Yunke Yu: College of Life Science, Shandong Agricultural University, Taian 271018, China.
Chao Wu: College of Life Science, Shandong Agricultural University, Taian 271018, China.
Le Jia: College of Life Science, Shandong Agricultural University, Taian 271018, China; Shandong Ocean Agricultural Development Co. LTD, Jining 272600, China. Electronic address: jiale0525@163.com.
Jianjun Zhang: College of Life Science, Shandong Agricultural University, Taian 271018, China; Shandong Ocean Agricultural Development Co. LTD, Jining 272600, China. Electronic address: yyxf0315@163.com.
The study was aimed to develop natural non-toxic substances to prevent LPS-induced liver damages and its complications. In present work, a pyranose polysaccharide of Oudemansiella radicata polysaccharides (ORP) with typical characteristics of ��-type glycosidic linkage was isolated from the O. radicata fruiting body by physico-chemical analysis, and the potential impact against LPS-induced liver damage were performed in mice model. The results demonstrated that ORP showed significant hepatoprotective effects through its potential anti-oxidative, anti-inflammatory and anti-apoptosis activities via regulating the TLR4/NF-��B and Bax/Bcl-2 signaling pathway, independently or synergistically. These findings had established a robust theoretical framework for promoting the comprehensive utilization of ORP as supplements in the development of functional foods or drugs targeting LPS-induced liver damage and its associated complications.
