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International journal of molecular sciences
Nov 27, 2024;25 (23):

Functions of TAM Receptors and Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease.

Teagan Prouse, Samarpan Majumder, Rinku Majumder
Author Information
  1. Teagan Prouse: Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. ORCID
  2. Samarpan Majumder: Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. ORCID
  3. Rinku Majumder: Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. ORCID
PMID: 39684449 DOI: 10.3390/ijms252312736

Abstract

Atherosclerosis and cardiovascular disease are associated with high morbidity and mortality in industrialized nations. The Tyro3, Axl, and Mer (TAM) family of receptor tyrosine kinases is involved in the amplification or resolution of atherosclerosis pathology and other cardiovascular pathology. The ligands of these receptors, Protein S (PS) and growth arrest specific protein 6 (Gas6), are essential for TAM receptor functions in the amplification and resolution of atherosclerosis. The Axl-Gas6 interaction has various effects on cardiovascular disease. Mer and PS dampen inflammation, thereby protecting against atherosclerosis progression. Tyro3, the least studied TAM receptor in cardiovascular disease, appears to protect against fibrosis in post-myocardial infarction injury. Ultimately, PS, Gas6, and TAM receptors present an exciting avenue of potential therapeutic targets against inflammation associated with atherosclerosis and cardiovascular disease.

Keywords

Gas6 Protein S TAM receptors apoptosis atherosclerosis cardiovascular disease myocardial infarction

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MeSH Term

Humans
Intercellular Signaling Peptides and Proteins
Protein S
Atherosclerosis
Receptor Protein-Tyrosine Kinases
Animals
Cardiovascular Diseases
Axl Receptor Tyrosine Kinase
c-Mer Tyrosine Kinase
Ligands
Proto-Oncogene Proteins
Inflammation

Chemicals

growth arrest-specific protein 6
Intercellular Signaling Peptides and Proteins
Protein S
Receptor Protein-Tyrosine Kinases
Axl Receptor Tyrosine Kinase
c-Mer Tyrosine Kinase
Ligands
Proto-Oncogene Proteins
AXL protein, human
TYRO3 protein, human
MERTK protein, human
Journal Article Review

Word Cloud

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