A Semi-Micro Extraction Spectrophotometric Determination of Iron Using 4-Nitrocatechol and Xylometazoline Hydrochloride.
Petya V Racheva, Antoaneta D Saravanska, Galya K Toncheva, Denitsa D Kiradzhiyska, Nikolina P Milcheva, Vidka V Divarova, Ina P Pencheva, Kirila T Stojnova, Vassil B Delchev, Kiril B Gavazov
Author Information
Petya V Racheva: Department of Chemical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 120 Buxton Bros Str., 4004 Plovdiv, Bulgaria. ORCID
Antoaneta D Saravanska: Department of Chemical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 120 Buxton Bros Str., 4004 Plovdiv, Bulgaria.
Galya K Toncheva: Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, University of Plovdiv 'Paisii Hilendarski', 24 Tsar Assen St., 4000 Plovdiv, Bulgaria.
Denitsa D Kiradzhiyska: Department of Chemical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 120 Buxton Bros Str., 4004 Plovdiv, Bulgaria. ORCID
Nikolina P Milcheva: Department of Chemical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 120 Buxton Bros Str., 4004 Plovdiv, Bulgaria. ORCID
Vidka V Divarova: Department of Chemical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 120 Buxton Bros Str., 4004 Plovdiv, Bulgaria.
Ina P Pencheva: Department of Chemical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 120 Buxton Bros Str., 4004 Plovdiv, Bulgaria.
Kirila T Stojnova: Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, University of Plovdiv 'Paisii Hilendarski', 24 Tsar Assen St., 4000 Plovdiv, Bulgaria. ORCID
Vassil B Delchev: Department of Physical Chemistry, Faculty of Chemistry, University of Plovdiv 'Paisii Hilendarski', 24 Tsar Assen St., 4000 Plovdiv, Bulgaria. ORCID
Kiril B Gavazov: Department of Chemical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 120 Buxton Bros Str., 4004 Plovdiv, Bulgaria. ORCID
A chromogenic solvent extraction system for Fe(III) based on 4-nitrocatechol (4NC) and xylometazoline hydrochloride (XMH) was investigated. The optimum conditions for extraction spectrophotometric determination of iron were found. Under these conditions, the formula of the extracted complex was (XMH)[Fe(4NC)] and the apparent molar absorption coefficient at = 464 nm was 1.9 × 10 dm mol cm (4-fold enrichment). To validate the aforementioned formula and gather information about the spin state of the central Fe(III) ion, a combined experimental-theoretical approach was employed. This approach entailed the experimental determination of the 4NC:Fe and XMH:Fe molar ratios and the optimization of potential color-bearing structures utilizing the B3LYP/6-311G computational chemistry method. The effect of foreign ions was thoroughly examined, and a sensitive, simple, and inexpensive analytical procedure was proposed, which was successfully applied for determining iron in pharmaceutical and industrial samples.
