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Pharmaceuticals (Basel, Switzerland)
Feb 12, 2025;18 (2):

Role of Polyphenols in Dermatological Diseases: Exploring Pharmacotherapeutic Mechanisms and Clinical Implications.

Juan Salazar, Ángel Ortega, José Luis Pérez, Bermary Garrido, Raquel Santeliz, Néstor Galbán, Maria Paula Díaz, Raquel Cano, Gabriel Cano, Julio Cesar Contreras-Velasquez, Maricarmen Chacín
Author Information
  1. Juan Salazar: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela. ORCID
  2. Ángel Ortega: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela. ORCID
  3. José Luis Pérez: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela. ORCID
  4. Bermary Garrido: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela. ORCID
  5. Raquel Santeliz: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela. ORCID
  6. Néstor Galbán: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela. ORCID
  7. Maria Paula Díaz: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela. ORCID
  8. Raquel Cano: Clínica General del Norte, Grupo de Estudio e Investigación en Salud, Barranquilla 080002, Colombia. ORCID
  9. Gabriel Cano: Institut für Pharmazie Königin-Luise, Freie Universität Berlin, Strasse 2-4, 14195 Berlin, Germany. ORCID
  10. Julio Cesar Contreras-Velasquez: Departamento de Productividad e Innovación, Universidad de la Costa, Barranquilla 080002, Colombia. ORCID
  11. Maricarmen Chacín: Centro de Investigaciones en Ciencias de la Vida (CICV), Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia. ORCID
PMID: 40006060 DOI: 10.3390/ph18020247

Abstract

Although not frequently lethal, dermatological diseases represent a common cause of consultation worldwide. Due to the natural and non-invasive approach of phytotherapy, research for novel alternatives, such as polyphenols, to treat skin disorders is a subject of interest in modern medicine. Polyphenols, in particular, have been considered because of their anti-inflammatory, antitumoral, antimicrobial, and antioxidant properties, low molecular weight, and lipophilic nature that enables the passage of these compounds through the skin barrier. This review discusses the treatment of common dermatological diseases such as acne vulgaris, fungal infections, dermatitis, alopecia, and skin cancer, using polyphenols as therapeutic and prophylactic options. The specific molecules considered for each disorder, mechanisms of action, current clinical trials, and proposed applications are also reviewed.

Keywords

phytotherapy polyphenols skin disorders

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