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Biomolecules
Dec 09, 2024;14 (12):

Polyamine Metabolism and Functions: Key Roles in Cellular Health and Disease.

Marianna Nicoletta Rossi, Manuela Cervelli
Author Information
  1. Marianna Nicoletta Rossi: Department of Sciences, University of Roma Tre, 00146 Rome, Italy. ORCID
  2. Manuela Cervelli: Department of Sciences, University of Roma Tre, 00146 Rome, Italy. ORCID
PMID: 39766277 DOI: 10.3390/biom14121570

Abstract

The polyamines putrescine, spermidine, and spermine are polycations ubiquitously present in cells, where they exert pleiotropic functions in cellular mechanisms like proliferation, protein synthesis (through the hypusination of the transcription factor EIF5a), redox balance, autophagy, and different forms of cell death [...].

References

  1. Biomolecules. 2024 Mar 09;14(3): [PMID: 38540746]
  2. Biomolecules. 2023 May 09;13(5): [PMID: 37238673]
  3. Biomolecules. 2023 May 31;13(6): [PMID: 37371496]
  4. Nat Aging. 2022 Dec;2(12):1112-1129 [PMID: 37118547]
  5. Oncogene. 2024 Nov 10;: [PMID: 39523394]
  6. Science. 2018 Jan 26;359(6374): [PMID: 29371440]
  7. Nat Cell Biol. 2024 Sep;26(9):1571-1584 [PMID: 39117797]
  8. Nat Cell Biol. 2009 Nov;11(11):1305-14 [PMID: 19801973]
  9. Nature. 2020 Feb;578(7795):419-424 [PMID: 31996848]
  10. Nat Rev Cancer. 2022 Aug;22(8):467-480 [PMID: 35477776]
  11. Biomolecules. 2023 Feb 04;13(2): [PMID: 36830667]
  12. Amino Acids. 2020 Feb;52(2):129-139 [PMID: 31197571]
  13. Cells. 2018 Dec 18;7(12): [PMID: 30567412]
  14. Nature. 2017 Jul 6;547(7661):109-113 [PMID: 28658205]
  15. J Mol Evol. 2013 Jun;76(6):365-70 [PMID: 23828398]
  16. Front Cell Dev Biol. 2023 Jan 23;11:1061570 [PMID: 36755974]
  17. Biomolecules. 2023 Dec 15;13(12): [PMID: 38136670]
  18. Nat Rev Cancer. 2018 Nov;18(11):681-695 [PMID: 30181570]
  19. Stroke. 2005 Dec;36(12):2609-13 [PMID: 16269634]
  20. Biomolecules. 2023 Feb 09;13(2): [PMID: 36830711]
  21. Int J Biochem Cell Biol. 2009 Apr;41(4):934-44 [PMID: 18852063]
  22. Nat Rev Microbiol. 2018 Jun;16(6):355-367 [PMID: 29599457]
  23. Biomolecules. 2023 Sep 12;13(9): [PMID: 37759783]
  24. Adv Sci (Weinh). 2022 Mar;9(8):e2104012 [PMID: 35077010]
  25. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31198-31207 [PMID: 33229544]
  26. Pharmaceutics. 2023 Jan 03;15(1): [PMID: 36678796]
  27. Int J Oncol. 2013 Sep;43(3):813-20 [PMID: 23857253]
  28. Biomolecules. 2024 Mar 19;14(3): [PMID: 38540790]
  29. Am J Physiol Cell Physiol. 2024 Aug 1;327(2):C341-C356 [PMID: 38881422]
  30. Cell Biosci. 2024 Jun 25;14(1):84 [PMID: 38918813]
  31. Biomolecules. 2023 May 31;13(6): [PMID: 37371498]
  32. Biomolecules. 2024 Feb 02;14(2): [PMID: 38397415]
  33. Biomolecules. 2023 Apr 21;13(4): [PMID: 37189460]
  34. J Enzyme Inhib Med Chem. 2019 Dec;34(1):740-752 [PMID: 30829081]
  35. Mol Neurobiol. 2018 Sep;55(9):7259-7270 [PMID: 29397558]
  36. Brain Res. 2007 May 11;1145:150-6 [PMID: 17362887]
  37. Amino Acids. 2014 Mar;46(3):521-30 [PMID: 23933909]
  38. Sci Adv. 2018 Jan 24;4(1):eaar2606 [PMID: 29376126]

MeSH Term

Humans
Polyamines
Animals
Autophagy
Eukaryotic Translation Initiation Factor 5A

Chemicals

Polyamines
Eukaryotic Translation Initiation Factor 5A
Editorial Introductory Journal Article

Word Cloud

Created with Highcharts 10.0.0polyaminesputrescinespermidinesperminepolycationsubiquitouslypresentcellsexertpleiotropicfunctionscellularmechanismslikeproliferationproteinsynthesishypusinationtranscriptionfactorEIF5aredoxbalanceautophagydifferentformscelldeath[]PolyamineMetabolismFunctions:KeyRolesCellularHealthDisease

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