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Dec 28, 2024;17 (1):

Hospital-Based Surveillance of Respiratory Viruses Among Children Under Five Years of Age with ARI and SARI in Eastern UP, India.

Hirawati Deval, Mitali Srivastava, Neha Srivastava, Niraj Kumar, Aman Agarwal, Varsha Potdar, Anita Mehta, Bhoopendra Sharma, Rohit Beniwal, Rajeev Singh, Amresh Kumar Singh, Vivek Gaur, Mahima Mittal, Gaurav Raj Dwivedi, Sthita Pragnya Behera, Asif Kavathekar, Sanjay Prajapati, Sachin Yadav, Dipti Gautam, Nalin Kumar, Asif Iqbal, Rajni Kant, Manoj Murhekar
Author Information
  1. Hirawati Deval: Molecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, India. ORCID
  2. Mitali Srivastava: Molecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, India.
  3. Neha Srivastava: ICMR-Regional Medical Research Centre, Gorakhpur 273013, India. ORCID
  4. Niraj Kumar: Molecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, India. ORCID
  5. Aman Agarwal: ICMR-Regional Medical Research Centre, Gorakhpur 273013, India. ORCID
  6. Varsha Potdar: National Influenza Centre, ICMR-National Institute of Virology, Pune 411001, India. ORCID
  7. Anita Mehta: Department of Paediatrics, BRD Medical College, Gorakhpur 273013, India.
  8. Bhoopendra Sharma: Department of Paediatrics, BRD Medical College, Gorakhpur 273013, India.
  9. Rohit Beniwal: ICMR-Regional Medical Research Centre, Gorakhpur 273013, India.
  10. Rajeev Singh: ICMR-Regional Medical Research Centre, Gorakhpur 273013, India. ORCID
  11. Amresh Kumar Singh: Department of Microbiology, BRD Medical College, Gorakhpur 273013, India. ORCID
  12. Vivek Gaur: Department of Microbiology, BRD Medical College, Gorakhpur 273013, India. ORCID
  13. Mahima Mittal: Department of Paediatrics, AIIMS, Gorakhpur 273008, India.
  14. Gaurav Raj Dwivedi: ICMR-Regional Medical Research Centre, Gorakhpur 273013, India.
  15. Sthita Pragnya Behera: ICMR-Regional Medical Research Centre, Gorakhpur 273013, India. ORCID
  16. Asif Kavathekar: Molecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, India.
  17. Sanjay Prajapati: Molecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, India.
  18. Sachin Yadav: Molecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, India.
  19. Dipti Gautam: Molecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, India.
  20. Nalin Kumar: Molecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, India.
  21. Asif Iqbal: Molecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, India.
  22. Rajni Kant: ICMR-Regional Medical Research Centre, Gorakhpur 273013, India.
  23. Manoj Murhekar: ICMR-National Institute of Epidemiology, Chennai 600077, India.
PMID: 39861815 DOI: 10.3390/v17010027

Abstract

Acute respiratory infections (ARIs) are a leading cause of death in children under five globally. The seasonal trends and profiles of respiratory viruses vary by region and season. Due to limited information and the population's vulnerability, we conducted the hospital-based surveillance of respiratory viruses in Eastern Uttar Pradesh. Throat and nasal swabs were collected from outpatients and inpatients in the Department of Paediatrics, Baba Raghav Das (BRD) Medical College, Gorakhpur, between May 2022 and April 2023. A total of 943 samples from children aged 1 to 60 months were tested using multiplex real-time PCR for respiratory viruses in cases of ARI and SARI. Out of 943 samples tested, the highest positivity was found for parainfluenza virus [105 (11.13%) PIV-1 (79), PIV-2 (18), PIV-4 (18)], followed by adenovirus [82 (8.7%), RSV-B, [68 (7.21%)], influenza-A [46(4.9%): H1N1 = 29, H3N2 = 14), SARS CoV-2 [28 (3%)], hMPV [13(1.4%), RSV-A [4 (0.42%), and influenza-B (Victoria lineage) 1 (0.10%). The maximum positivity of respiratory viruses was seen in children between 1 to 12 months. The wide variation in prevalence of these respiratory viruses was seen in different seasons. This study enhances understanding of the seasonal and clinical trends of respiratory virus circulation and co-infections in Eastern Uttar Pradesh. The findings highlight the importance of targeted interventions to reduce the burden of respiratory infections in this region.

Keywords

ARI human metapneumovirus (hMPV) parainfluenza virus (PIV) respiratory syncytial virus (RSV) severe acute respiratory infection under 5 children

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Grants

  1. ICMR Extramural Project No. 5/7/1721/CH/Adhoc/2020-RBMCH/ICMR

MeSH Term

Humans
Infant
Respiratory Tract Infections
Child, Preschool
India
Female
Male
Viruses
Seasons
Hospitals
Coinfection
Prevalence
Journal Article

Word Cloud

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