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Oct 18, 2024;16 (20):

Renal Health Through Medicine-Food Homology: A Comprehensive Review of Botanical Micronutrients and Their Mechanisms.

Yi Zhao, Jian-Ye Song, Ru Feng, Jia-Chun Hu, Hui Xu, Meng-Liang Ye, Jian-Dong Jiang, Li-Meng Chen, Yan Wang
Author Information
  1. Yi Zhao: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. ORCID
  2. Jian-Ye Song: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  3. Ru Feng: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  4. Jia-Chun Hu: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  5. Hui Xu: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  6. Meng-Liang Ye: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  7. Jian-Dong Jiang: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  8. Li-Meng Chen: Department of Nephrology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China. ORCID
  9. Yan Wang: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. ORCID
PMID: 39458524 DOI: 10.3390/nu16203530

Abstract

BACKGROUND: As an ancient concept and practice, "food as medicine" or "medicine-food homology" is receiving more and more attention these days. It is a tradition in many regions to intake medicinal herbal food for potential health benefits to various organs and systems including the kidney. Kidney diseases usually lack targeted therapy and face irreversible loss of function, leading to dialysis dependence. As the most important organ for endogenous metabolite and exogenous nutrient excretion, the status of the kidney could be closely related to daily diet. Therefore, medicinal herbal food rich in antioxidative, anti-inflammation micronutrients are ideal supplements for kidney protection. Recent studies have also discovered its impact on the "gut-kidney" axis.
METHODS: Here, we review and highlight the kidney-protective effects of botanicals with medicine-food homology including the most frequently used and (Oliv.) Diels, concerning their micronutrients and mechanism, offering a basis and perspective for utilizing and exploring the key substances in medicinal herbal food to protect the kidney.
RESULTS: The index for medicine-food homology in China contains mostly botanicals while many of them are also consumed by people in other regions. Micronutrients including flavonoids, polysaccharides and others present powerful activities towards renal diseases.
CONCLUSIONS: Botanicals with medicine-food homology are widely speeded over multiple regions and incorporating these natural compounds into dietary habits or as supplements shows promising future for renal health.

Keywords

botanicals gut���kidney axis kidney protection medicine���food homology

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Grants

  1. 82173888/National Natural Science Foundation of China
  2. 81973290/National Natural Science Foundation of China
  3. 2021-I2M-1-007/Medical and Health Technology Innovation Project of Chinese Academy of Medical Sciences
  4. 2022-I2M-2-002/Medical and Health Technology Innovation Project of Chinese Academy of Medical Sciences
  5. 2021-I2M-1-028/Medical and Health Technology Innovation Project of Chinese Academy of Medical Sciences
  6. Z141102004414062/Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study

MeSH Term

Humans
Micronutrients
Kidney
Kidney Diseases
Plants, Medicinal
Dietary Supplements

Chemicals

Micronutrients
Journal Article Review

Word Cloud

Created with Highcharts 10.0.0kidneyhomologyregionsmedicinalherbalfoodincludingbotanicalsmedicine-foodmanyhealthdiseasesmicronutrientssupplementsprotectionalsoaxisMicronutrientsrenalBACKGROUND:ancientconceptpractice"foodmedicine""medicine-foodhomology"receivingattentiondaystraditionintakepotentialbenefitsvariousorganssystemsKidneyusuallylacktargetedtherapyfaceirreversiblelossfunctionleadingdialysisdependenceimportantorganendogenousmetaboliteexogenousnutrientexcretionstatuscloselyrelateddailydietThereforerichantioxidativeanti-inflammationidealRecentstudiesdiscoveredimpact"gut-kidney"METHODS:reviewhighlightkidney-protectiveeffectsfrequentlyusedOlivDielsconcerningmechanismofferingbasisperspectiveutilizingexploringkeysubstancesprotectRESULTS:indexChinacontainsmostlyconsumedpeopleflavonoidspolysaccharidesotherspresentpowerfulactivitiestowardsCONCLUSIONS:BotanicalswidelyspeededmultipleincorporatingnaturalcompoundsdietaryhabitsshowspromisingfutureRenalHealthMedicine-FoodHomology:ComprehensiveReviewBotanicalMechanismsgut���kidneymedicine���food

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