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Methods in molecular biology (Clifton, N.J.)
2025;2877 317-327.

Marburg Virus Aerosol Infection in Animal Models.

Trenton Bushmaker
Author Information
  1. Trenton Bushmaker: Laboratory of Virology, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. bushmakertj@niaid.nih.gov.
PMID: 39585630 DOI: 10.1007/978-1-0716-4256-6_21

Abstract

Aerosol challenge provides the ability to investigate in-depth mucosal virus exposure, including modeling of airborne transmission from high-consequence viral infection. For filoviruses, in particular Marburg and Ebola viruses, aerosol infection is considered in connection to their potential misuse. Aerosol exposure with filoviruses has been used to study disease progression, pathogenicity, and the efficacy of medical countermeasures. The aim of this protocol is to provide a general outline for aerosol exposure of animals with filoviruses, specifically Marburg virus.

Keywords

Aerosol exposure Filovirus MARV NHP model Rodent models

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MeSH Term

Animals
Marburgvirus
Aerosols
Marburg Virus Disease
Disease Models, Animal
Mice
Humans

Chemicals

Aerosols
Journal Article
Article has an altmetric score of 1

Word Cloud

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