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Frontiers in cell and developmental biology
2024;12 1464815.

Mechanisms of the NAD salvage pathway in enhancing skeletal muscle function.

Mengzhu Su, Fanghui Qiu, Yansong Li, Tongtong Che, Ningning Li, Shuangshuang Zhang
Author Information
  1. Mengzhu Su: Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, China.
  2. Fanghui Qiu: School of Physical Education, Qingdao University, Qingdao, China.
  3. Yansong Li: School of Physical Education, Qingdao University, Qingdao, China.
  4. Tongtong Che: School of Physical Education, Qingdao University, Qingdao, China.
  5. Ningning Li: School of Physical Education, Qingdao University, Qingdao, China.
  6. Shuangshuang Zhang: Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, China.
PMID: 39372950 DOI: 10.3389/fcell.2024.1464815

Abstract

Nicotinamide adenine dinucleotide (NAD) is crucial for cellular energy production, serving as a coenzyme in oxidation-reduction reactions. It also supports enzymes involved in processes such as DNA repair, aging, and immune responses. Lower NAD levels have been associated with various diseases, highlighting the importance of replenishing NAD+. Nicotinamide phosphoribosyltransferase (NAMPT) plays a critical role in the NAD salvage pathway, which helps sustain NAD levels, particularly in high-energy tissues like skeletal muscle.This review explores how the NAMPT-driven NAD salvage pathway influences skeletal muscle health and functionality in aging, type 2 diabetes mellitus (T2DM), and skeletal muscle injury. The review offers insights into enhancing the salvage pathway through exercise and NAD boosters as strategies to improve muscle performance. The findings suggest significant potential for using this pathway in the diagnosis, monitoring, and treatment of skeletal muscle conditions.

Keywords

NAD+ NAMPT T2DM aging skelelal muscle

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