [PMID: 31959938]
  18. Neurology. 1990 May;40(5):733-40 [PMID: 2184380]
  19. J Neuropathol Exp Neurol. 2022 Sep 19;81(10):796-806 [PMID: 35950950]
  20. Cerebellum. 2020 Dec;19(6):879-896 [PMID: 32666285]
  21. Cerebellum. 2014 Aug;13(4):462-70 [PMID: 24756341]
  22. Neurology. 2005 May 24;64(10):1721-5 [PMID: 15911798]
  23. Mov Disord. 1999 May;14(3):462-7 [PMID: 10348470]
  24. Neurol Clin Pract. 2022 Apr;12(2):183-186 [PMID: 35747894]
  25. Acta Neuropathol. 2023 Mar;145(3):265-283 [PMID: 36607423]
  26. Tremor Other Hyperkinet Mov (N Y). 2017 Jul 13;7:473 [PMID: 28966877]
  27. Front Hum Neurosci. 2023 Oct 31;17:1271046 [PMID: 38021224]
  28. Eur Rev Med Pharmacol Sci. 2022 Apr;26(8):2721-2726 [PMID: 35503617]
  29. Mov Disord. 2001 Sep;16(5):914-20 [PMID: 11746622]
  30. Front Neurol. 2021 Nov 29;12:790027 [PMID: 34912292]
  31. Ann Clin Transl Neurol. 2024 Jun;11(6):1514-1525 [PMID: 38644741]
  32. Cerebellum. 2021 Apr;20(2):266-281 [PMID: 33048308]
  33. Mov Disord. 2002 Mar;17(2):313-6 [PMID: 11921117]
  34. Aging Dis. 2023 Aug 1;14(4):1360-1373 [PMID: 37163423]
  35. Eur J Neurol. 2013 Apr;20(4):725-7 [PMID: 22925197]
  36. Cerebellum. 2024 May 15;: [PMID: 38748348]
  37. J Neuropathol Exp Neurol. 2023 Apr 20;82(5):454-455 [PMID: 36943259]
  38. Tremor Other Hyperkinet Mov (N Y). 2020 Jun 11;10:4 [PMID: 32775018]
  39. Parkinsonism Relat Disord. 2024 May;122:106086 [PMID: 38538475]
  40. Neurology. 1995 Apr;45(4):645-8 [PMID: 7723949]
  41. Tremor Other Hyperkinet Mov (N Y). 2020 Aug 13;10:27 [PMID: 32864186]
  42. Neurology. 2007 Nov 20;69(21):1982-9 [PMID: 18025392]
  43. Am J Med Genet A. 2022 Apr;188(4):1251-1258 [PMID: 34913263]
  44. Biomolecules. 2021 Dec 02;11(12): [PMID: 34944457]
  45. Front Neurol. 2024 Mar 26;15:1345873 [PMID: 38595847]
  46. Front Neurol. 2018 Dec 07;9:1077 [PMID: 30581416]
  47. J Neurol Neurosurg Psychiatry. 1984 May;47(5):466-70 [PMID: 6736976]
  48. Brain. 2012 Jan;135(Pt 1):105-16 [PMID: 22120148]
  49. Neuroepidemiology. 2022;56(5):373-379 [PMID: 35940165]
  50. Neurol Clin Pract. 2023 Jun;13(3):e200162 [PMID: 37256209]
  51. Neurology. 2006 Jun 13;66(11):1756-9 [PMID: 16769958]
  52. Neurol Sci. 2023 Jun;44(6):2003-2015 [PMID: 36689009]
  53. Parkinsonism Relat Disord. 2021 Oct;91:42-47 [PMID: 34482193]
  54. Exp Ther Med. 2022 Feb;23(2):167 [PMID: 35069848]
  55. Lancet Neurol. 2020 Mar;19(3):266-270 [PMID: 31767343]
  56. Neurol India. 2018 Mar-Apr;66(Supplement):S36-S47 [PMID: 29503326]
  57. Mov Disord. 2016 Mar;31(3):393-401 [PMID: 26861543]
  58. Neurology. 2020 Jan 14;94(2):55-56 [PMID: 31882524]
  59. Brain Connect. 2024 Aug;14(6):340-350 [PMID: 38874981]
  60. Front Neurol. 2021 Mar 26;12:650601 [PMID: 33841316]
  61. Neuroepidemiology. 2014;42(2):81-9 [PMID: 24335621]
  62. Neuroepidemiology. 2020;54(2):180-184 [PMID: 32023613]
  63. J Neural Transm (Vienna). 2024 Jul 24;: [PMID: 39043978]
  64. Acta Neurol Scand. 2019 Jun;139(6):491-496 [PMID: 30977113]
  65. Cerebellum. 2023 Apr 6;: [PMID: 37022657]
  66. MMW Fortschr Med. 2007 May 21;149 Suppl 2:94-6 [PMID: 17724978]
  67. Int Rev Neurobiol. 2022;163:65-101 [PMID: 35750370]
  68. Practitioner. 2012 Feb;256(1748):21-4, 3 [PMID: 22497105]
  69. Neurology. 1988 Jul;38(7):1141-2 [PMID: 3386834]
  70. J Neurol Neurosurg Psychiatry. 2011 Jul;82(7):761-5 [PMID: 21436230]
  71. Mov Disord Clin Pract. 2024 Feb;11(2):136-142 [PMID: 38386479]
  72. J Neurol Sci. 2016 Aug 15;367:122-7 [PMID: 27423573]
  73. JAMA. 2024 Aug 6;332(5):418-419 [PMID: 38976274]
  74. Neuroscience. 2021 May 10;462:262-273 [PMID: 33212218]
  75. Mov Disord. 2014 Sep;29(10):1329-30 [PMID: 25042039]
  76. Tremor Other Hyperkinet Mov (N Y). 2020 Aug 13;10:28 [PMID: 32864187]
  77. Arch Neurol. 2005 Jun;62(6):1004-7 [PMID: 15956174]
  78. Mov Disord. 2014 Nov;29(13):1637-47 [PMID: 24531928]

MeSH Term

Humans
Essential Tremor
Prognosis

Word Cloud

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