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International journal of yoga
2024 Sep-Dec;17 (3): 163-174.

Yoga Therapy Attenuates the Progression of Diabetes - Insights from Proteomics and Metabolomics Analysis.

Babasaheb P Sonwane, Pooja Raut, Jyotsna Chitalkar, Smita Godbole, Shanta Sabnis, Jyoti Gupta, B Santhakumari, Mukund V Deshpande, Mahesh J Kulkarni
Author Information
  1. Babasaheb P Sonwane: Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, Maharashtra, India.
  2. Pooja Raut: Medical Centre, CSIR-National Chemical Laboratory, Pune, Maharashtra, India.
  3. Jyotsna Chitalkar: Medical Centre, CSIR-National Chemical Laboratory, Pune, Maharashtra, India.
  4. Smita Godbole: Medical Centre, CSIR-National Chemical Laboratory, Pune, Maharashtra, India.
  5. Shanta Sabnis: Medical Centre, CSIR-National Chemical Laboratory, Pune, Maharashtra, India.
  6. Jyoti Gupta: Medical Centre, CSIR-National Chemical Laboratory, Pune, Maharashtra, India.
  7. B Santhakumari: Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, Maharashtra, India.
  8. Mukund V Deshpande: Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, Maharashtra, India.
  9. Mahesh J Kulkarni: Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, Maharashtra, India.
PMID: 39959515 DOI: 10.4103/ijoy.ijoy_178_24

Abstract

Objective: Diabetes management remains challenging despite advancements in therapeutics, with many subjects developing complications. Yoga has been shown to aid diabetes management. This study investigates the impact of yoga therapy on diabetes progression, utilizing proteomics and metabolomics analyses to explore underlying molecular mechanisms.
Methodology: A 3-month longitudinal study involving healthy subjects with prediabetes and diabetes was conducted. Blood glucose, glycated hemoglobin (HbA1c), lipid profile, and malondialdehyde (MDA) levels were measured before and after the yoga intervention.
Results and Conclusion: Healthy subjects showed no significant changes in blood glucose, lipid profile, HbA1c, or MDA levels. However, subjects with prediabetes and diabetes experienced positive changes, with decreases in HbA1c and MDA levels. Proteomics and metabolomics analyses provided insights into the molecular mechanisms by which yoga attenuates diabetes progression in subjects with prediabetes and diabetes. This study is a pioneering effort to understand the molecular basis of yoga's beneficial effects on diabetes management.

Keywords

Diabetes glycated hemoglobin metabolomics proteomics yoga

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Journal Article

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