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International journal of molecular sciences
Jan 27, 2025;26 (3):

From Cell Architecture to Mitochondrial Signaling: Role of Intermediate Filaments in Health, Aging, and Disease.

Emanuele Marzetti, Rosa Di Lorenzo, Riccardo Calvani, Vito Pesce, Francesco Landi, Hélio José Coelho-Júnior, Anna Picca
Author Information
  1. Emanuele Marzetti: Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy. ORCID
  2. Rosa Di Lorenzo: Department of Biosciences, Biotechnologies and Environment, Università degli Studi di Bari Aldo Moro, Via Edoardo Orabona 4, 70125 Bari, Italy. ORCID
  3. Riccardo Calvani: Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy. ORCID
  4. Vito Pesce: Department of Biosciences, Biotechnologies and Environment, Università degli Studi di Bari Aldo Moro, Via Edoardo Orabona 4, 70125 Bari, Italy. ORCID
  5. Francesco Landi: Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy.
  6. Hélio José Coelho-Júnior: Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy. ORCID
  7. Anna Picca: Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy. ORCID
PMID: 39940869 DOI: 10.3390/ijms26031100

Abstract

The coordination of cytoskeletal proteins shapes cell architectures and functions. Age-related changes in cellular mechanical properties have been linked to decreased cellular and tissue dysfunction. Studies have also found a relationship between mitochondrial function and the cytoskeleton. Cytoskeleton inhibitors impact mitochondrial quality and function, including motility and morphology, membrane potential, and respiration. The regulatory properties of the cytoskeleton on mitochondrial functions are involved in the pathogenesis of several diseases. Disassembly of the axon's cytoskeleton and the release of neurofilament fragments have been documented during neurodegeneration. However, these changes can also be related to mitochondrial impairments, spanning from reduced mitochondrial quality to altered bioenergetics. Herein, we discuss recent research highlighting some of the pathophysiological roles of cytoskeleton disassembly in aging, neurodegeneration, and neuromuscular diseases, with a focus on studies that explored the relationship between intermediate filaments and mitochondrial signaling as relevant contributors to cellular health and disease.

Keywords

axonal transport cell architecture cell quality cytoskeleton mitochondrial quality muscle aging neurodegeneration neurofilaments sarcomere vimentin

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MeSH Term

Humans
Mitochondria
Aging
Intermediate Filaments
Animals
Signal Transduction
Cytoskeleton
Neurodegenerative Diseases
Journal Article Review

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