OpenLB
Open Library of Bioscience
Advanced Search
Infection
Feb 11, 2025;

Panoramic quantitative and visualization-based bibliometric analysis of Mycoplasma pneumoniae.

Jun Wang, Mo Wu, Mei Liu, Wenbin Tuo, Yu Shang, Yuxuan Tao, Tian Chen, Cong Yao, Zhen Xie, Yun Xiang, Qinzhen Cai, Chunhui Yuan
Author Information
  1. Jun Wang: Department of Laboratory Medicine, Tongji Medical College, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Huazhong University of Science & Technology, Wuhan, Hubei, 430016, P.R. China.
  2. Mo Wu: Department of Laboratory Medicine, Tongji Medical College, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Huazhong University of Science & Technology, Wuhan, Hubei, 430016, P.R. China.
  3. Mei Liu: Department of Laboratory Medicine, Wuhan Hankou Hospital, Wuhan, Hubei, 430012, P.R. China.
  4. Wenbin Tuo: Department of Laboratory Medicine, Tongji Medical College, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Huazhong University of Science & Technology, Wuhan, Hubei, 430016, P.R. China.
  5. Yu Shang: Department of Laboratory Medicine, Tongji Medical College, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Huazhong University of Science & Technology, Wuhan, Hubei, 430016, P.R. China.
  6. Yuxuan Tao: Department of Laboratory Medicine, Tongji Medical College, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Huazhong University of Science & Technology, Wuhan, Hubei, 430016, P.R. China.
  7. Tian Chen: Department of Laboratory Medicine, Tongji Medical College, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Huazhong University of Science & Technology, Wuhan, Hubei, 430016, P.R. China.
  8. Cong Yao: Health Care Department, Tongji Medical College, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Huazhong University of Science & Technology, Wuhan, P.R. China.
  9. Zhen Xie: Department of Laboratory Medicine, The Fifth Hospital of Wuhan, Wuhan, P.R. China.
  10. Yun Xiang: Department of Laboratory Medicine, Tongji Medical College, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Huazhong University of Science & Technology, Wuhan, Hubei, 430016, P.R. China. xiangyun5272008@163.com.
  11. Qinzhen Cai: Department of Laboratory Medicine, Tongji Medical College, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Huazhong University of Science & Technology, Wuhan, Hubei, 430016, P.R. China. cai200504046@126.com.
  12. Chunhui Yuan: Department of Laboratory Medicine, Tongji Medical College, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Huazhong University of Science & Technology, Wuhan, Hubei, 430016, P.R. China. chunhuii.yuen@whu.edu.cn.
PMID: 39934470 DOI: 10.1007/s15010-025-02482-3

Abstract

PURPOSE: Severe pneumonia, refractory pneumonia and extrapulmonary complications caused by Mycoplasma pneumoniae infection were increasing, posing a serious threat to health. This study aimed to explore a breakthrough for further investigations in further.
METHODS: The Web of Science Core Collection was queried using the search term TS = "Mycoplasma pneumoniae" for articles from January 1, 2009, to September 24, 2024. Bibliometric indicators were analyzed using VOSviewer, Pajek, and Scimago Graphica, while CiteSpace was utilized for visual analyses, including the contributions of different countries/regions, institutions, authorship patterns, journals, co-citations, keywords, and genes.
RESULTS: 3,093 articles were collected and showed an increase interest in MPP research. China was the most prolific contributor, and the USA demonstrated the strongest collaboration willingness. The USA and China had the highest cooperation frequency and closest research relationship. The UK had the highest single-article citation count. Fudan University had the greatest total link strength. The top keywords were "Mycoplasma pneumoniae" and "community-acquired pneumonia", with "children" being particularly prominent throughout the literatures. "risk factors" and "plastic bronchitis" may represent emerging hotspots in MPP research. Antibiotic therapy, herpes simplex virus infections, and serology detection were the high interest surrounding topics over past decade. mNGS, severe community-acquired pneumonia, co-infections of adenovirus or RSV may become focal points in future. CRP and IL-17 A represented significant genes among MP infection. Positive regulation of cytokine production played a critical role in MP infection.
CONCLUSION: This bibliometric analysis provides insights into its status, frontiers, and hotspots, offering essential guidance to address challenges in MP.

Keywords

Bibliometric analysis Co-infection Community-acquired pneumonia IL-17A Mycoplasma pneumoniae

References

  1. Waites KB, Xiao L, Liu Y, Balish MF, Atkinson TP. Mycoplasma pneumoniae from the respiratory tract and Beyond. Clin Microbiol Rev. 2017;30(3):747���809. https://doi.org/10.1128/CMR.00114-16 . [DOI: 10.1128/CMR.00114-16]
  2. Borchsenius SN, Daks A, Fedorova O, Chernova O, Barlev NA. Effects of mycoplasma infection on the host organism response via p53/NF-kappaB signaling. J Cell Physiol. 2018;234(1):171���80. https://doi.org/10.1002/jcp.26781 . [DOI: 10.1002/jcp.26781]
  3. Chen B, Gao Ly C, Qj Z, Td, Tong Y, Han N, et al. The epidemic characteristics of Mycoplasma pneumoniae infection among children in Anhui, China, 2015���2023. Microbiol Spectr. 2024;12(10):e0065124. https://doi.org/10.1128/spectrum.00651-24 . [DOI: 10.1128/spectrum.00651-24]
  4. Infections GBDLR, Antimicrobial Resistance C. Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990���2021: a systematic analysis from the global burden of Disease Study 2021. Lancet Infect Dis. 2024;24(9):974���1002. https://doi.org/10.1016/S1473-3099(24)00176-2 . [DOI: 10.1016/S1473-3099(24)00176-2]
  5. Wu X, Chen R, Mo D, Wang Y, Xia Y, He M. Analysis of Mycoplasma pneumoniae pneumonia and viral coinfection in southern Guangzhou after the COVID-19 pandemic. J Thorac Disease. 2024;16(10):6789���98. https://doi.org/10.21037/jtd-24-729 . [DOI: 10.21037/jtd-24-729]
  6. Li ZJ, Zhang HY, Ren LL, Lu QB, Ren X, Zhang CH, et al. Etiological and epidemiological features of acute respiratory infections in China. Nat Commun. 2021;12(1):5026. https://doi.org/10.1038/s41467-021-25120-6 . [DOI: 10.1038/s41467-021-25120-6]
  7. Kim K, Jung S, Kim M, Park S, Yang HJ, Lee E. Global trends in the proportion of Macrolide-Resistant Mycoplasma pneumoniae infections: a systematic review and Meta-analysis. JAMA Netw open. 2022;5(7):e2220949. https://doi.org/10.1001/jamanetworkopen.2022.20949 . [DOI: 10.1001/jamanetworkopen.2022.20949]
  8. Chen YC, Hsu WY, Chang TH. Macrolide-resistant Mycoplasma pneumoniae infections in Pediatric Community-Acquired Pneumonia. Emerg Infect Dis. 2020;26(7):1382���91. https://doi.org/10.3201/eid2607.200017 . [DOI: 10.3201/eid2607.200017]
  9. Yang S, Lu S, Guo Y, Luan W, Liu J, Wang L. A comparative study of general and severe mycoplasma pneumoniae pneumonia in children. BMC Infect Dis. 2024;24(1):449. https://doi.org/10.1186/s12879-024-09340-x . [DOI: 10.1186/s12879-024-09340-x]
  10. Ding G, Zhang X, Vinturache A, van Rossum AMC, Yin Y, Zhang Y. Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia. Eur J Pediatrics. 2024;183(7):3001���11. https://doi.org/10.1007/s00431-024-05519-1 . [DOI: 10.1007/s00431-024-05519-1]
  11. Cao B, Qu JX, Yin YD, Eldere JV. Overview of antimicrobial options for Mycoplasma pneumoniae pneumonia: focus on macrolide resistance. Clin Respir J. 2017;11(4):419���29. https://doi.org/10.1111/crj.12379 . [DOI: 10.1111/crj.12379]
  12. Young L, Sung J, Stacey G, Masters JR. Detection of Mycoplasma in cell cultures. Nat Protoc. 2010;5(5):929���34. https://doi.org/10.1038/nprot.2010.43 . [DOI: 10.1038/nprot.2010.43]
  13. Loens K, Ieven M. Mycoplasma pneumoniae: current knowledge on nucleic acid amplification techniques and Serological Diagnostics. Front Microbiol. 2016;7:448. https://doi.org/10.3389/fmicb.2016.00448 . [DOI: 10.3389/fmicb.2016.00448]
  14. Leng M, Yang J, Zhou J. The molecular characteristics, diagnosis, and treatment of macrolide-resistant Mycoplasma pneumoniae in children. Front Pead. 2023;11:1115009. https://doi.org/10.3389/fped.2023.1115009 . [DOI: 10.3389/fped.2023.1115009]
  15. Gao L, Sun Y. Laboratory diagnosis and treatment of Mycoplasma pneumoniae infection in children: a review. Ann Med. 2024;56(1):2386636. https://doi.org/10.1080/07853890.2024.2386636 . [DOI: 10.1080/07853890.2024.2386636]
  16. Zhang Y, Liu M, Wang J, Han K, Han F, Wang B, et al. Bibliometric analysis of the association between drinking water pollution and bladder cancer. Front Oncol. 2023;13:1170700. https://doi.org/10.3389/fonc.2023.1170700 . [DOI: 10.3389/fonc.2023.1170700]
  17. Song Z, Jia G, Luo G, Han C, Zhang B, Wang X. Global research trends of Mycoplasma pneumoniae pneumonia in children: a bibliometric analysis. Front Pead. 2023;11:1306234. https://doi.org/10.3389/fped.2023.1306234 . [DOI: 10.3389/fped.2023.1306234]
  18. Liu C, Wang R, Ge S, Wang B, Li S, Yan B. Research status and challenges of Mycoplasma pneumoniae pneumonia in children: a bibliometric and visualization analysis from 2011 to 2023. Medicine. 2024;103(11):e37521. https://doi.org/10.1097/MD.0000000000037521 . [DOI: 10.1097/MD.0000000000037521]
  19. Cao S, Wei Y, Huang J, Yue Y, Deng A, Zeng H, et al. A bibliometric worldview of breast-conserving surgery for breast cancer from 2013 to 2023. Front Oncol. 2024;14:1405351. https://doi.org/10.3389/fonc.2024.1405351 . [DOI: 10.3389/fonc.2024.1405351]
  20. Zhou Y, Wu T, Sun J, Bi H, Xiao Y, Wang H. Mapping the landscape and exploring trends in macrophage-related research within non-small cell lung cancer: a comprehensive bibliometric analysis. Front Immunol. 2024;15:1398166. https://doi.org/10.3389/fimmu.2024.1398166 . [DOI: 10.3389/fimmu.2024.1398166]
  21. Wang JH, Pan GR, Jiang L. A bibliometric analysis of immunotherapy for atherosclerosis: trends and hotspots prediction. Front Immunol. 2024;15:1493250. https://doi.org/10.3389/fimmu.2024.1493250 . [DOI: 10.3389/fimmu.2024.1493250]
  22. J. F. Compound Annual Growth Rate (CAGR). November 12, 2024 https://www.investopedia.com/terms/c/cagr.asp. ; 2024.
  23. Meyer Sauteur PM, Beeton ML, European Society of Clinical M, Infectious Diseases Study Group for M, Chlamydia I, the EMpSsg. Mycoplasma pneumoniae: delayed re-emergence after COVID-19 pandemic restrictions. Lancet Microbe. 2024;5(2):e100���1. https://doi.org/10.1016/S2666-5247(23)00344-0 . [DOI: 10.1016/S2666-5247(23)00344-0]
  24. Perez-Lazo G, Silva-Caso W, Del Valle-Mendoza J, Morales-Moreno A, Ballena-Lopez J, Soto-Febres F, et al. Identification of coinfections by viral and bacterial pathogens in COVID-19 hospitalized patients in Peru: molecular diagnosis and clinical characteristics. Antibiotics. 2021;10(11). https://doi.org/10.3390/antibiotics10111358 .
  25. Prevention USCfDCa. Pneumoniae Infections Have Been Increasing. (2024). Accessed October 18, 12:00 PM EDT 2024.
  26. Diaz MH, Winchell JM. The evolution of Advanced Molecular Diagnostics for the detection and characterization of Mycoplasma pneumoniae. Front Microbiol. 2016;7:232. https://doi.org/10.3389/fmicb.2016.00232 . [DOI: 10.3389/fmicb.2016.00232]
  27. Wu Q, Martin RJ, Lafasto S, Efaw BJ, Rino JG, Harbeck RJ, et al. Toll-like receptor 2 down-regulation in established mouse allergic lungs contributes to decreased mycoplasma clearance. Am J Respir Crit Care Med. 2008;177(7):720���9. https://doi.org/10.1164/rccm.200709-1387OC . [DOI: 10.1164/rccm.200709-1387OC]
  28. Weber M, Sogues A, Yus E, Burgos R, Gallo C, Martinez S, et al. Comprehensive quantitative modeling of translation efficiency in a genome-reduced bacterium. Mol Syst Biol. 2023;19(10):e11301. https://doi.org/10.15252/msb.202211301 . [DOI: 10.15252/msb.202211301]
  29. Jin P, Han C, Guo W, Xu Y. Mycoplasma pneumoniae pneumonia-associated thromboembolism with plastic bronchitis: a series of five case reports and literature review. Ital J Pediatr. 2024;50(1):117. https://doi.org/10.1186/s13052-024-01690-1 . [DOI: 10.1186/s13052-024-01690-1]
  30. Tsai TA, Tsai CK, Kuo KC, Yu HR. Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children. Journal of microbiology, immunology, and infection���=���Wei Mian Yu Gan ran Za Zhi. 2021;54(4):557���65. https://doi.org/10.1016/j.jmii.2020.10.002
  31. Zhang C, Li Z, Wang M, Zhou J, Yu W, Liu H, et al. High specificity of metagenomic next-generation sequencing using protected bronchial brushing sample in diagnosing pneumonia in children. Front Cell Infect Microbiol. 2023;13:1165432. https://doi.org/10.3389/fcimb.2023.1165432 . [DOI: 10.3389/fcimb.2023.1165432]
  32. Jiang S, Liu Y, Zheng H, Zhang L, Zhao H, Sang X, et al. Evolutionary patterns and research frontiers in neoadjuvant immunotherapy: a bibliometric analysis. Int J Surg. 2023;109(9):2774���83. https://doi.org/10.1097/JS9.0000000000000492 . [DOI: 10.1097/JS9.0000000000000492]
  33. Chen M, Deng H, Zhao Y, Miao X, Gu H, Bi Y, et al. Toll-like receptor 2 modulates pulmonary inflammation and TNF-alpha release mediated by Mycoplasma pneumoniae. Front Cell Infect Microbiol. 2022;12:824027. https://doi.org/10.3389/fcimb.2022.824027 . [DOI: 10.3389/fcimb.2022.824027]
  34. Chauffard A, Bridevaux PO, Carballo S, Prendki V, Reny JL, Stirnemann J, et al. Accuracy of a score predicting the presence of an atypical pathogen in hospitalized patients with moderately severe community-acquired pneumonia. BMC Infect Dis. 2022;22(1):424. https://doi.org/10.1186/s12879-022-07423-1 . [DOI: 10.1186/s12879-022-07423-1]
  35. Li Y, Yu J, Wang Y, Yi J, Guo L, Wang Q, et al. Cocirculation and coinfection of multiple respiratory viruses during autumn and winter seasons of 2023 in Beijing, China: a retrospective study. J Med Virol. 2024;96(4):e29602. https://doi.org/10.1002/jmv.29602 . [DOI: 10.1002/jmv.29602]
  36. Xu Y, Yang C, Sun P, Zeng F, Wang Q, Wu J, et al. Epidemic features and megagenomic analysis of childhood Mycoplasma pneumoniae post COVID-19 pandemic: a 6-year study in southern China. Emerg Microbes Infections. 2024;13(1):2353298. https://doi.org/10.1080/22221751.2024.2353298 . [DOI: 10.1080/22221751.2024.2353298]
  37. Hu J, Ye Y, Chen X, Xiong L, Xie W, Liu P. Insight into the pathogenic mechanism of Mycoplasma pneumoniae. Curr Microbiol. 2022;80(1):14. https://doi.org/10.1007/s00284-022-03103-0 . [DOI: 10.1007/s00284-022-03103-0]
  38. Fan H, Lu B, Yang D, Zhang D, Shi T, Lu G. Distribution and expression of IL-17 and related cytokines in children with Mycoplasma pneumoniae Pneumonia. Jpn J Infect Dis. 2019;72(6):387���93. https://doi.org/10.7883/yoken.JJID.2019.113 . [DOI: 10.7883/yoken.JJID.2019.113]
  39. Yang M, Meng F, Wang K, Gao M, Lu R, Li M, et al. Interleukin 17A as a good predictor of the severity of Mycoplasma pneumoniae pneumonia in children. Sci Rep. 2017;7(1):12934. https://doi.org/10.1038/s41598-017-13292-5 . [DOI: 10.1038/s41598-017-13292-5]
  40. Leerach N, Sitthisak S, Kitti T, Teerawattanapong N, Mahikul W, Lamlertthon S, et al. Association of serum interleukin-17 level and Mycoplasma pneumoniae pneumonia in children: a systematic review and meta-analysis. Translational Pediatr. 2024;13(9):1588���99. https://doi.org/10.21037/tp-24-218 . [DOI: 10.21037/tp-24-218]

Grants

  1. 2024AFB968/Natural Science Foundation of Hubei Municipal Health Commission
  2. 82202536/National Natural Science Foundation of China
Journal Article

Word Cloud

Created with Highcharts 10.0.0pneumoniapneumoniaeinfectionresearchMPanalysisusingarticlesBibliometrickeywordsgenesinterestMPPChinaUSAhighestmayhotspotsbibliometricMycoplasmaPURPOSE:SevererefractoryextrapulmonarycomplicationscausedmycoplasmaincreasingposingseriousthreathealthstudyaimedexplorebreakthroughinvestigationsfurtherMETHODS:WebScienceCoreCollectionqueriedsearchtermTS="mycoplasmapneumoniae"January12009September242024indicatorsanalyzedVOSviewerPajekScimagoGraphicaCiteSpaceutilizedvisualanalysesincludingcontributionsdifferentcountries/regionsinstitutionsauthorshippatternsjournalsco-citationsRESULTS:3093collectedshowedincreaseprolificcontributordemonstratedstrongestcollaborationwillingnesscooperationfrequencyclosestrelationshipUKsingle-articlecitationcountFudanUniversitygreatesttotallinkstrengthtop"MycoplasmaPneumoniae""community-acquiredpneumonia""children"particularlyprominentthroughoutliteratures"riskfactors""plasticbronchitis"representemergingAntibiotictherapyherpessimplexvirusinfectionsserologydetectionhighsurroundingtopicspastdecademNGSseverecommunity-acquiredco-infectionsadenovirusRSVbecomefocalpointsfutureCRPIL-17 ArepresentedsignificantamongPositiveregulationcytokineproductionplayedcriticalroleCONCLUSION:providesinsightsstatusfrontiersofferingessentialguidanceaddresschallengesPanoramicquantitativevisualization-basedCo-infectionCommunity-acquiredIL-17A

Similar Articles

Cited By