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Renal failure
Dec, 2024;46 (2): 2417738.

The role of moderate to vigorous physical activity level and number of treatments/medications in mediating the effect of body mass index on diabetic nephropathy: a Mendelian randomization study.

Shasha Hu, Yuling Chen, Mingjie He, Jun Wen, Aimin Zhong, Dandan Zhan, Zhibin Ye
Author Information
  1. Shasha Hu: Department of Nephrology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
  2. Yuling Chen: Department of Nephrology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
  3. Mingjie He: Department of Nephrology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
  4. Jun Wen: Department of Nephrology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
  5. Aimin Zhong: Department of Nephrology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
  6. Dandan Zhan: Department of Nephrology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
  7. Zhibin Ye: Department of Nephrology, Huadong Hospital affiliated to Fudan University, Shanghai, China.
PMID: 39466707 DOI: 10.1080/0886022X.2024.2417738

Abstract

BACKGROUND: Body mass index (BMI) is associated with diabetic nephropathy (DN). However, the mediator factors in the BMI-DN effects remain unclear.
METHODS: Univariate and multivariate Mendelian randomization (MR) analysis were performed to estimate the association between six lifestyles (moderate to vigorous physical activity levels, years of schooling, BMI, nap during day, number of treatments/medications taken and coffee intake) and DN. MR Egger, Weighted median, Simple mode, and Weighted mode was supplemental methods to Inverse variance weighted. Sensitivity analysis included heterogeneity test, horizontal pleiotropy test, and Leave-One-Out. Additionally, mediation MR was conducted to evaluate the mediating role of lifestyles between BMI and DN. Finally, functional enrichment analysis based on the mediation MR results was performed.
RESULTS: univariate and multivariate Mendelian randomization (MR) analysis were performed to estimate the association between six lifestyles (moderate to vigorous physical activity levels, years of schooling, BMI, nap during day, number of treatments/medications taken and coffee intake) and DN. MR Egger, Weighted median, Simple mode, and Weighted mode was supplemental methods to Inverse variance weighted. Sensitivity analysis included heterogeneity test, horizontal pleiotropy test, and Leave-One-Out. Additionally, mediation MR was conducted to evaluate the mediating role of lifestyles between BMI and DN. Finally, functional enrichment analysis based on the mediation MR results was performed.
CONCLUSION: our results supported mediation role of vigorous physical activity level and number of treatments/medications in BMI-DN effects.

Keywords

Body mass index Mendelian randomization diabetic nephropathy mediation effect type 2 diabetes

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MeSH Term

Humans
Mendelian Randomization Analysis
Body Mass Index
Diabetic Nephropathies
Exercise
Risk Factors
Life Style
Journal Article

Word Cloud

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