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International journal of molecular sciences
Oct 05, 2024;25 (19):

Pentadecanoic Acid-Releasing PDMS: Towards a New Material to Prevent Biofilm Formation.

Caterina D'Angelo, Serena Faggiano, Paola Imbimbo, Elisabetta Viale, Angela Casillo, Stefano Bettati, Diana Olimpo, Maria Luisa Tutino, Daria Maria Monti, Maria Michela Corsaro, Luca Ronda, Ermenegilda Parrilli
Author Information
  1. Caterina D'Angelo: Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy. ORCID
  2. Serena Faggiano: Department of Food and Drug, University of Parma, Parco Area delle Scienze 23/A, 43124 Parma, Italy. ORCID
  3. Paola Imbimbo: Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy. ORCID
  4. Elisabetta Viale: Department of Medicine and Surgery, University of Parma, Via Volturno 39, 43125 Parma, Italy.
  5. Angela Casillo: Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy. ORCID
  6. Stefano Bettati: Institute of Biophysics, National Research Council (CNR), Via G. Moruzzi 1, 56124 Pisa, Italy. ORCID
  7. Diana Olimpo: Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy. ORCID
  8. Maria Luisa Tutino: Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy. ORCID
  9. Daria Maria Monti: Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy. ORCID
  10. Maria Michela Corsaro: Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy. ORCID
  11. Luca Ronda: Institute of Biophysics, National Research Council (CNR), Via G. Moruzzi 1, 56124 Pisa, Italy. ORCID
  12. Ermenegilda Parrilli: Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy. ORCID
PMID: 39409056 DOI: 10.3390/ijms251910727

Abstract

Microbial biofilm formation on medical devices paves the way for device-associated infections. is one of the most common strains involved in such infections as it is able to colonize numerous devices, such as intravenous catheters, prosthetic joints, and heart valves. We previously reported the antibiofilm activity against of pentadecanoic acid (PDA) deposited by drop-casting on the silicon-based polymer poly(dimethyl)siloxane (PDMS). This material exerted an antibiofilm activity by releasing PDA; however, a toxic effect on bacterial cells was observed, which could potentially favor the emergence of resistant strains. To develop a PDA-functionalized material for medical use and overcome the problem of toxicity, we produced PDA-doped PDMS by either spray-coating or PDA incorporation during PDMS polymerization. Furthermore, we created a strategy to assess the kinetics of PDA release using ADIFAB, a very sensitive free fatty acids fluorescent probe. Spray-coating resulted in the most promising strategy as the concentration of released PDA was in the range 0.8-1.5 μM over 21 days, ensuring long-term effectiveness of the antibiofilm molecule. Moreover, the new coated material resulted biocompatible when tested on immortalized human keratinocytes. Our results indicate that PDA spray-coated PDMS is a promising material for the production of medical devices endowed with antibiofilm activity.

Keywords

ABIFAB PDMS S. epidermidis antibiofilm pentadecanoic acid surface coating

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MeSH Term

Biofilms
Staphylococcus epidermidis
Humans
Dimethylpolysiloxanes
Fatty Acids
Anti-Bacterial Agents
Keratinocytes

Chemicals

Dimethylpolysiloxanes
Fatty Acids
baysilon
pentadecanoic acid
Anti-Bacterial Agents
Journal Article

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