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Frontiers in public health
2025;13 1531546.

Low-dose ionizing radiation and the exposure-lag response: protocol for a prospective cohort study on The Health Effects of Chongqing Occupational Radiation Workers.

Xiao-Ling Qin, Qiang Huang, Han-Wen Zhang, Yi Zeng, Xian-Shu Lin, Xiao-Yuan Fan, Jun Diao, Cheng-Zhi Chen, Shu-Qun Cheng, Fang Yuan, Jun-Lin He, Wei Li, Yin-Yin Xia
Author Information
  1. Xiao-Ling Qin: School of Public Health, Chongqing Medical University, Chongqing, China.
  2. Qiang Huang: Chongqing Center for Disease Control and Prevention, Chongqing, China.
  3. Han-Wen Zhang: Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  4. Yi Zeng: School of Public Health, Chongqing Medical University, Chongqing, China.
  5. Xian-Shu Lin: School of Public Health, Chongqing Medical University, Chongqing, China.
  6. Xiao-Yuan Fan: School of Public Health, Chongqing Medical University, Chongqing, China.
  7. Jun Diao: Chongqing Jiulongpo District Center for Disease Control and Prevention, Chongqing, China.
  8. Cheng-Zhi Chen: School of Public Health, Chongqing Medical University, Chongqing, China.
  9. Shu-Qun Cheng: School of Public Health, Chongqing Medical University, Chongqing, China.
  10. Fang Yuan: Chongqing Center for Disease Control and Prevention, Chongqing, China.
  11. Jun-Lin He: School of Public Health, Chongqing Medical University, Chongqing, China.
  12. Wei Li: Chongqing Center for Disease Control and Prevention, Chongqing, China.
  13. Yin-Yin Xia: School of Public Health, Chongqing Medical University, Chongqing, China.
PMID: 39931302 DOI: 10.3389/fpubh.2025.1531546

Abstract

Introduction: Although the effects of ionizing radiation on radiation workers have been extensively studied in China, no prospective cohort study has been conducted in Chongqing. Furthermore, previous cohorts have not provided a broad-gauge assessment of the temporal relationship between low-dose occupational radiation exposure and the risk of health outcomes.
Methods: A prospective cohort study will be carried out focusing on radiation workers in Chongqing. Health examination outcomes and radiation dose monitoring data will be collected and analyzed using the distributed lag non-linear model (DLNM) combined with generalized additive model (GAM) or generalized linear model (GLM) to evaluate the exposure-lag response relationship.
Discussion: Our study will enhance our understanding of the exposure-lag response association between occupational radiation exposure and the health of radiation workers based on DLNM.
Clinical trial registration: Chinese Clinical Trials Registry, ChiCTR2400081804.

Keywords

cohort distributed lag non-linear model exposure–lag response low-dose ionizing radiation radiation workers

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MeSH Term

Humans
Prospective Studies
China
Radiation, Ionizing
Occupational Exposure
Male
Adult
Female
Radiation Exposure
Middle Aged
Radiation Dosage
Journal Article
Article has an altmetric score of 1

Word Cloud

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