Mapping Fear-Related Neural Activity and Circuitry Changes Following Prophylactic Administration of (R,S)-Ketamine and (2S,6S)-Hydroxynorketamine.
Minzhu Li, Li Cheng
Author Information
- Minzhu Li: Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang Chinese Medical University, Hangzhou, 310053, China.
- Li Cheng: Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang Chinese Medical University, Hangzhou, 310053, China. cheng_li@zju.edu.cn. ORCID
No abstract text available.
- Merians AN, Spiller T, Harpaz-Rotem I, Krystal JH, Pietrzak RH. Post-traumatic stress disorder. Med Clin N Am 2023, 107: 85���99.
[DOI: 10.1016/j.mcna.2022.04.003]
- Mastrodonato A, Pavlova I, Kee NC, Pham VA, McGowan JC, Mann JJ. Prophylactic (R, S)-ketamine is effective against stress-induced behaviors in adolescent but not aged mice. Int J Neuropsychopharmacol 2022, 25: 512���523.
[DOI: 10.1093/ijnp/pyac020]
- Ma JH, Wang SY, Yu HY, Li DY, Luo SC, Zheng SS, et al. Prophylactic use of ketamine reduces postpartum depression in Chinese women undergoing cesarean section ���. Psychiatry Res 2019, 279: 252���258.
[DOI: 10.1016/j.psychres.2019.03.026]
- Chen BK, Luna VM, LaGamma CT, Xu X, Deng SX, Suckow RF, et al. Sex-specific neurobiological actions of prophylactic (R, S)-ketamine, (2R, 6R)-hydroxynorketamine, and (2S, 6S)-hydroxynorketamine. Neuropsychopharmacology 2020, 45: 1545���1556.
[DOI: 10.1038/s41386-020-0714-z]
- Mastrodonato A, Jin M, Kee N, Lanio M, Tapia J, Quintana L, et al. Prophylactic (R, S)-ketamine and (2S, 6S)-hydroxynorketamine decrease fear expression by differentially modulating fear neural ensembles. Biol Psychiatry 2024, S0006���3223(24): 01649���01654.
- Pastuzyn ED, Day CE, Kearns RB, Kyrke-Smith M, Taibi AV, McCormick J, et al. The neuronal gene arc encodes a repurposed retrotransposon gag protein that mediates intercellular RNA transfer. Cell 2018, 172: 275-288.e18.
[DOI: 10.1016/j.cell.2017.12.024]
- Liu RJ, Ota KT, Dutheil S, Duman RS, Aghajanian GK. Ketamine strengthens CRF-activated amygdala inputs to basal dendrites in mPFC layer V pyramidal cells in the prelimbic but not infralimbic subregion, A key suppressor of stress responses. Neuropsychopharmacology 2015, 40: 2066���2075.
[DOI: 10.1038/npp.2015.70]
- Vann SD, Aggleton JP, Maguire EA. What does the retrosplenial cortex do? Nat Rev Neurosci 2009, 10: 792���802.
[DOI: 10.1038/nrn2733]
- Hess EM, Riggs LM, Michaelides M, Gould TD. Mechanisms of ketamine and its metabolites as antidepressants. Biochem Pharmacol 2022, 197: 114892.
[DOI: 10.1016/j.bcp.2021.114892]
- Hare BD, Duman RS. Prefrontal cortex circuits in depression and anxiety: Contribution of discrete neuronal populations and target regions. Mol Psychiatry 2020, 25: 2742���2758.
[DOI: 10.1038/s41380-020-0685-9]
