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Frontiers in physiology
2024;15 1491815.

Molecular mechanisms of lipid droplets-mitochondria coupling in obesity and metabolic syndrome: insights and pharmacological implications.

Chunmei Zhang, Mingxuan Zheng, Runlin Bai, Jiale Chen, Hong Yang, Gan Luo
Author Information
  1. Chunmei Zhang: School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  2. Mingxuan Zheng: School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  3. Runlin Bai: School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  4. Jiale Chen: School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  5. Hong Yang: School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  6. Gan Luo: Department of Orthopedics, Chengdu Integrated Traditional Chinese Medicine & Western Medicine Hospital/Chengdu First People's Hospital, Chengdu, China.
PMID: 39588271 DOI: 10.3389/fphys.2024.1491815

Abstract

Abnormal lipid accumulation is a fundamental contributor to obesity and metabolic disorders. Lipid droplets (LDs) and mitochondria (MT) serve as organelle chaperones in lipid metabolism and energy balance. LDs play a crucial role in lipid storage and mobilization, working in conjunction with MT to regulate lipid metabolism within the liver, brown adipose tissue, and skeletal muscle, thereby maintaining metabolic homeostasis. The novelty of our review is the comprehensive description of LD and MT interaction mechanisms. We also focus on the current drugs that target this metabolism, which provide novel approaches for obesity and related metabolism disorder treatment.

Keywords

lipid droplets metabolic syndrome mitochondria obesity peridroplet mitochondria pharmacotherapy

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