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Frontiers in microbiology
2024;15 1501373.

Comparative analysis of antimicrobial resistance and genetic diversity of isolates obtained from swine within the United States.

Tracy L Nicholson, Sarah M Shore
Author Information
  1. Tracy L Nicholson: National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, United States.
  2. Sarah M Shore: National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, United States.
PMID: 39669782 DOI: 10.3389/fmicb.2024.1501373

Abstract

Introduction: is bacterial pathogen that is pervasive in swine populations and serves multiple roles in respiratory disease.
Methods: This study utilized whole-genome sequencing (WGS) analysis to assess the sequence type (ST), identify the genetic diversity of genes predicted to encode regulatory and virulence factors, and evaluated any potential antimicrobial resistance harbored by isolates obtained from swine within the U.S.
Results: While a generally high degree of genomic conservation was observed among the swine isolates, genetic diversity was identified within the locus and among the sequence type six (ST6) isolates. The majority of isolates exhibited phenotypic resistance to four antibiotic classes, however, only three antimicrobial resistance genes were identified.
Discussion: Combined the data suggests that isolates are not serving as a source of antimicrobial resistance gene transference in the swine production environment.

Keywords

Bordetella bronchiseptica antimicrobial resistance (AMR) average nucleotide identity (ANI) mobile genetic element (MGE) sequence type (ST) swine virulence factor whole-genome sequencing (WGS)

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