EDDINet: Enhancing drug-drug interaction prediction via information flow and consensus constrained multi-graph contrastive learning.
Hong Wang, Luhe Zhuang, Yijie Ding, Prayag Tiwari, Cheng Liang
Author Information
Hong Wang: School of Information Science and Engineering, Shandong Normal University, Jinan, 250358, China. Electronic address: wanghong106@163.com.
Luhe Zhuang: School of Information Science and Engineering, Shandong Normal University, Jinan, 250358, China. Electronic address: luhezhuang@163.com.
Yijie Ding: Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, Quzhou 324003, China. Electronic address: wuxi_dyj@csj.uestc.edu.cn.
Prayag Tiwari: School of Information Technology, Halmstad University, Halmstad 301 18, Sweden. Electronic address: prayag.tiwari@hh.se.
Cheng Liang: School of Information Science and Engineering, Shandong Normal University, Jinan, 250358, China. Electronic address: ALCS417@sdnu.edu.cn.
Predicting drug-drug interactions (DDIs) is crucial for understanding and preventing adverse drug reactions (ADRs). However, most existing methods inadequately explore the interactive information between drugs in a self-supervised manner, limiting our comprehension of drug-drug associations. This paper introduces EDDINet: Enhancing Drug-Drug Interaction Prediction via Information Flow and Consensus-Constrained Multi-Graph Contrastive Learning for precise DDI prediction. We first present a cross-modal information-flow mechanism to integrate diverse drug features, enriching the structural insights conveyed by the drug feature vector. Next, we employ contrastive learning to filter various biological networks, enhancing the model's robustness. Additionally, we propose a consensus regularization framework that collaboratively trains multi-view models, producing high-quality drug representations. To unify drug representations derived from different biological information, we utilize an attention mechanism for DDI prediction. Extensive experiments demonstrate that EDDINet surpasses state-of-the-art unsupervised models and outperforms some supervised baseline models in DDI prediction tasks. Our approach shows significant advantages and holds promising potential for advancing DDI research and improving drug safety assessments. Our codes are available at: https://github.com/95LY/EDDINet_code.
