Sudeshna Nandi: Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany University of Calcutta Kolkata India.
Rimpa Sikder: Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany University of Calcutta Kolkata India.
Anish Nag: Department of Life Sciences CHRIST (Deemed to be University) Bangalore Karnataka India.
Somanjana Khatua: Department of Botany, Faculty of Science University of Allahabad Prayagraj Uttar Pradesh India.
Surjit Sen: Department of Botany Fakir Chand College Kolkata India.
Nilanjan Chakraborty: Department of Botany Scottish Church College Kolkata India.
Arghya Naskar: Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany University of Calcutta Kolkata India.
Kairat Zhakipbekov: Department of Organization and Management and Economics of Pharmacy and Clinical Pharmacy Asfendiyarov Kazakh National Medical University Almaty Kazakhstan.
Krishnendu Acharya: Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany University of Calcutta Kolkata India.
Solomon Habtemariam: Pharmacognosy Research & Herbal Analysis Services UK Kent UK.
Dilek Arslan Ateşşahin: Department of Plant and Animal Production, Baskil Vocational School Fırat University Elazıg Turkey.
Tamar Goloshvili: Department of Plant Physiology and Genetic Resources Institute of Botany, Ilia State University Tbilisi Georgia.
Afaf Ahmed Aldahish: Department of Pharmacology, College of Pharmacy King Khalid University Abha Kingdom of Saudi Arabia.
Javad Sharifi-Rad: Department of Biomedical Sciences College of Medicine, Korea University Seoul Republic of Korea. ORCID
Daniela Calina: Department of Clinical Pharmacy University of Medicine and Pharmacy of Craiova Craiova Romania.
cancer remains a critical global health challenge, with limited progress in reducing mortality despite advancements in diagnosis and treatment. The growing resistance of tumors to existing chemotherapy exacerbates this burden. In response, the search for new anticancer compounds from plants has intensified, given their historical success in yielding effective treatments. This review focuses on α-solanine, a glycoalkaloid primarily derived from potato tubers and nightshade family plants, recognized for its diverse biological activities, including anti-allergic, antipyretic, anti-inflammatory, anti-diabetic, and antibiotic properties. Recently, α-solanine has gained attention as a potential anticancer agent. Utilizing resources like PubMed/MedLine, ScienceDirect, Web of Science, Scopus, the American Chemical Society, Google Scholar, Springer Link, Wiley, and various commercial websites, this review consolidates two decades of research on α-solanine's anticancer effects and mechanisms against nine different cancers, highlighting its role in modulating various signaling pathways. It also discusses α-solanine's potential as a lead compound in cancer therapy. The abundant availability of potato peel, often discarded as waste or sold cheaply, is suggested as a sustainable source for large-scale α-solanine extraction. The study concludes that α-solanine holds promise as a standalone or adjunctive cancer treatment. However, further research is necessary to optimize this lead compound and mitigate its toxicity through various strategies.
