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Virulence
Dec, 2024;15 (1): 2436060.

Pathogenicity and virulence of : What do we really know?

Zahra Omole, Nick Dorrell, Abdi Elmi, Fauzy Nasher, Ozan Gundogdu, Brendan W Wren
Author Information
  1. Zahra Omole: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
  2. Nick Dorrell: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
  3. Abdi Elmi: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
  4. Fauzy Nasher: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
  5. Ozan Gundogdu: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK. ORCID
  6. Brendan W Wren: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK. ORCID
PMID: 39648291 DOI: 10.1080/21505594.2024.2436060

Abstract

is the leading cause of bacterial gastroenteritis and is a major public health concern worldwide. Despite its importance, our understanding of how causes diarrhoea and interacts with its hosts is limited due to the absence of appropriate infection models and established virulence factors found in other enteric pathogens. Additionally, despite its genetic diversity, non-pathogenic strains are unknown. Regardless of these limitations, significant progress has been made in understanding how uses a complex array of factors which aid the bacterium to survive and respond to host defences. This review provides an update on fitness and virulence determinants of this important pathogen and questions our knowledge on these determinants that are often based on inferred genomics knowledge and surrogate infection models.

Keywords

Campylobacter jejuni bacterial gastroenteritis fitness factors surrogate infection models virulence

References

  1. Trends Microbiol. 2016 Jan;24(1):51-62 [PMID: 26549582]
  2. FEMS Microbiol Lett. 2007 Oct;275(2):278-85 [PMID: 17714477]
  3. Infect Immun. 1989 May;57(5):1438-44 [PMID: 2707853]
  4. Infect Immun. 1993 Aug;61(8):3440-8 [PMID: 8335374]
  5. Science. 2000 Oct 13;290(5490):354-7 [PMID: 11030657]
  6. Mol Cell. 2013 Sep 12;51(5):584-93 [PMID: 23954347]
  7. Heliyon. 2019 Nov 14;5(11):e02814 [PMID: 31763476]
  8. Clin Microbiol Rev. 1998 Jul;11(3):555-67 [PMID: 9665983]
  9. Vaccine. 2006 May 1;24(18):3762-71 [PMID: 16098634]
  10. Microbiology (Reading). 2015 May;161(Pt 5):933-947 [PMID: 25757600]
  11. J Infect Dis. 1997 Dec;176 Suppl 2:S103-5 [PMID: 9396691]
  12. Cell Commun Signal. 2013 Sep 30;11:72 [PMID: 24079544]
  13. Mol Microbiol. 2008 Jul;69(1):77-93 [PMID: 18433445]
  14. J Proteomics. 2014 Feb 26;98:90-8 [PMID: 24382552]
  15. Cell Microbiol. 2003 Mar;5(3):165-74 [PMID: 12614460]
  16. Curr Microbiol. 2009 Feb;58(2):134-8 [PMID: 18956226]
  17. J Bacteriol. 2008 Apr;190(7):2286-97 [PMID: 18223090]
  18. PLoS Pathog. 2020 Jul 2;16(7):e1008620 [PMID: 32614919]
  19. Nat Microbiol. 2018 Aug;3(8):920-931 [PMID: 30038307]
  20. Nature. 2000 Feb 10;403(6770):665-8 [PMID: 10688204]
  21. PLoS Biol. 2017 May 19;15(5):e2001390 [PMID: 28542173]
  22. J Biol Chem. 2004 Jan 16;279(3):2069-76 [PMID: 14578354]
  23. Front Microbiol. 2015 Jul 29;6:751 [PMID: 26284041]
  24. Biochem J. 2004 Mar 15;378(Pt 3):851-6 [PMID: 14662009]
  25. Biomolecules. 2023 Feb 08;13(2): [PMID: 36830692]
  26. Eur J Microbiol Immunol (Bp). 2012 Mar;2(1):32-40 [PMID: 24611119]
  27. PLoS One. 2014 Aug 28;9(8):e106063 [PMID: 25166748]
  28. BMC Infect Dis. 2019 Mar 7;19(1):237 [PMID: 30845966]
  29. Syst Appl Microbiol. 2000 Jun;23(2):165-73 [PMID: 10930067]
  30. Mol Microbiol. 2001 May;40(3):769-77 [PMID: 11359581]
  31. Sci Rep. 2017 Jan 20;7:40878 [PMID: 28106112]
  32. Gut Pathog. 2011 Sep 22;3:13 [PMID: 21939552]
  33. J Proteome Res. 2007 Dec;6(12):4582-91 [PMID: 17973442]
  34. BMC Microbiol. 2012 Aug 13;12:174 [PMID: 22889088]
  35. Science. 2012 Aug 17;337(6096):815 [PMID: 22767897]
  36. Front Cell Infect Microbiol. 2014 Sep 29;4:137 [PMID: 25325018]
  37. FEMS Immunol Med Microbiol. 2007 Feb;49(1):149-54 [PMID: 17266722]
  38. Microorganisms. 2022 Sep 23;10(10): [PMID: 36296171]
  39. Microorganisms. 2020 Mar 11;8(3): [PMID: 32168837]
  40. Microbiol Spectr. 2024 Mar 5;12(3):e0323223 [PMID: 38319111]
  41. PLoS One. 2012;7(9):e46402 [PMID: 23029510]
  42. FEMS Microbiol Lett. 1997 Dec 15;157(2):233-8 [PMID: 9435102]
  43. J Bacteriol. 2009 Nov;191(22):7086-93 [PMID: 19749047]
  44. FEMS Microbiol Lett. 2014 Jul;356(1):8-19 [PMID: 24888326]
  45. J Biol Chem. 1990 Oct 15;265(29):17798-804 [PMID: 2211662]
  46. Infect Immun. 2009 Jun;77(6):2399-407 [PMID: 19349427]
  47. Microbiology (Reading). 2003 Jan;149(Pt 1):153-65 [PMID: 12576589]
  48. Infect Immun. 2015 Dec;83(12):4884-95 [PMID: 26438798]
  49. PLoS Pathog. 2012;8(3):e1002562 [PMID: 22412372]
  50. PLoS Pathog. 2020 Oct 16;16(10):e1009008 [PMID: 33064782]
  51. Gut Microbes. 2015;6(2):143-8 [PMID: 25831043]
  52. Neurology. 1998 Aug;51(2):371-8 [PMID: 9710005]
  53. Avian Dis. 1999 Jul-Sep;43(3):586-9 [PMID: 10494431]
  54. Antibiotics (Basel). 2023 Dec 28;13(1): [PMID: 38247591]
  55. mBio. 2024 Mar 13;15(3):e0343023 [PMID: 38323832]
  56. Appl Environ Microbiol. 2005 Feb;71(2):987-92 [PMID: 15691957]
  57. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2316540120 [PMID: 38170751]
  58. FEMS Immunol Med Microbiol. 2007 Jun;50(1):27-36 [PMID: 17374131]
  59. Mol Microbiol. 1999 May;32(4):691-701 [PMID: 10361274]
  60. PLoS One. 2012;7(11):e50699 [PMID: 23226358]
  61. Comp Immunol Microbiol Infect Dis. 2019 Oct;66:101345 [PMID: 31476607]
  62. Front Microbiol. 2023 Jan 26;13:1071175 [PMID: 36817113]
  63. Emerg Microbes Infect. 2013 Oct;2(10):e65 [PMID: 26038437]
  64. Infect Immun. 2000 Aug;68(8):4384-90 [PMID: 10899834]
  65. Int J Food Microbiol. 1995 Dec;28(2):245-54 [PMID: 8750670]
  66. Infect Immun. 2000 Dec;68(12):6535-41 [PMID: 11083762]
  67. J Bacteriol. 2008 Aug;190(16):5681-9 [PMID: 18556784]
  68. Transbound Emerg Dis. 2018 May;65 Suppl 1:30-48 [PMID: 29663680]
  69. Microbiol Mol Biol Rev. 2010 Mar;74(1):81-94 [PMID: 20197500]
  70. Nature. 2001 Apr 26;410(6832):1099-103 [PMID: 11323673]
  71. Appl Environ Microbiol. 1998 Oct;64(10):3917-22 [PMID: 9758819]
  72. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8855-8857 [PMID: 30143581]
  73. mBio. 2017 May 9;8(3): [PMID: 28487428]
  74. Lett Appl Microbiol. 2020 Apr;70(4):326-330 [PMID: 31981418]
  75. Front Cell Infect Microbiol. 2023 Jul 13;13:1208825 [PMID: 37520433]
  76. Front Cell Infect Microbiol. 2012 Mar 20;2:31 [PMID: 22919623]
  77. Infect Immun. 1998 Mar;66(3):938-43 [PMID: 9488379]
  78. Gut Pathog. 2019 Apr 12;11:14 [PMID: 31044013]
  79. Cell Microbiol. 2018 Mar;20(3): [PMID: 29205766]
  80. J Proteomics. 2019 Mar 20;195:33-40 [PMID: 30641234]
  81. Clin Microbiol Infect. 2014 Jun;20(6):524-9 [PMID: 24102802]
  82. BMC Microbiol. 2009 Oct 16;9:220 [PMID: 19835618]
  83. Mol Microbiol. 2001 Mar;39(5):1225-36 [PMID: 11251839]
  84. BMC Res Notes. 2019 Mar 28;12(1):180 [PMID: 30922352]
  85. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11715-11726 [PMID: 32398371]
  86. J Biol Chem. 2011 Apr 8;286(14):12361-70 [PMID: 21257763]
  87. Mol Microbiol. 2011 Jun;80(5):1296-312 [PMID: 21435039]
  88. Appl Environ Microbiol. 2011 Jan;77(1):57-66 [PMID: 21075890]
  89. Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):16985-16991 [PMID: 32641510]
  90. Mol Microbiol. 1997 Jun;24(5):953-63 [PMID: 9220003]
  91. J Bacteriol. 2022 Jan 18;204(1):e0042121 [PMID: 34606373]
  92. Emerg Infect Dis. 2014 Jun;20(6):1026-9 [PMID: 24856088]
  93. ACS Infect Dis. 2023 Nov 10;9(11):2325-2339 [PMID: 37802046]
  94. Mol Microbiol. 2009 Aug;73(4):650-62 [PMID: 19627497]
  95. Cell Commun Signal. 2013 Oct 21;11:79 [PMID: 24144181]
  96. Ann N Y Acad Sci. 1998 Jun 19;845:307-21 [PMID: 9668364]
  97. Nat Rev Microbiol. 2018 Sep;16(9):551-565 [PMID: 29892020]
  98. PLoS Pathog. 2009 Apr;5(4):e1000382 [PMID: 19360133]
  99. Virulence. 2011 Jan-Feb;2(1):30-40 [PMID: 21266840]
  100. Med Microbiol Immunol. 2012 May;201(2):137-44 [PMID: 21863342]
  101. Microbiology (Reading). 2023 Jul;169(7): [PMID: 37490402]
  102. BMC Genomics. 2015 Jul 04;16:498 [PMID: 26141822]
  103. Infect Immun. 1993 May;61(5):1764-71 [PMID: 8478066]
  104. FEBS J. 2018 Nov;285(21):4060-4070 [PMID: 30194714]
  105. Infect Immun. 2004 Jul;72(7):3769-76 [PMID: 15213117]
  106. Front Cell Infect Microbiol. 2012 Feb 07;2:5 [PMID: 22919597]
  107. PLoS One. 2012;7(8):e42842 [PMID: 22952616]
  108. Methods Mol Biol. 2017;1512:163-169 [PMID: 27885606]
  109. Microbiology (Reading). 2004 Jun;150(Pt 6):1957-1964 [PMID: 15184581]
  110. FEMS Microbiol Ecol. 2010 Nov;74(2):371-81 [PMID: 20722733]
  111. Gut Pathog. 2019 Feb 13;11:4 [PMID: 30805031]
  112. Infect Immun. 2008 Oct;76(10):4431-8 [PMID: 18644887]
  113. Microbiology (Reading). 2010 Jul;156(Pt 7):1953-1962 [PMID: 20338909]
  114. Infect Immun. 2008 Oct;76(10):4498-508 [PMID: 18644884]
  115. Front Microbiol. 2015 Jul 21;6:724 [PMID: 26257713]
  116. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2348-53 [PMID: 23341592]
  117. Microbiology (Reading). 2022 Feb;168(2): [PMID: 35175913]
  118. Mol Microbiol. 2005 Aug;57(4):1022-35 [PMID: 16091041]
  119. J Clin Invest. 2004 Dec;114(11):1659-65 [PMID: 15578098]
  120. Front Cell Infect Microbiol. 2019 May 29;9:177 [PMID: 31192166]
  121. Mol Microbiol. 2004 Apr;52(2):471-84 [PMID: 15066034]
  122. AIMS Microbiol. 2017 Nov 7;3(4):885-898 [PMID: 31294195]
  123. Int J Food Microbiol. 2018 Nov 2;284:120-127 [PMID: 29887505]
  124. J Infect Dis. 2010 Mar;201(5):776-82 [PMID: 20113177]
  125. Microbiol Spectr. 2022 Dec 21;10(6):e0268122 [PMID: 36314968]
  126. Glycobiology. 2016 Apr;26(4):386-97 [PMID: 26582606]
  127. iScience. 2021 Nov 26;24(12):103507 [PMID: 34934926]
  128. Microbiology (Reading). 2023 Aug;169(8): [PMID: 37610804]
  129. Infect Immun. 2009 May;77(5):1959-67 [PMID: 19273563]
  130. Cell Microbiol. 2012 Feb;14(2):226-38 [PMID: 21999233]
  131. Sci Rep. 2018 Nov 19;8(1):16996 [PMID: 30451931]
  132. Microbiology (Reading). 2002 Mar;148(Pt 3):685-694 [PMID: 11882702]
  133. PLoS Pathog. 2018 May 23;14(3):e1007083 [PMID: 29791507]
  134. Infect Immun. 2001 Apr;69(4):2462-9 [PMID: 11254608]
  135. PLoS One. 2011;6(7):e22300 [PMID: 21811584]
  136. Nat Microbiol. 2018 Apr;3(4):494-502 [PMID: 29588538]
  137. Cell Microbiol. 2016 Apr;18(4):561-72 [PMID: 26451973]
  138. Front Microbiol. 2019 Dec 17;10:2864 [PMID: 31921044]
  139. Front Cell Infect Microbiol. 2020 Dec 08;10:590186 [PMID: 33364202]
  140. Int J Mol Sci. 2014 Feb 19;15(2):2840-57 [PMID: 24557579]
  141. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12146-50 [PMID: 17615243]
  142. Pol J Microbiol. 2019;68(2):255-261 [PMID: 31250596]
  143. J Biol Chem. 2012 Mar 23;287(13):10115-10120 [PMID: 22337879]
  144. Curr Opin Microbiol. 2019 Feb;47:32-37 [PMID: 30476739]
  145. EMBO J. 1991 Aug;10(8):2055-61 [PMID: 2065653]
  146. J Immunol. 2010 Jul 1;185(1):748-55 [PMID: 20525894]
  147. Nat Commun. 2021 Feb 26;12(1):1339 [PMID: 33637714]
  148. Infect Immun. 2002 Dec;70(12):6665-71 [PMID: 12438340]
  149. Trends Microbiol. 2001 Aug;9(8):365-6 [PMID: 11519530]
  150. J Proteome Res. 2014 Nov 7;13(11):5136-50 [PMID: 25093254]
  151. Eur J Microbiol Immunol (Bp). 2015 Mar;5(1):68-80 [PMID: 25883795]
  152. Front Cell Infect Microbiol. 2012 Mar 05;2:25 [PMID: 22919617]
  153. Appl Microbiol Biotechnol. 2023 May;107(9):2725-2754 [PMID: 36941439]
  154. Infect Immun. 2012 Dec;80(12):4089-98 [PMID: 22966047]
  155. PLoS Pathog. 2013;9(5):e1003393 [PMID: 23737749]
  156. Microbes Infect. 2009 Oct;11(12):988-94 [PMID: 19631279]
  157. Infect Immun. 2010 Aug;78(8):3540-53 [PMID: 20515930]
  158. Mol Microbiol. 2005 Jan;55(1):90-103 [PMID: 15612919]
  159. Infect Immun. 1995 Nov;63(11):4295-300 [PMID: 7591061]
  160. Biomolecules. 2023 Jan 09;13(1): [PMID: 36671522]
  161. Infect Ecol Epidemiol. 2015 Sep 18;5:28675 [PMID: 26387556]
  162. Res Vet Sci. 2018 Aug;119:170-175 [PMID: 29957495]
  163. J Exp Med. 1993 Nov 1;178(5):1771-5 [PMID: 8228822]
  164. Microb Genom. 2021 Nov;7(11): [PMID: 34766904]
  165. Gut Pathog. 2012 Apr 25;4(1):3 [PMID: 22534208]
  166. Appl Environ Microbiol. 2005 Jun;71(6):3205-12 [PMID: 15933023]
  167. Cells. 2024 Jan 25;13(3): [PMID: 38334616]
  168. J Infect Dis. 1985 Sep;152(3):592-6 [PMID: 4031557]
  169. Genes Dev. 2005 Nov 15;19(22):2645-55 [PMID: 16291643]
  170. Zoonoses Public Health. 2015 Nov;62(7):497-500 [PMID: 25496466]
  171. Chembiochem. 2007 Apr 16;8(6):625-31 [PMID: 17335095]
  172. Cell Host Microbe. 2008 Nov 13;4(5):425-33 [PMID: 18996343]
  173. Adv Exp Med Biol. 1999;473:225-9 [PMID: 10659362]
  174. J Bacteriol. 2004 Jun;186(11):3296-303 [PMID: 15150214]
  175. J Bacteriol. 2010 Jan;192(1):68-76 [PMID: 19880595]
  176. BMC Genomics. 2009 Oct 18;10:481 [PMID: 19835633]
  177. FEBS J. 2005 Sep;272(17):4407-22 [PMID: 16128810]
  178. Infect Immun. 2007 Aug;75(8):3859-67 [PMID: 17517862]
  179. Sci Rep. 2020 Jul 27;10(1):12514 [PMID: 32719325]
  180. J Infect Dis. 1988 Mar;157(3):472-9 [PMID: 3343522]
  181. Eur J Microbiol Immunol (Bp). 2013 Sep;3(3):163-73 [PMID: 24265934]
  182. mBio. 2014 Jul 01;5(4):e01364-14 [PMID: 24987092]
  183. PLoS Med. 2015 Dec 03;12(12):e1001923 [PMID: 26633896]
  184. Infect Immun. 2012 May;80(5):1690-8 [PMID: 22354027]
  185. Can J Microbiol. 2019 Apr;65(4):253-260 [PMID: 30532987]

MeSH Term

Campylobacter jejuni
Campylobacter Infections
Virulence
Humans
Virulence Factors
Animals
Gastroenteritis

Chemicals

Virulence Factors
Journal Article Review
Article has an altmetric score of 1

Word Cloud

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