OpenLB
Open Library of Bioscience
Advanced Search
Marine drugs
Feb 17, 2025;23 (2):

Marine Phytoplankton Bioactive Lipids and Their Perspectives in Clinical Inflammation.

Edoardo Andrea Cutolo, Rosanna Campitiello, Valeria Di Dato, Ida Orefice, Max Angstenberger, Maurizio Cutolo
Author Information
  1. Edoardo Andrea Cutolo: Laboratory of Photosynthesis and Bioenergy, Department of Biotechnology, University of Verona, Strada le Grazie 15, 37134 Verona, Italy. ORCID
  2. Rosanna Campitiello: Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, 16132 Genova, Italy. ORCID
  3. Valeria Di Dato: Stazione Zoologica Anton Dohrn Napoli, Ecosustainable Marine Biotechnology Department, Via Ammiraglio Ferdinando Acton 55, 80133 Napoli, Italy. ORCID
  4. Ida Orefice: Stazione Zoologica Anton Dohrn Napoli, Ecosustainable Marine Biotechnology Department, Via Ammiraglio Ferdinando Acton 55, 80133 Napoli, Italy. ORCID
  5. Max Angstenberger: Institute of Molecular Biosciences, Goethe University Frankfurt am Main, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany. ORCID
  6. Maurizio Cutolo: Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, 16132 Genova, Italy. ORCID
PMID: 39997210 DOI: 10.3390/md23020086

Abstract

Marine phytoplankton is an emerging source of immunomodulatory bioactive lipids (BLs). Under physiological growth conditions and upon stress challenges, several eukaryotic microalgal species accumulate lipid metabolites that resemble the precursors of animal mediators of inflammation: eicosanoids and prostaglandins. Therefore, marine phytoplankton could serve as a biotechnological platform to produce functional BLs with therapeutic applications in the management of chronic inflammatory diseases and other clinical conditions. However, to be commercially competitive, the lipidic precursor yields should be enhanced. Beside tailoring the cultivation of native producers, genetic engineering is a feasible strategy to accrue the production of lipid metabolites and to introduce heterologous biosynthetic pathways in microalgal hosts. Here, we present the state-of-the-art clinical research on immunomodulatory lipids from eukaryotic marine phytoplankton and discuss synthetic biology approaches to boost their light-driven biosynthesis.

Keywords

bioactive lipids diatoms eicosanoids inflammation microalgae

References

  1. Essays Biochem. 2020 Sep 23;64(3):463-484 [PMID: 32602531]
  2. Foods. 2023 Dec 29;13(1): [PMID: 38201152]
  3. Pharmacol Res. 2013 Apr;70(1):50-9 [PMID: 23298698]
  4. Physiol Plant. 2021 Oct;173(2):603-611 [PMID: 34076276]
  5. J Agric Food Chem. 2024 Jul 31;72(30):16749-16760 [PMID: 39016675]
  6. Prostaglandins Other Lipid Mediat. 2004 Jan;73(1-2):47-50 [PMID: 15165030]
  7. Nature. 2025 Jan;637(8046):691-697 [PMID: 39695224]
  8. J Biol Chem. 2003 Jun 27;278(26):23317-23 [PMID: 12682047]
  9. Appl Microbiol Biotechnol. 2018 May;102(10):4255-4267 [PMID: 29574616]
  10. ACS Synth Biol. 2018 Feb 16;7(2):328-338 [PMID: 29298053]
  11. Microb Cell Fact. 2024 Nov 29;23(1):322 [PMID: 39609835]
  12. Biochim Biophys Acta. 2016 Mar;1861(3):239-48 [PMID: 26747649]
  13. Sci Rep. 2020 Mar 25;10(1):5374 [PMID: 32214130]
  14. Biotechnol Biofuels. 2015 Sep 25;8:161 [PMID: 26413160]
  15. J Genet Eng Biotechnol. 2024 Dec;22(4):100407 [PMID: 39674656]
  16. Mar Drugs. 2022 Jun 28;20(7): [PMID: 35877717]
  17. Gastroenterology. 2018 Feb;154(3):500-514 [PMID: 29221664]
  18. Int J Mol Sci. 2020 Apr 27;21(9): [PMID: 32349258]
  19. Biotechnol Lett. 2014 Nov;36(11):2193-8 [PMID: 25048234]
  20. Transgenic Res. 2013 Oct;22(5):905-11 [PMID: 23463075]
  21. Free Radic Biol Med. 2017 Jan;102:229-239 [PMID: 27932075]
  22. Prog Lipid Res. 2018 Apr;70:1-16 [PMID: 29524459]
  23. Phytochem Rev. 2022 Jan 23;:1-28 [PMID: 35095355]
  24. ACS Synth Biol. 2024 Jul 19;13(7):2150-2165 [PMID: 38986010]
  25. Mar Drugs. 2022 Apr 24;20(5): [PMID: 35621936]
  26. Mol Biol Rep. 2020 Jun;47(6):4569-4586 [PMID: 32430846]
  27. Plant J. 2025 Jan;121(2):e17227 [PMID: 39868466]
  28. Biochim Biophys Acta. 2004 Nov 8;1686(1-2):100-7 [PMID: 15522826]
  29. Biol Direct. 2024 Nov 11;19(1):108 [PMID: 39529073]
  30. Cell Rep. 2022 Jun 7;39(10):110914 [PMID: 35675777]
  31. Br J Ophthalmol. 2021 Jun;105(Suppl 1):1-169 [PMID: 34675001]
  32. Plant Cell. 2020 Mar;32(3):547-572 [PMID: 31852772]
  33. EClinicalMedicine. 2023 Sep 09;64:102193 [PMID: 37731935]
  34. Bioresour Bioprocess. 2022 Dec 19;9(1):130 [PMID: 38647795]
  35. Am J Obstet Gynecol. 2024 Mar;230(3S):S669-S695 [PMID: 38462252]
  36. J Leukoc Biol. 2015 Jun;97(6):1049-70 [PMID: 25877930]
  37. Biomed Res Int. 2015;2015:690692 [PMID: 25861641]
  38. Biotechnol Biofuels. 2020 Mar 05;13:38 [PMID: 32158502]
  39. Reprod Sci. 2010 Mar;17(3):209-18 [PMID: 20065301]
  40. Mar Drugs. 2022 Mar 02;20(3): [PMID: 35323486]
  41. Org Biomol Chem. 2017 Aug 2;15(30):6281-6301 [PMID: 28737187]
  42. Science. 2001 Nov 30;294(5548):1871-5 [PMID: 11729303]
  43. ACS Synth Biol. 2020 Oct 16;9(10):2840-2850 [PMID: 32916053]
  44. Front Plant Sci. 2022 Jan 04;12:784780 [PMID: 35058949]
  45. Prog Lipid Res. 2025 Jan;97:101320 [PMID: 39793901]
  46. J Pharm Bioallied Sci. 2016 Apr-Jun;8(2):83-91 [PMID: 27134458]
  47. Nutrients. 2022 Mar 28;14(7): [PMID: 35406026]
  48. Front Immunol. 2018 Jan 29;9:38 [PMID: 29434586]
  49. Biomolecules. 2020 May 21;10(5): [PMID: 32455747]
  50. J Lab Clin Med. 1996 Jul;128(1):27-38 [PMID: 8759934]
  51. Arterioscler Thromb Vasc Biol. 2011 May;31(5):986-1000 [PMID: 21508345]
  52. AMB Express. 2018 Mar 30;8(1):50 [PMID: 29603024]
  53. ACS Synth Biol. 2021 Dec 17;10(12):3369-3378 [PMID: 34793143]
  54. Commun Biol. 2022 Jan 11;5(1):19 [PMID: 35017659]
  55. Nat Med. 1999 Jun;5(6):698-701 [PMID: 10371510]
  56. JAMA. 2001 Aug 22-29;286(8):954-9 [PMID: 11509060]
  57. J Physiol. 1936 Nov 6;88(2):213-34 [PMID: 16994817]
  58. Plant Biotechnol J. 2018 Jan;16(1):298-309 [PMID: 28605577]
  59. New Phytol. 2019 Feb;221(3):1317-1327 [PMID: 30306559]
  60. Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:95-114 [PMID: 12432912]
  61. Pharmacol Ther. 2004 Aug;103(2):147-66 [PMID: 15369681]
  62. Biochem Biophys Res Commun. 1984 Apr 16;120(1):278-85 [PMID: 6424676]
  63. Nat Prod Res. 2013;27(12):1084-90 [PMID: 22973805]
  64. Int J Mol Sci. 2021 Sep 11;22(18): [PMID: 34576003]
  65. Foods. 2023 Nov 10;12(22): [PMID: 38002136]
  66. Metab Eng. 2021 Jul;66:239-258 [PMID: 33971293]
  67. J Clin Invest. 2001 Jul;108(1):15-23 [PMID: 11435451]
  68. Mar Drugs. 2023 Feb 22;21(3): [PMID: 36976185]
  69. Stem Cell Res Ther. 2024 Nov 4;15(1):394 [PMID: 39497203]
  70. Biotechnol Adv. 2021 Nov 15;52:107836 [PMID: 34534633]
  71. Microb Biotechnol. 2024 Dec;17(12):e70069 [PMID: 39688456]
  72. Food Chem X. 2024 Jul 26;23:101697 [PMID: 39176040]
  73. J Am Coll Nutr. 2002 Dec;21(6):495-505 [PMID: 12480795]
  74. Br J Pharmacol. 2008 Feb;153(3):410-9 [PMID: 17721551]
  75. Angew Chem Int Ed Engl. 2008;47(32):5894-955 [PMID: 18649300]
  76. Mol Biotechnol. 2024 Sep 13;: [PMID: 39271617]
  77. Nutrients. 2020 Sep 22;12(9): [PMID: 32971852]
  78. Mar Drugs. 2024 Jan 24;22(2): [PMID: 38393025]
  79. Mol Nutr Food Res. 2014 Mar;58(3):580-90 [PMID: 24311515]
  80. Front Plant Sci. 2019 Nov 29;10:1573 [PMID: 31850043]
  81. PLoS One. 2012;7(3):e33329 [PMID: 22442685]
  82. Clin Immunol. 2006 Jun;119(3):229-40 [PMID: 16540375]
  83. Phytochemistry. 2016 Apr;124:68-78 [PMID: 26895707]
  84. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2214119120 [PMID: 37307488]
  85. Pharmacol Res. 2021 Apr;166:105479 [PMID: 33549728]
  86. Annu Rev Biochem. 2000;69:145-82 [PMID: 10966456]
  87. Plant J. 2015 Jan;81(1):147-59 [PMID: 25267488]
  88. Nat Commun. 2024 Nov 1;15(1):9464 [PMID: 39487111]
  89. Curr Opin Biotechnol. 2024 Jun;87:103130 [PMID: 38579630]
  90. Mar Drugs. 2024 Jun 28;22(7): [PMID: 39057413]
  91. Sci Rep. 2019 Jul 9;9(1):9893 [PMID: 31289324]
  92. Trends Plant Sci. 2021 Nov;26(11):1199-1200 [PMID: 34226108]
  93. Sci Rep. 2019 Apr 2;9(1):5391 [PMID: 30940823]
  94. Mar Drugs. 2023 Dec 07;21(12): [PMID: 38132951]
  95. Br J Nutr. 2024 Oct 14;132(7):898-918 [PMID: 39411832]
  96. Sci Rep. 2016 Apr 25;6:24951 [PMID: 27108533]
  97. Cells. 2022 Apr 21;11(9): [PMID: 35563717]
  98. Curr Diabetes Rev. 2007 Aug;3(3):198-203 [PMID: 18220672]
  99. Prostaglandins Other Lipid Mediat. 2017 Nov;133:111-122 [PMID: 28610769]
  100. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):434-9 [PMID: 26712011]
  101. J Biol Chem. 2005 Nov 11;280(45):37301-9 [PMID: 16135509]
  102. J Phycol. 2011 Oct;47(5):1050-6 [PMID: 27020186]
  103. Trends Immunol. 2023 Mar;44(3):162-171 [PMID: 36707339]
  104. Ann Nutr Metab. 1994;38(2):85-96 [PMID: 8067689]
  105. Nutrients. 2020 Jun 23;12(6): [PMID: 32585854]
  106. Clin Nutr ESPEN. 2024 Oct;63:240-258 [PMID: 38980796]
  107. Indian J Ophthalmol. 2023 May;71(5):1768-1776 [PMID: 37203029]
  108. Plant Physiol. 2024 Jan 31;194(2):958-981 [PMID: 37801606]
  109. New Phytol. 2024 Nov;244(4):1467-1481 [PMID: 39253772]
  110. Nat Commun. 2014 May 29;5:3831 [PMID: 24871200]
  111. Appl Microbiol Biotechnol. 2024 Jun 11;108(1):368 [PMID: 38860989]
  112. Plant Methods. 2016 Nov 24;12:49 [PMID: 27904648]
  113. Appl Microbiol Biotechnol. 2011 Aug;91(4):905-15 [PMID: 21720821]
  114. Plant Physiol. 2024 Oct 1;196(2):1356-1373 [PMID: 38796833]
  115. Int J Mol Sci. 2016 Jan 14;17(1): [PMID: 26784174]
  116. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2806-8 [PMID: 26933215]
  117. J Phys Chem A. 2020 Jun 25;124(25):5081-5088 [PMID: 32482065]
  118. Mar Drugs. 2015 Aug 20;13(8):5402-24 [PMID: 26308008]
  119. Biology (Basel). 2021 Mar 26;10(4): [PMID: 33810286]
  120. J Lipid Res. 2009 Apr;50 Suppl:S29-34 [PMID: 18952571]
  121. Curr Opin Clin Nutr Metab Care. 2015 Mar;18(2):147-54 [PMID: 25635599]
  122. PLoS Biol. 2014 Jun 24;12(6):e1001889 [PMID: 24959919]
  123. FEBS Lett. 2020 Jun;594(11):1797-1808 [PMID: 32215916]
  124. Biochim Biophys Acta. 2015 Apr;1851(4):414-21 [PMID: 25038274]
  125. Mar Drugs. 2016 Mar 09;14(3): [PMID: 27005636]
  126. Pharmacol Rev. 2004 Sep;56(3):387-437 [PMID: 15317910]
  127. Mar Drugs. 2024 Sep 04;22(9): [PMID: 39330287]
  128. J Biol Chem. 2007 Aug 3;282(31):22254-66 [PMID: 17519235]
  129. Harmful Algae. 2016 Jan;51:81-88 [PMID: 28003063]
  130. Plant Cell Physiol. 2024 Jun 27;65(6):823-825 [PMID: 38808362]
  131. J Biol Chem. 2009 Aug 28;284(35):23636-43 [PMID: 19520854]
  132. PLoS One. 2023 Apr 27;18(4):e0284656 [PMID: 37104376]
  133. Mar Drugs. 2023 Dec 06;21(12): [PMID: 38132950]
  134. Nutrients. 2024 Sep 23;16(18): [PMID: 39339823]
  135. Front Bioeng Biotechnol. 2023 Mar 31;11:1146881 [PMID: 37064250]
  136. Microbiologyopen. 2023 Feb;12(1):e1343 [PMID: 36825881]
  137. Lancet. 1999 Jan 23;353(9149):307-14 [PMID: 9929039]
  138. Mol Nutr Food Res. 2023 Mar;67(6):e2200253 [PMID: 36683256]
  139. Front Nutr. 2025 Jan 15;11:1543087 [PMID: 39882035]
  140. Plant Physiol. 2018 Nov;178(3):1344-1357 [PMID: 30237205]
  141. Trends Pharmacol Sci. 1999 Apr;20(4):162-70 [PMID: 10322502]
  142. J Immunol. 2002 Oct 1;169(7):3963-9 [PMID: 12244197]
  143. Phytochemistry. 2014 Jun;102:74-9 [PMID: 24629803]
  144. Obstet Gynecol. 2009 Aug;114(2 Pt 1):386-397 [PMID: 19623003]
  145. Biotechnol Adv. 2001 Sep;19(5):387-97 [PMID: 14538074]
  146. Int J Mol Sci. 2023 Jan 11;24(2): [PMID: 36674907]
  147. Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2114739119 [PMID: 35302892]
  148. Mar Environ Res. 2024 Apr;196:106395 [PMID: 38382127]
  149. Biotechnol Bioeng. 2021 Jul;118(7):2734-2743 [PMID: 33851720]
  150. Microorganisms. 2022 Aug 04;10(8): [PMID: 36013989]
  151. Mar Biotechnol (NY). 2023 Apr;25(2):272-280 [PMID: 36856914]
  152. Mutat Res. 2010 Aug 7;690(1-2):12-23 [PMID: 19799917]
  153. Int J Mol Sci. 2023 Jan 20;24(3): [PMID: 36768438]
  154. Foods. 2023 Oct 23;12(20): [PMID: 37893770]
  155. Int Angiol. 2010 Apr;29(2 Suppl):19-27 [PMID: 20357745]
  156. Chem Rev. 2011 Oct 12;111(10):5817-20 [PMID: 21951202]
  157. Mar Drugs. 2024 Apr 19;22(4): [PMID: 38667802]
  158. Nat Commun. 2018 Sep 25;9(1):3924 [PMID: 30254261]
  159. Mar Drugs. 2024 May 09;22(5): [PMID: 38786607]
  160. Biotechnol Bioeng. 2018 Feb;115(2):331-340 [PMID: 28976541]
  161. Eur J Med Chem. 2001 Feb;36(2):109-26 [PMID: 11311743]
  162. ISME J. 2017 Jul;11(7):1722-1726 [PMID: 28350392]
  163. Mar Drugs. 2019 Jul 23;17(7): [PMID: 31340503]
  164. Nutrients. 2024 Dec 29;17(1): [PMID: 39796527]
  165. Drug Discov Today. 2017 Jan;22(1):57-71 [PMID: 27506873]
  166. Front Plant Sci. 2023 Jan 19;14:1077347 [PMID: 36743481]
  167. Front Nutr. 2024 Feb 06;11:1293909 [PMID: 38379539]
  168. New Phytol. 2023 Apr;238(1):438-452 [PMID: 36307966]
  169. Evid Based Complement Alternat Med. 2022 Dec 27;2022:3971967 [PMID: 36605100]
  170. Prog Lipid Res. 2017 Oct;68:83-108 [PMID: 28923590]
  171. Microorganisms. 2022 Mar 30;10(4): [PMID: 35456794]
  172. J Biol Chem. 2005 Oct 21;280(42):35562-70 [PMID: 16100121]
  173. Biochem Biophys Rep. 2017 Mar 15;10:82-87 [PMID: 28955738]
  174. Clin Immunol. 2024 Aug;265:110298 [PMID: 38909972]
  175. J Clin Invest. 2001 Jun;107(11):1339-45 [PMID: 11390413]
  176. J Lipid Res. 2001 Oct;42(10):1521-42 [PMID: 11590208]
  177. Free Radic Biol Med. 2007 Jun 15;42(12):1791-6 [PMID: 17512458]
  178. Plant Physiol. 2018 May;177(1):181-193 [PMID: 29555786]
  179. Placenta. 2021 Jan 15;104:208-219 [PMID: 33429118]
  180. Int Immunol. 2019 Aug 23;31(9):597-606 [PMID: 30926983]
  181. ACS Synth Biol. 2019 Jan 18;8(1):57-69 [PMID: 30525458]
  182. Plant Physiol. 2016 Aug;171(4):2468-82 [PMID: 27325666]
  183. Front Pharmacol. 2022 Oct 12;13:1015338 [PMID: 36313286]
  184. Am J Med. 1999 May 31;106(5B):37S-42S [PMID: 10390126]
  185. Nat New Biol. 1971 Jun 23;231(25):232-5 [PMID: 5284360]
  186. Expert Opin Investig Drugs. 1997 Jan;6(1):7-16 [PMID: 15989557]
  187. J Immunother Cancer. 2020 Jun;8(1): [PMID: 32554609]
  188. Eur J Rheumatol. 2017 Sep;4(3):210-218 [PMID: 29164003]
  189. Plants (Basel). 2020 Apr 08;9(4): [PMID: 32276527]
  190. J Immunol. 2012 Jan 1;188(1):21-8 [PMID: 22187483]
  191. Mar Drugs. 2020 Feb 13;18(2): [PMID: 32069885]
  192. Front Bioeng Biotechnol. 2022 Mar 17;10:842797 [PMID: 35372289]
  193. Mar Drugs. 2022 Jun 30;20(7): [PMID: 35877733]
  194. BMJ. 2022 Jan 26;376:e066452 [PMID: 35082139]
  195. Mar Drugs. 2024 Nov 06;22(11): [PMID: 39590785]
  196. Curr Opin Biotechnol. 2022 Apr;74:1-7 [PMID: 34749062]
  197. Int Immunopharmacol. 2011 Oct;11(10):1599-605 [PMID: 21635971]
  198. Mar Drugs. 2021 Feb 18;19(2): [PMID: 33670628]
  199. Recent Pat Inflamm Allergy Drug Discov. 2019;13(2):105-114 [PMID: 31814546]
  200. Analyst. 2018 Sep 24;143(19):4526-4536 [PMID: 30128447]
  201. Exp Cell Res. 1998 May 25;241(1):222-9 [PMID: 9633531]
  202. Biochimie. 2020 Nov;178:15-25 [PMID: 32389760]
  203. ISME J. 2011 Jun;5(6):1057-60 [PMID: 21160536]
  204. Crit Rev Food Sci Nutr. 2024;64(29):10564-10582 [PMID: 37357914]
  205. Nutrients. 2019 May 29;11(6): [PMID: 31146462]
  206. Arthritis Res Ther. 2008;10(4):212 [PMID: 18771589]
  207. Biomolecules. 2020 Jul 18;10(7): [PMID: 32708411]
  208. Molecules. 2022 Mar 03;27(5): [PMID: 35268778]
  209. Nutrients. 2021 Jan 28;13(2): [PMID: 33525643]
  210. Prostaglandins Leukot Essent Fatty Acids. 2014 Oct;91(4):141-8 [PMID: 25123060]
  211. Life (Basel). 2024 Mar 28;14(4): [PMID: 38672718]
  212. Mar Drugs. 2013 Nov 13;11(11):4558-69 [PMID: 24232669]
  213. ACS ES T Eng. 2024 Nov 25;5(1):36-49 [PMID: 39816185]
  214. Clin Ophthalmol. 2016 Oct 18;10:2035-2050 [PMID: 27799730]
  215. Free Radic Biol Med. 2015 Sep;86:269-78 [PMID: 25911196]
  216. J Agric Food Chem. 2021 Sep 1;69(34):9837-9848 [PMID: 34414763]
  217. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9383-7 [PMID: 2123555]
  218. Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:165-75 [PMID: 12432916]
  219. Eur J Clin Nutr. 2023 Jun;77(6):637-651 [PMID: 35701524]
  220. Mar Drugs. 2015 Jun 09;13(6):3672-709 [PMID: 26065408]
  221. Plant Cell. 2006 Mar;18(3):665-75 [PMID: 16473965]
  222. Prostaglandins Other Lipid Mediat. 2013 Dec;107:95-102 [PMID: 23644158]

MeSH Term

Humans
Phytoplankton
Lipids
Animals
Inflammation
Aquatic Organisms
Microalgae
Immunologic Factors

Chemicals

Lipids
Immunologic Factors
Journal Article Review
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0phytoplanktonlipidsMarineimmunomodulatorybioactiveBLsconditionseukaryoticmicroalgallipidmetaboliteseicosanoidsmarineclinicalemergingsourcephysiologicalgrowthuponstresschallengesseveralspeciesaccumulateresembleprecursorsanimalmediatorsinflammation:prostaglandinsThereforeservebiotechnologicalplatformproducefunctionaltherapeuticapplicationsmanagementchronicinflammatorydiseasesHowevercommerciallycompetitivelipidicprecursoryieldsenhancedBesidetailoringcultivationnativeproducersgeneticengineeringfeasiblestrategyaccrueproductionintroduceheterologousbiosyntheticpathwayshostspresentstate-of-the-artresearchdiscusssyntheticbiologyapproachesboostlight-drivenbiosynthesisPhytoplanktonBioactiveLipidsPerspectivesClinicalInflammationdiatomsinflammationmicroalgae

Similar Articles

Cited By

No available data.