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npj antimicrobials and resistance
Jan 25, 2025;3 (1): 5.

The genus Nocardia as a source of new antimicrobials.

Napawit Nonthakaew, Liam K R Sharkey, Sacha J Pidot
Author Information
  1. Napawit Nonthakaew: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
  2. Liam K R Sharkey: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
  3. Sacha J Pidot: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia. sacha.pidot@unimelb.edu.au.
PMID: 39863791 DOI: 10.1038/s44259-025-00075-6

Abstract

The genus Nocardia comprises over 130 species of soil-dwelling actinomycetes, many of which are opportunistic pathogens. Beyond their pathogenicity, Nocardia exhibits significant biosynthetic potential, producing an array of diverse antimicrobial secondary metabolites. This review highlights notable examples of these compounds and explores modern approaches to unlocking their untapped biosynthetic potential. As a relatively underexplored genus, Nocardia represents a promising source for new antibiotics to combat the growing resistance crisis.

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Grants

  1. GNT2021638/National Health and Medical Research Council
  2. GNT2021638/National Health and Medical Research Council
  3. DP230102668/Australian Research Council
  4. DP220100905/Australian Research Council
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