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Feb 04, 2025;

rTCT: Rodent Triangle Completion Task to facilitate translational study of path integration.

Stephen Duncan, Sulaiman Rehman, Vladislava Sagen, Irene Choi, Sami Lawrence, Om Kalani, Lisette Gold, Lillian Goldman, Sophia Ramlo, Kylene Stickel, Dylan Layfield, Thomas Wolbers, Zoran Tiganj, Ehren L Newman
Author Information
  1. Stephen Duncan: Department of Psychology & Brain Sciences, Indiana University; 1101 E. 10 Street, Bloomington, IN, 47405, U.S.A.
  2. Sulaiman Rehman: Department of Psychology & Brain Sciences, Indiana University; 1101 E. 10 Street, Bloomington, IN, 47405, U.S.A.
  3. Vladislava Sagen: German Center for Neurodegenerative Diseases (DZNE), 39120, Magdeburg, Germany.
  4. Irene Choi: Department of Psychology & Brain Sciences, Indiana University; 1101 E. 10 Street, Bloomington, IN, 47405, U.S.A.
  5. Sami Lawrence: Department of Psychology & Brain Sciences, Indiana University; 1101 E. 10 Street, Bloomington, IN, 47405, U.S.A.
  6. Om Kalani: Department of Psychology & Brain Sciences, Indiana University; 1101 E. 10 Street, Bloomington, IN, 47405, U.S.A.
  7. Lisette Gold: Department of Psychology & Brain Sciences, Indiana University; 1101 E. 10 Street, Bloomington, IN, 47405, U.S.A.
  8. Lillian Goldman: Department of Psychology & Brain Sciences, Indiana University; 1101 E. 10 Street, Bloomington, IN, 47405, U.S.A.
  9. Sophia Ramlo: Department of Psychology & Brain Sciences, Indiana University; 1101 E. 10 Street, Bloomington, IN, 47405, U.S.A.
  10. Kylene Stickel: Department of Psychology & Brain Sciences, Indiana University; 1101 E. 10 Street, Bloomington, IN, 47405, U.S.A.
  11. Dylan Layfield: Department of Psychology & Brain Sciences, Indiana University; 1101 E. 10 Street, Bloomington, IN, 47405, U.S.A.
  12. Thomas Wolbers: German Center for Neurodegenerative Diseases (DZNE), 39120, Magdeburg, Germany.
  13. Zoran Tiganj: Department of Psychology & Brain Sciences, Indiana University; 1101 E. 10 Street, Bloomington, IN, 47405, U.S.A.
  14. Ehren L Newman: Department of Psychology & Brain Sciences, Indiana University; 1101 E. 10 Street, Bloomington, IN, 47405, U.S.A. ORCID
PMID: 39975325 DOI: 10.1101/2025.02.04.636463

Abstract

Path integration is navigation in the absence of environmental landmarks and is a primary cognitive mechanism underlying spatial memory. Path integration performance is primarily assessed in humans using the Triangle Completion Task (TCT). In humans, TCT has shown promise for the early diagnosis of Alzheimer's disease. In rodents, however, path integration is assessed using a wide variety of tasks but none of which currently provide a homologue for the TCT. As rodents are routinely used as preclinical models, homologous path integration tasks that result in comparable performance metrics between species are important. In the present study we developed and tested a novel rodent version of the triangle completion task to enhance cross species comparability of path integration performance. Rats were able to comprehend and perform the task. A group of Alzheimer's disease model rats (TgF344-AD) exhibited similar path integration performance to their wild-type littermates; however, analysis of behavioural structure suggests use of differing behavioural strategies. This work establishes a novel rodent homologue of the triangle completion task, facilitating enhanced reverse translational study of human path integration.

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Grants

  1. R01 AG076198/NIA NIH HHS
Journal Article Preprint
Article has an altmetric score of 3

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