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Asian journal of pharmaceutical sciences
Feb, 2025;20 (1): 101007.

Electrically conductive "SMART" hydrogels for on-demand drug delivery.

Soumajyoti Ghosh, Nikhil Kumar, Santanu Chattopadhyay
Author Information
  1. Soumajyoti Ghosh: Rubber Technology Centre, Indian Institute of Technology, Kharagpur 721302, India.
  2. Nikhil Kumar: Advanced Technology Development Centre, Indian Institute of Technology, Kharagpur 721302, India.
  3. Santanu Chattopadhyay: Rubber Technology Centre, Indian Institute of Technology, Kharagpur 721302, India.
PMID: 39935975 DOI: 10.1016/j.ajps.2024.101007

Abstract

In the current transformative era of biomedicine, hydrogels have established their presence in biomaterials due to their superior biocompatibility, tuneability and resemblance with native tissue. However, hydrogels typically exhibit poor conductivity due to their hydrophilic polymer structure. Electrical conductivity provides an important enhancement to the properties of hydrogel-based systems in various biomedical applications such as drug delivery and tissue engineering. Consequently, researchers are developing combinatorial strategies to develop electrically responsive "SMART" systems to improve the therapeutic efficacy of biomolecules. Electrically conductive hydrogels have been explored for various drug delivery applications, enabling higher loading of therapeutic cargo with on-demand delivery. This review emphasizes the properties, mechanisms, fabrication techniques and recent advancements of electrically responsive "SMART" systems aiding on-site drug delivery applications. Additionally, it covers prospects for the successful translation of these systems into clinical research.

Keywords

Conductive polymers Electrically conductive hydrogels Hydrogels On-demand drug delivery

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Word Cloud

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