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Current opinion in virology
2024 Sep-Dec;68-69 101437.

Blood virome research in myalgic encephalomyelitis/chronic fatigue syndrome: challenges and opportunities.

Dominic Obraitis, Dawei Li
Author Information
  1. Dominic Obraitis: Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Neuroscience and Behavior Program, Florida Atlantic University, Boca Raton, FL 33431, USA.
  2. Dawei Li: Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: dawei.li@ttuhsc.edu.
PMID: 39537445 DOI: 10.1016/j.coviro.2024.101437

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease with a complex clinical presentation and an unknown etiology. Various viral infections have been proposed as potential triggers of ME/CFS onset, but no specific pathogen has been identified in all cases of postinfectious ME/CFS. The symptomatology of the postacute sequelae of SARS-CoV-2, or long COVID, mirrors that of ME/CFS, with nearly half of long COVID patients meeting ME/CFS diagnostic criteria. The influx of newly diagnosed patients has reinvigorated interest in ME/CFS pathogenesis research, with an emphasis on viral triggers. This review summarizes the current understanding of ME/CFS research on viral triggers, including blood virome screening studies. To further elucidate the molecular basis of ME/CFS, there is a need to develop innovative bioinformatics tools capable of analyzing complex virome data and integrating multiomics information.

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Grants

  1. R03 AI147084/NIAID NIH HHS
  2. R21 AI159710/NIAID NIH HHS
  3. U54 AI178855/NIAID NIH HHS

MeSH Term

Fatigue Syndrome, Chronic
Humans
Virome
COVID-19
SARS-CoV-2
Journal Article Review
Article has an altmetric score of 8

Word Cloud

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