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Current treatment options in oncology
Feb, 2025;26 (2): 103-127.

Advancements in Diagnosis and Treatment of Cardiac Sarcomas: A Comprehensive Review.

Xuezhe Wang, Xinchi Luan, Wenwen Yin, Yilin Wang, Xiaoxuan Li, Ruolan Chen, Guoliang Zhang, Ruizhe Zhao, Xue Dong, Zhishang Zhang, Yuchen Fan, Zhaodong Li, Xianming Chu, Shuang Wang
Author Information
  1. Xuezhe Wang: Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
  2. Xinchi Luan: Department of Oncology, Key Laboratory of Cancer Molecular and Translational Research, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
  3. Wenwen Yin: Department of Pulmonology, The Sixth Affiliated Hospital of Qingdao University, Weihai, Shandong, China.
  4. Yilin Wang: School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
  5. Xiaoxuan Li: Department of Oncology, Key Laboratory of Cancer Molecular and Translational Research, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
  6. Ruolan Chen: Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
  7. Guoliang Zhang: Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
  8. Ruizhe Zhao: School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
  9. Xue Dong: School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
  10. Zhishang Zhang: Department of Joint Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
  11. Yuchen Fan: School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
  12. Zhaodong Li: School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
  13. Xianming Chu: Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China. chuxianming@qdu.edu.cn.
  14. Shuang Wang: School of Basic Medicine, Qingdao University, Qingdao, Shandong, China. wangshuang85@qdu.edu.cn.
PMID: 39885109 DOI: 10.1007/s11864-024-01287-0

Abstract

OPINION STATEMENT: Cardiac Sarcomas are rare, aggressive malignancies originating from various cardiac cell types, presenting significant challenges in both diagnosis and treatment. This comprehensive review explores recent advancements in diagnosis and treatment of cardiac angiosarcoma, fibrosarcoma, leiomyosarcoma, and rhabdomyosarcoma. And we briefly discuss the exceedingly rare occurrence of cardiac osteosarcoma and present our perspectives on its treatment. Development of these tumors is influenced by genetic mutations, environmental factors, and chromosomal abnormalities, necessitating a multidisciplinary approach for accurate diagnosis and management. Advanced imaging techniques, biomarkers, and immunohistochemical analysis assist in confirming the diagnosis and guiding treatment decisions. Surgical resection, adjuvant therapies, and personalized treatment strategies based on genetic profiling offer promising avenues for improving patient outcomes. Emerging therapeutic approaches, such as targeted therapies and immunotherapies, have shown promising progress in recent years. Despite these advancements, the prognosis for patient with Cardiac Sarcomas remains poor, highlighting the urgent need for continued research to refine treatment methods and enhance long-term survival outcomes. Ongoing efforts and clinical trials are essential for advancing the management of these rare and aggressive tumors, ultimately improving quality of life for affected patients.

Keywords

Cardiac sarcomas Diagnosis Etiology Prognostic Effect Treatment

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MeSH Term

Humans
Heart Neoplasms
Sarcoma
Disease Management
Combined Modality Therapy
Prognosis
Biomarkers, Tumor
Treatment Outcome
Disease Susceptibility

Chemicals

Biomarkers, Tumor
Journal Article Review

Word Cloud

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