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Nov 13, 2024;11 (11):

Lumpy Skin Disease: Insights into Molecular Pathogenesis and Control Strategies.

Ali Haider, Zaheer Abbas, Ahsen Taqveem, Abid Ali, Mohsin Khurshid, Rania F El Naggar, Mohammed A Rohaim, Muhammad Munir
Author Information
  1. Ali Haider: Department of Allied Health Sciences, The University of Lahore, Gujrat Campus, Gujrat 50700, Pakistan. ORCID
  2. Zaheer Abbas: Department of Allied Health Sciences, The University of Lahore, Gujrat Campus, Gujrat 50700, Pakistan.
  3. Ahsen Taqveem: Institute of Microbiology, Government College University Faisalabad, Faisalabad 38000, Pakistan.
  4. Abid Ali: Department of Allied Health Sciences, The University of Chenab, Gujrat 50700, Pakistan.
  5. Mohsin Khurshid: Institute of Microbiology, Government College University Faisalabad, Faisalabad 38000, Pakistan. ORCID
  6. Rania F El Naggar: Department of Virology, Faculty of Veterinary Medicine, University of Sadat City, Sadat 32897, Egypt.
  7. Mohammed A Rohaim: Department of Virology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt. ORCID
  8. Muhammad Munir: Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, UK. ORCID
PMID: 39591335 DOI: 10.3390/vetsci11110561

Abstract

Lumpy skin disease (LSD) is a viral infection that affects buffaloes and cattle across various regions, including both tropical and temperate climates. Intriguingly, the virus-carrying skin sores remain the primary source of infection for extended periods, exacerbated by the abundance of vectors in disease-endemic countries. Recent scientific advances have revealed the molecular aspects of LSD and offered improved vaccines and valuable antiviral targets. This review summarizes the molecular features of LSD and its effect on various livestock species. We then provide an extensive discussion on the transmission dynamics of LSD and the roles of vectors in its continued spread among livestock populations. Additionally, this review critically analyses the rationales behind, as well as the affordability and effectiveness, of current control strategies worldwide.

Keywords

disease control livestock lumpy skin disease virus pathogenesis transmission vectors

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