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Jan 07, 2025;61 (1):

The Role of Platelet Concentrates and Growth Factors in Facial Rejuvenation: A Systematic Review with Case Series.

Giuseppina Malcangi, Angelo Michele Inchingolo, Alessio Danilo Inchingolo, Laura Ferrante, Giulia Latini, Irma Trilli, Paola Nardelli, Marialuisa Longo, Andrea Palermo, Francesco Inchingolo, Gianna Dipalma
Author Information
  1. Giuseppina Malcangi: Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy. ORCID
  2. Angelo Michele Inchingolo: Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy. ORCID
  3. Alessio Danilo Inchingolo: Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy. ORCID
  4. Laura Ferrante: Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy. ORCID
  5. Giulia Latini: Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
  6. Irma Trilli: Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy. ORCID
  7. Paola Nardelli: Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
  8. Marialuisa Longo: Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
  9. Andrea Palermo: Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy.
  10. Francesco Inchingolo: Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy. ORCID
  11. Gianna Dipalma: Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy. ORCID
PMID: 39859067 DOI: 10.3390/medicina61010084

Abstract

: Due to the regeneration potential of growth factors (GFs) and platelet concentrates (PCs), facial rejuvenation has been a major area of attention in esthetic medicine. The effectiveness and safety of PCs and GFs in promoting face rejuvenation are examined in this systematic review, which is complemented by a case series. GFs are essential for collagen production and dermal matrix remodeling, while PCs, like Platelet-Rich Plasma (PRP), are abundant in bioactive chemicals that promote tissue healing and cellular regeneration. : A comprehensive literature search was performed on PubMed, Web of Science, and Scopus, focusing on human clinical trials published between February 2019 and February 2024 related to PRP and facial esthetics. : Thirteen studies met the inclusion criteria and were analyzed. : The review summarizes the most recent data on patient outcomes, treatment regimens, and possible hazards. The case series that goes with it shows real-world examples of how to improve skin elasticity, texture, and general facial appearance with little negative side effects. These results highlight the potential use of PCs and GFs as minimally invasive procedures.

Keywords

PRP facial esthetic growth factors photoaging regenerative medicine rejuvenation skin skin aging skin degradation wrinkles

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MeSH Term

Humans
Rejuvenation
Intercellular Signaling Peptides and Proteins
Platelet-Rich Plasma
Face
Skin Aging
Cosmetic Techniques
Female

Chemicals

Intercellular Signaling Peptides and Proteins
Systematic Review Journal Article Review
Article has an altmetric score of 1

Word Cloud

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