A Rare and Life-Threatening Complication of Salmonella Typhi Infection: A Case Report From India Highlighting Diagnostic and Therapeutic Challenges in Salmonella Sepsis.

Jaziya Jabeen, M Ardra, Chithra Valsan, John Paul, Cherish Paul
Author Information
  1. Jaziya Jabeen: Cardiology, Royal Cornwall Hospital, Cornwall, GBR.
  2. M Ardra: Microbiology, Jubilee Mission Medical College & Research Institute, Thrissur, IND.
  3. Chithra Valsan: Microbiology, Jubilee Mission Medical College & Research Institute, Thrissur, IND.
  4. John Paul: Critical Care, Jubilee Mission Medical College & Research Institute, Thrissur, IND.
  5. Cherish Paul: Critical Care, Jubilee Mission Medical College & Research Institute, Thrissur, IND.

Abstract

Salmonella infections are widely known to cause gastroenteritis, especially in areas of poor hygiene and sanitation. Common symptoms include sustained fever, chills, and abdominal pain. Sepsis, disseminated intravascular coagulation (DIC), various neurological manifestations, and multiorgan failure are other uncommon presentations. Raising appropriate awareness about its clinical spectrum is therefore crucial, even in the absence of typical symptoms. The following case of a 34-year-old Indian female who developed -induced sepsis addresses various challenges involved in diagnosing and treating the condition. The case was successfully managed with rapid diagnostics, targeted antibiotic therapy, and supportive care. Recognizing the condition early and providing necessary treatment is therefore vital to preventing substantial morbidity and mortality. To improve outcomes for critically ill patients, it is important that the causative organism be identified quickly and appropriate treatment be commenced. Here, we present a case of Salmonella sepsis complicated by DIC, its clinical course, and the diagnostic and treatment modalities we have followed.

Keywords

References

  1. Clin Infect Dis. 2010 Jan 15;50(2):241-6 [PMID: 20014951]
  2. N Engl J Med. 2002 Nov 28;347(22):1770-82 [PMID: 12456854]
  3. Vaccine. 2015 Jun 19;33 Suppl 3:C8-15 [PMID: 25937611]
  4. Lancet. 2017 Dec 2;390(10111):2472-2480 [PMID: 28965718]
  5. Chest. 2017 Aug;152(2):424-434 [PMID: 28442312]
  6. J Infect. 2001 Jul;43(1):19 [PMID: 11597152]
  7. Vaccine. 2016 Jun 3;34(26):2907-2910 [PMID: 27032517]
  8. Lancet Infect Dis. 2019 Apr;19(4):369-381 [PMID: 30792131]
  9. Ann Med Surg (Lond). 2022 Jan 03;73:103226 [PMID: 35079365]
  10. J Glob Health. 2015 Dec;5(2):020407 [PMID: 26649174]
  11. Lancet. 2015 Mar 21;385(9973):1136-45 [PMID: 25458731]
  12. Am J Trop Med Hyg. 2018 Sep;99(3_Suppl):89-96 [PMID: 30047361]
  13. Clin Infect Dis. 2019 Mar 7;68(Suppl 2):S165-S170 [PMID: 30845331]
  14. JAMA. 2016 Feb 23;315(8):801-10 [PMID: 26903338]
  15. Ther Apher Dial. 2010 Apr;14(2):226-9 [PMID: 20438547]
  16. Intensive Care Med. 2017 Mar;43(3):304-377 [PMID: 28101605]
  17. BMJ. 2021 Feb 26;372:n437 [PMID: 33637488]

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