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Journal of translational medicine
Jan 06, 2025;23 (1): 19.

Single-cell RNA sequencing highlights the unique tumor microenvironment of small cell neuroendocrine cervical carcinoma.

Tianyou Wang, Li Zhang, Song Mei, Bo Wang, Jiaqi Liu, Weiping Yang, Jiongbo Liao, Chao Wang
Author Information
  1. Tianyou Wang: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
  2. Li Zhang: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
  3. Song Mei: Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  4. Bo Wang: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
  5. Jiaqi Liu: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
  6. Weiping Yang: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
  7. Jiongbo Liao: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. liaojiongbo@163.com.
  8. Chao Wang: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. wang1980-55@163.com.
PMID: 39762893 DOI: 10.1186/s12967-024-05977-z

Abstract

Small cell neuroendocrine cervical carcinoma is a highly aggressive tumor characterized by early metastasis, a high recurrence rate, and poor prognosis. This study represents the first instance of single-cell sequencing conducted on small cell neuroendocrine carcinoma of the cervix worldwide. Analysis of gene expression regulatory networks revealed that the transcription factor TFF3 drived up-regulation of ELF3. Furthermore, our findings indicated that the neuroendocrine marker genes and gene regulatory networks associated with Small cell neuroendocrine cervical carcinoma differed from those observed in lung, small intestine, and liver neuroendocrine carcinoma within the GEO database, suggesting tissue-specific origins for these malignancies. Overall, this study addresses a significant research in understanding Small cell neuroendocrine cervical carcinoma in vivo and provides valuable insights for guiding radiotherapy, chemotherapy, and targeted therapy.

Keywords

Cervical cancer Neuroendocrine Single-nucleus RNA sequencing Tumor microenvironment

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Grants

  1. (General Program/National Natural Science Foundation of China
  2. 82273233); Natural Science Foundation of Shanghai (22ZR1408900); National Natural Science Foundation of China (General Program/National Natural Science Foundation of China
  3. 81772777); Clinical Research Plan of SHDC (No. SHDC2020CR4079); Shanghai "Rising Stars of Medical Talent" Youth Development Program-Outstanding Youth Medical Talents (SHWJRS2021-99)/National Natural Science Foundation of China
  4. Shanghai Science/National Natural Science Foundation of China
  5. technology committee medical guidance program (18411963700)./National Natural Science Foundation of China

MeSH Term

Humans
Uterine Cervical Neoplasms
Female
Tumor Microenvironment
Single-Cell Analysis
Gene Expression Regulation, Neoplastic
Carcinoma, Neuroendocrine
Gene Regulatory Networks
Carcinoma, Small Cell
Sequence Analysis, RNA
Gene Expression Profiling
Journal Article

Word Cloud

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