Biocompatible Black Phosphorus Nanosheets-Antimicrobial Peptide Nanocomposites for Enhanced Anti-Infection Therapy.
Shuo Liu, Zhishang Shi, Lin Teng, Junlian Nie, Libing Zhang
Author Information
Shuo Liu: School of Energy and Chemical Engineering, Tianjin Renai College, Tianjin 301636, China.
Zhishang Shi: College of Life Sciences, Nankai University, Tianjin 300071, China. ORCID
Lin Teng: School of Energy and Chemical Engineering, Tianjin Renai College, Tianjin 301636, China.
Junlian Nie: School of Energy and Chemical Engineering, Tianjin Renai College, Tianjin 301636, China.
Libing Zhang: Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China.
Bacterial infections are one of the major problems affecting human health, which is exacerbated by increasing antibiotic resistance. Antimicrobial peptides (AMPs) are an ideal alternative to antibiotics, but their instability and toxicity to mammalian cells need to be addressed. Here, black phosphorus nanosheets (BPs) were successfully decorated with melittin (Mel), a kind of AMP, through electrostatic interaction. The size impacts of BPs on the antibacterial ability and biocompatibility of BPs/Mel nanocomposites were studied systematically. Results showed that the nanocomposites made from middle-sized BPs (BPs/Mel-7) have strong antibacterial ability as well as good biocompatibility. Moreover, BPs/Mel-7 could accelerate skin wound healing infected by . This study provides a facile strategy to expand the application of AMPs.
