Baby Open Brains: An Open-Source Repository of Infant Brain Segmentations.
Eric Feczko, Sally M Stoyell, Lucille A Moore, Dimitrios Alexopoulos, Maria Bagonis, Kenneth Barrett, Brad Bower, Addison Cavender, Taylor A Chamberlain, Greg Conan, Trevor Km Day, Dhruman Goradia, Alice Graham, Lucas Heisler-Roman, Timothy J Hendrickson, Audrey Houghton, Omid Kardan, Elizabeth A Kiffmeyer, Erik G Lee, Jacob T Lundquist, Carina Lucena, Tabitha Martin, Anurima Mummaneni, Mollie Myricks, Pranav Narnur, Anders J Perrone, Paul Reiners, Amanda R Rueter, Hteemoo Saw, Martin Styner, Sooyeon Sung, Barry Tiklasky, Jessica L Wisnowski, Essa Yacoub, Brett Zimmermann, Christopher D Smyser, Monica D Rosenberg, Damien A Fair, Jed T Elison
Author Information
Eric Feczko: Masonic Institute for the Developing Brain, University of Minnesota. ORCID
Sally M Stoyell: Masonic Institute for the Developing Brain, University of Minnesota. ORCID
Lucille A Moore: Masonic Institute for the Developing Brain, University of Minnesota.
Dimitrios Alexopoulos: Washington University.
Maria Bagonis: PrimeNeuro.
Kenneth Barrett: PrimeNeuro.
Brad Bower: PrimeNeuro.
Addison Cavender: Institute of Child Development, University of Minnesota.
Taylor A Chamberlain: University of Chicago. ORCID
Greg Conan: Masonic Institute for the Developing Brain, University of Minnesota.
Trevor Km Day: Masonic Institute for the Developing Brain, University of Minnesota.
Dhruman Goradia: PrimeNeuro.
Alice Graham: Oregon Health Science University.
Lucas Heisler-Roman: PrimeNeuro.
Timothy J Hendrickson: Masonic Institute for the Developing Brain, University of Minnesota.
Audrey Houghton: Masonic Institute for the Developing Brain, University of Minnesota.
Omid Kardan: University of Michigan.
Elizabeth A Kiffmeyer: Department of Neuroscience, University of Minnesota.
Erik G Lee: Masonic Institute for the Developing Brain, University of Minnesota.
Jacob T Lundquist: Masonic Institute for the Developing Brain, University of Minnesota.
Carina Lucena: PrimeNeuro.
Tabitha Martin: Institute of Child Development, University of Minnesota.
Anurima Mummaneni: University of Chicago.
Mollie Myricks: PrimeNeuro.
Pranav Narnur: PrimeNeuro.
Anders J Perrone: Masonic Institute for the Developing Brain, University of Minnesota.
Paul Reiners: Masonic Institute for the Developing Brain, University of Minnesota.
Amanda R Rueter: Masonic Institute for the Developing Brain, University of Minnesota.
Hteemoo Saw: Institute of Child Development, University of Minnesota.
Martin Styner: University of North Carolina.
Sooyeon Sung: Masonic Institute for the Developing Brain, University of Minnesota.
Barry Tiklasky: Masonic Institute for the Developing Brain, University of Minnesota.
Jessica L Wisnowski: Department of Radiology, University of Southern California.
Essa Yacoub: Center for Magnetic Resonance Research, University of Minnesota.
Brett Zimmermann: Institute of Child Development, University of Minnesota.
Reproducibility of neuroimaging research on infant brain development remains limited due to highly variable protocols and processing approaches. Progress towards reproducible pipelines is limited by a lack of benchmarks such as gold standard brain segmentations. Addressing this core limitation, we constructed the Baby Open Brains (BOBs) Repository, an open source resource comprising manually curated and expert-reviewed infant brain segmentations. Markers and expert reviewers manually segmented anatomical MRI data from 71 infant imaging visits across 51 participants, using both T1w and T2w images per visit. Anatomical images showed dramatic differences in myelination and intensities across the 1 to 9 month age range, emphasizing the need for densely sampled gold standard manual segmentations in these ages. The BOBs repository is publicly available through the Masonic Institute for the Developing Brain (MIDB) Open Data Initiative, which links S3 storage, Datalad for version control, and BrainBox for visualization. This repository represents an open-source paradigm, where new additions and changes can be added, enabling a community-driven resource that will improve over time and extend into new ages and protocols. These manual segmentations and the ongoing repository provide a benchmark for evaluating and improving pipelines dependent upon segmentations in the youngest populations. As such, this repository provides a vitally needed foundation for early-life large-scale studies such as HBCD.
