Effectiveness of rehabilitation in hospitalized hemodialysis patients as compared with rehabilitation in hospitalized patients not on hemodialysis: a retrospective cohort study.

Ren Takahashi, Hiroki Yabe, Hideaki Ishikawa, Takashi Hibino, Akio Suzumura, Tetsuya Yamada
Author Information
  1. Ren Takahashi: Department of Rehabilitation, Kaikoukai Josai Hospital, Nagoya, Aichi, Japan. 16RP24@g.seirei.ac.jp. ORCID
  2. Hiroki Yabe: Department of Physical Therapy, Seirei Christopher University, School of Rehabilitation, Hamamatsu, Shizuoka, Japan.
  3. Hideaki Ishikawa: Department of Internal Medicine, Kaikoukai Josai Hospital, Nagoya, Aichi, Japan.
  4. Takashi Hibino: Department of Rehabilitation, Kaikoukai Josai Hospital, Nagoya, Aichi, Japan.
  5. Akio Suzumura: Department of Neurology, Kaikoukai Josai Hospital, Nagoya, Aichi, Japan.
  6. Tetsuya Yamada: Dialysis Division, Kaikoukai Healthcare Group, Nagoya, Aichi, Japan.

Abstract

BACKGROUND: The effectiveness of rehabilitation aimed at improving the activities of daily living and physical functions may differ between hospitalized patients undergoing hemodialysis (HD) and not undergoing HD (non-HD). The aim of the present study was to compare the outcomes of rehabilitation between hospitalized HD and non-HD patients.
METHODS: This was a retrospective cohort study of inpatients who underwent rehabilitation. We measured the rehabilitation time (min/day), length of hospital stay (days), and the Barthel index (BI). In addition, at the time of admission and discharge, grip strength, isometric knee extension strength, 10 m walking speed, timed up and go test, and short physical performance battery were examined. The outcomes were then compared between the HD and non-HD groups.
RESULTS: This study was made up of 902 patients (non-HD group: 765, HD group: 137). Our analysis revealed a lower rehabilitation time [43.3 (0.6) vs. 38.8 (1.2) min/day] and longer hospital stay [48.5 (0.5) vs. 58.1 (2.3) days] in the HD group as compared with the non-HD group (p < 0.05). In addition, the 10 m walking speed [0.75 (0.02) vs. 0.66 (0.03) m/s], timed up and go test [20.8 (0.7) vs. 24.3 (1.0) sec], and short physical performance battery [6.3 (0.6) vs. 4.7 (0.6) points] at discharge were also significantly lower in the HD group as compared with the non-HD group (p < 0.05).
CONCLUSION: Rehabilitation efforts for HD patients need to be improved by securing more time for inpatient rehabilitation and promoting mobility function improvement for these patients.

Keywords

References

  1. Sá Martins V, Adragão T, Aguiar L et al (2022) Prognostic value of the malnutrition-inflammation score in hospitalization and mortality on long-term hemodialysis. J Ren Nutr 32:569–577. https://doi.org/10.1053/j.jrn.2021.11.002 [DOI: 10.1053/j.jrn.2021.11.002]
  2. Cobo G, Lindholm B, Stenvinkel P (2018) Chronic inflammation in end-stage renal disease and dialysis. Nephrol Dial Transplant 33(suppl_3):iii35–iii40. https://doi.org/10.1093/ndt/gfy175 [DOI: 10.1093/ndt/gfy175]
  3. Lim YJ, Sidor NA, Tonial NC, Che A, Urquhart BL (2021) Uremic toxins in the progression of chronic kidney disease and cardiovascular disease: mechanisms and therapeutic targets. Toxins 13:142. https://doi.org/10.3390/toxins13020142 [DOI: 10.3390/toxins13020142]
  4. Van Gelder MK, Abrahams AC, Joles JA, Kaysen GA, Gerritsen KGF (2018) Albumin handling in different hemodialysis modalities. Nephrol Dial Transplant 33:906–913. https://doi.org/10.1093/ndt/gfx191 [DOI: 10.1093/ndt/gfx191]
  5. United States Renal Data System (2022) USRDS Annual Data Report: Epidemiology of kidney disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. https://usrds-adr.niddk.nih.gov/2023/suggested-citation . Accessed 20 Jun 2024
  6. Xu Y, Li L, Evans M, Xu H, Lindholm B, Carrero JJ (2021) Burden and causes of hospital admissions and readmissions in patients undergoing hemodialysis and peritoneal dialysis: a nationwide study. J Nephrol 34:1949–1959. https://doi.org/10.1007/s40620-021-01023-z [DOI: 10.1007/s40620-021-01023-z]
  7. Chavers BM, Solid CA, Gilbertson DT, Collins AJ (2007) Infection-related hospitalization rates in pediatric versus adult patients with end-stage renal disease in the United States. J Am Soc Nephrol 18:952–959. https://doi.org/10.1681/ASN.2006040406 [DOI: 10.1681/ASN.2006040406]
  8. Dalrymple LS, Mu Y, Nguyen DV, Romano PS, Chertow GM, Grimes B, Kaysen GA, Johansen KL (2015) Risk factors for infection-related hospitalization in in-center hemodialysis. Clin J Am Soc Nephrol 10:2170–2180. https://doi.org/10.2215/CJN.03050315 [DOI: 10.2215/CJN.03050315]
  9. Tentori F, McCullough K, Kilpatrick RD, Bradbury BD, Robinson BM, Kerr PG, Pisoni RL (2014) High rates of death and hospitalization follow bone fracture among hemodialysis patients. Kidney Int 85:166–173. https://doi.org/10.1038/ki.2013.279 [DOI: 10.1038/ki.2013.279]
  10. Cook WL, Jassal SV (2008) Functional dependencies among the elderly on hemodialysis. Kidney Int 73:1289–1295. https://doi.org/10.1038/ki.2008.62 [DOI: 10.1038/ki.2008.62]
  11. Sood MM, Rigatto C, Bueti J, Jassal V, Miller L, Verrelli M, Bohm C, Mojica J, Roberts D, Komenda P (2011) The role of functional status in discharge to assisted care facilities and in-hospital death among dialysis patients. Am J Kidney Dis 58:804–812. https://doi.org/10.1053/j.ajkd.2011.06.017 [DOI: 10.1053/j.ajkd.2011.06.017]
  12. Kamitani T, Fukuma S, Shimizu S, Akizawa T, Fukuhara S (2020) Length of hospital stay is associated with a decline in activities of daily living in hemodialysis patients: a prospective cohort study. BMC Nephrol 21:9. https://doi.org/10.1186/s12882-019-1674-6 [DOI: 10.1186/s12882-019-1674-6]
  13. Japanese Society of Physical Therapy for Diabetes Mellitus (2016) Survey of Physical Therapists’ Involvement in Patients with Diabetic Foot Lesions and Diabetic Nephropathy. https://www.japanpt.or.jp/assets/pdf/activity/investigation/tounyou_houkokusyo_2016.pdf . Accessed 20 Jun 2024
  14. Forrest G, Nagao M, Iqbal A, Kakar R (2005) Inpatient rehabilitation of patients requiring hemodialysis: improving efficiency of care. Arch Phys Med Rehabil 86:1949–1952. https://doi.org/10.1016/j.apmr.2005.04.006 [DOI: 10.1016/j.apmr.2005.04.006]
  15. Kenichi K, Makoto I, Nomura T, Mori K, Hiraki K, Hayashi H et al (2022) Physical function of outpatients and inpatients on dialysis who received physical therapy: an exploratory, cross-sectional study by JSPTDM. J Allied Health 13:10–15. https://doi.org/10.15563/jalliedhealthsci.13.10 [DOI: 10.15563/jalliedhealthsci.13.10]
  16. Koh GC, Chen CH, Petrella R, Thind A (2013) Rehabilitation impact indices and their independent predictors: a systematic review. BMJ Open 3:e003483. https://doi.org/10.1136/bmjopen-2013-003483 [DOI: 10.1136/bmjopen-2013-003483]
  17. Yao XI, Wang X, Speicher PJ, Hwang ES, Cheng P, Harpole DH, Berry MF, Schrag D, Pang HH (2017) Reporting and guidelines in propensity score analysis: A systematic review of cancer and cancer surgical studies. J Natl Cancer Inst Monogr 109:djw323. https://doi.org/10.1093/jnci/djw323 [DOI: 10.1093/jnci/djw323]
  18. Strini V, Piazzetta N, Gallo A, Schiavolin R (2020) Barthel Index: creation and validation of two cut-offs using the BRASS Index. Acta Bio Med Atenei Parmensis 91:19–26. https://doi.org/10.23750/abm.v91i2-S.9226 [DOI: 10.23750/abm.v91i2-S.9226]
  19. Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Arai H (2020) Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc 21:300-307.e2. https://doi.org/10.1016/j.jamda.2019.12.012 [DOI: 10.1016/j.jamda.2019.12.012]
  20. Matsuzawa R, Roshanravan B (2018) Management of physical frailty in patients requiring hemodialysis therapy. Contrib Nephrol 196:101–109. https://doi.org/10.1159/000485707 [DOI: 10.1159/000485707]
  21. Rose DJ, Jones CJ, Lucchese N (2002) Predicting the probability of falls in community-residing older adults using the 8-foot up-and-go: a new measure of functional mobility. J Aging Phys Act 10:466–475 [DOI: 10.1123/japa.10.4.466]
  22. Shinjo G, Otaka Y, Muraoka K, Ebata H, Liu M (2020) Functional outcomes of rehabilitation in patients with subacute stroke on haemodialysis. J Rehabil Med 52:jrm00033. https://doi.org/10.2340/16501977-2646 [DOI: 10.2340/16501977-2646]
  23. Kwakkel G, van Peppen R, Wagenaar RC, Wood Dauphinee S, Richards C, Ashburn A, Miller K, Lincoln N, Partridge C, Wellwood I, Langhorne P (2004) Effects of augmented exercise therapy time after stroke: a meta-analysis. Stroke 35:2529–2539 [DOI: 10.1161/01.STR.0000143153.76460.7d]
  24. Piva S, Farrokhi S, Almeida GGK, Levison T, DiGioia A (2016) Dose-associated changes in gait parameters in response to exercise programs after total knee arthroplasty: secondary analysis of two randomized studies. Int J Phys Med Rehabil 3:3–7. https://doi.org/10.4172/2329-9096.1000311 [DOI: 10.4172/2329-9096.1000311]
  25. Woo H, Lee S, Lee H, Chae H, Jung J, Song M, Lim S, Lee Y, Cho Y, Kim E, Kim H, Lim J, Song K, Beom J (2022) Comprehensive rehabilitation in severely ill inpatients with COVID-19: a cohort study in a tertiary hospital. J Korean Med Sci. https://doi.org/10.3346/jkms.2022.37.e262 [DOI: 10.3346/jkms.2022.37.e262]
  26. Li M, Porter E, Lam R, Jassal SV (2007) Quality improvement through the introduction of interdisciplinary geriatric hemodialysis rehabilitation care. Am J Kidney Dis 50:90–97. https://doi.org/10.1053/j.ajkd.2007.04.011 [DOI: 10.1053/j.ajkd.2007.04.011]
  27. Joki N, Tokumoto M, Takahashi N, Nishimura M (2018) Current perspectives on sudden cardiac death in hemodialysis patients. Contrib Nephrol 196:5–12. https://doi.org/10.1159/000485690 [DOI: 10.1159/000485690]
  28. Shoji T, Tsubakihara Y, Fujii M, Imai E (2004) Hemodialysis-associated hypotension as an independent risk factor for two-year mortality in hemodialysis patients. Kidney Int 66:1212–1220. https://doi.org/10.1111/j.1523-1755.2004.00812.x [DOI: 10.1111/j.1523-1755.2004.00812.x]
  29. Dou J, Liu H, Ma Y, Wu YY, Tao XB (2023) Prevalence of post-dialysis fatigue: a systematic review and meta-analysis. BMJ Open 13:e064174. https://doi.org/10.1136/bmjopen-2022-064174 [DOI: 10.1136/bmjopen-2022-064174]
  30. Takahashi R, Yabe H, Ishikawa H, Hibino T, Morishita S, Kono K, Moriyama Y, Yamada T (2024) The impact of malnutrition on the effectiveness of intradialytic exercise in hemodialysis patients: a multicenter cohort study. Int Urol Nephrol 56:2093–2101. https://doi.org/10.1007/s11255-024-03952-7 [DOI: 10.1007/s11255-024-03952-7]
  31. Sabatino A, Cuppari L, Stenvinkel P, Lindholm B, Avesani CM (2021) Sarcopenia in chronic kidney disease: what have we learned so far? J Nephrol 34:1347–1372. https://doi.org/10.1007/s40620-020-00840-y [DOI: 10.1007/s40620-020-00840-y]
  32. Dos Santos PR, Mendonça CR, Hernandes JC, Borges CC, Barbosa MA, Romeiro AMS, Alves PM, Dias NT, Porto CC (2021) Pain in patients with chronic kidney disease undergoing hemodialysis: a systematic review. Pain Manag Nurs 22:605–615. https://doi.org/10.1016/j.pmn.2021.05.009 [DOI: 10.1016/j.pmn.2021.05.009]
  33. Majchrzak KM, Pupim LB, Chen K, Martin CJ, Gaffney S, Greene JH, Ikizler TA (2005) Physical activity patterns in chronic hemodialysis patients: comparison of dialysis and nondialysis days. J Ren Nutr 15:217–224. https://doi.org/10.1053/j.jrn.2004.08.002 [DOI: 10.1053/j.jrn.2004.08.002]
  34. Ortega-Pérez de Villar L, Martínez-Olmos FJ, Junqué-Jiménez A, Amer-Cuenca JJ, Martínez-Gramage J, Mercer T, Segura-Ortí E (2018) Test-retest reliability and minimal detectable change scores for the short physical performance battery, one-legged standing test and timed up and go test in patients undergoing hemodialysis. PLoS One 13:e0201035. https://doi.org/10.1371/journal.pone.0201035
  35. Palombaro KM, Craik RL, Mangione KK, Tomlinson JD (2006) Determining meaningful changes in gait speed after hip fracture. Phys Ther 86:809–816 [DOI: 10.1093/ptj/86.6.809]
  36. Desmet C, Beguin C, Swine C, Jadoul M, Université Catholique de Louvain Collaborative Group (2005) Falls in hemodialysis patients: prospective study of incidence, risk factors, and complications. Am J Kidney Dis 45:148–153 [DOI: 10.1053/j.ajkd.2004.09.027]
  37. Kutner NG, Zhang R, Huang Y, Wasse H (2014) Gait speed and hospitalization among ambulatory hemodialysis patients: USRDS special study data. World J Nephrol 3:101–106. https://doi.org/10.5527/wjn.v3.i3.101 [DOI: 10.5527/wjn.v3.i3.101]
  38. Shimizu Y, Fujiura T, Wakabayashi H (2018) Prevalence of nutritional risk and its impact on functional recovery in older inpatients on maintenance hemodialysis: a retrospective single-center cohort study. Ren Replace Ther 4:48. https://doi.org/10.1186/s41100-018-0191-6 [DOI: 10.1186/s41100-018-0191-6]
  39. Yabe H, Nakano H, Yamaguchi T, Takahashi R, Kono K, Moriyama Y, Yamada T (2023) Factors associated with 10-m walking speed in outpatients undergoing hemodialysis: a multicenter cross-sectional study. Ren Replace Ther 9:40. https://doi.org/10.1186/s41100-023-00493-0 [DOI: 10.1186/s41100-023-00493-0]
  40. Bündchen DC, Sousa H, Afreixo V, Frontini R, Ribeiro O, Figueiredo D, Costa E (2021) Intradialytic exercise in end-stage renal disease: an umbrella review of systematic reviews and/or meta-analytical studies. Clin Rehabil 35:812–828. https://doi.org/10.1177/0269215520986784 [DOI: 10.1177/0269215520986784]

MeSH Term

Humans
Retrospective Studies
Male
Renal Dialysis
Female
Middle Aged
Aged
Length of Stay
Activities of Daily Living
Hospitalization
Treatment Outcome
Time Factors
Inpatients
Recovery of Function

Word Cloud

Created with Highcharts 10.0.00rehabilitationHDpatientsnon-HDvshospitalizedstudytimecompared3groupphysical61undergoinghemodialysisoutcomesretrospectivecohorthospitalstayadditiondischargestrength10 mwalkingspeedtimedgotestshortperformancebatterygroup:lower825p < 0057RehabilitationBACKGROUND:effectivenessaimedimprovingactivitiesdailylivingfunctionsmaydifferaimpresentcompareMETHODS:inpatientsunderwentmeasuredmin/daylengthdaysBarthelindexBIadmissiongripisometrickneeextensionexaminedgroupsRESULTS:made902765137analysisrevealed[4338min/day]longer[4858days][075026603m/s][2024sec][64points]alsosignificantlyCONCLUSION:effortsneedimprovedsecuringinpatientpromotingmobilityfunctionimprovementEffectivenesspatients nothemodialysis:HemodialysisHospitalizationMobility

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