Background: This study aimed to examine the quality of life and the factors that determine the quality of life of infertile couples. Methods: The research was conducted as a cross-sectional study at the Gynecology and Obstetrics Clinic "Narodni Front" in Belgrade, the Special Gynecology Hospital "Ferona" in Novi Sad, the Special Hospital for the Treatment of Sterility and In Vitro Fertilization "Spebo Medikal" in Leskovac and the General Hospital in Valjevo, Serbia in 2022, on a sample of 378 infertile couples. The data were collected by means of a questionnaire, the integral part of which is the standardized FertiQoL scale. Independent -test and one-way ANOVA were used to determine differences. A value of <0.05 was considered statistically significant. Results: Women achieve a significantly lower score on the quality of life questionnaire (69.34��11.05) compared to men (73.96��9.87). Women exhibit significantly lower scores in the area of physical, emotional and social functioning (<0.05). Men who live in the countryside show a lower quality of life score in the emotional (=0.029) and social (=0.042) domains. In addition, men over 40 years of age and with a high level of education have a lower quality of life (=0.08). Conclusion: Women have a lower quality of life, as do men from rural areas and over 40 years of age. A multi-disciplinary approach and community education, as well as the provision of social support with a special emphasis on emotional and material support, would significantly contribute to improving the quality of life of infertile couples.
