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Dec 26, 2024;7 (1): 1702.

Function of orexin-1 receptor signaling in the olfactory tubercle in odor-guided attraction and aversion.

Md Monjurul Ahasan, Md Tasnim Alam, Yoshihiro Murata, Mutsuo Taniguchi, Masahiro Yamaguchi
Author Information
  1. Md Monjurul Ahasan: Department of Physiology, Kochi Medical School, Kochi University, Kochi, Japan.
  2. Md Tasnim Alam: Department of Physiology, Kochi Medical School, Kochi University, Kochi, Japan.
  3. Yoshihiro Murata: Department of Physiology, Kochi Medical School, Kochi University, Kochi, Japan. ORCID
  4. Mutsuo Taniguchi: Department of Physiology, Kochi Medical School, Kochi University, Kochi, Japan.
  5. Masahiro Yamaguchi: Department of Physiology, Kochi Medical School, Kochi University, Kochi, Japan. yamaguchi@kochi-u.ac.jp. ORCID
PMID: 39725686 DOI: 10.1038/s42003-024-07438-1

Abstract

While olfactory behaviors are influenced by neuromodulatory signals, the underlying mechanism remains unknown. The olfactory tubercle (OT), a component of the olfactory cortex and ventral striatum, consists of anteromedial (am) and lateral (l) domains regulating odor-guided attractive and aversive behaviors, respectively, in which the amOT highly expresses various receptors for feeding-regulated neuromodulators. Here we show functions of appetite-stimulating orexin-1 receptor (OxR1) signaling in the amOT. When odor-food reward associated mice underwent OxR1 antagonist injection in the amOT, their odor-attractive behavior was suppressed and odor-aversive behavior was conversely induced. Although odor-attractive mice showed activation of attraction-promoting dopamine receptor type 1-expressing D1 cells in the amOT, the antagonist injection increased activation of aversion-promoting D2 cells in the amOT and D1 cells in the lOT. The results highlight the amOT as the crucial structure integrating OxR1 signaling and odor information, thereby controlling metabolic status-dependent olfactory behavior through the cell type- and domain-specific activation.

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Grants

  1. 22H02734/MEXT | Japan Society for the Promotion of Science (JSPS)

MeSH Term

Animals
Orexin Receptors
Mice
Signal Transduction
Male
Odorants
Olfactory Tubercle
Mice, Inbred C57BL
Orexin Receptor Antagonists
Smell
Behavior, Animal
Receptors, Dopamine D1

Chemicals

Orexin Receptors
Orexin Receptor Antagonists
Receptors, Dopamine D1
Journal Article
Article has an altmetric score of 1

Word Cloud

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