Clarifying the relationship between economic development and human well-being is conducive to promoting high-quality economic development. This study focused on 16 prefecture-level cities in the Qinghai-Xizang Plateau region. The critic weighting method assessed the 2007-2018 human well-being index (HWI). The Tapio decoupling model allowed the study of the human well-being decoupling state. Finally, the drivers of decoupling between economic development and human well-being were analyzed using the Logarithmic Mean Divisia Index method. The results indicated that (1) almost all cities in the study region had an upward 2007-2018 HWI trend, but there were significant differences in growth magnitude and change trend. (2) Economic development and human well-being in the study region in 2007-2018 had expansion negative decoupling, thus, human well-being increased with economic growth, but not as fast as gross domestic product. 9 cities in 2007 showed weak decoupling, expansion connection, and expansion negative decoupling, increasing to 13 cities by 2018, indicating that human well-being development gradually improved from 2007 to 2018. (3) For most cities, the economic scale effect was the most influential factor in the decoupling of economic development and human well-being. Therefore, this study provided policy recommendations for decoupling economic development and human well-being.
