OpenLB
Open Library of Bioscience
Advanced Search
Viruses
Jan 27, 2025;17 (2):

Bussuquara Virus: A Neglected Orthoflavivirus with Broad Distribution Across Central and South America and the Caribbean.

Madeline R Steck, Michaela Buenemann, Nikos Vasilakis
Author Information
  1. Madeline R Steck: Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0610, USA. ORCID
  2. Michaela Buenemann: Department of Geography and Environmental Studies, New Mexico State University, Las Cruces, NM 88003, USA. ORCID
  3. Nikos Vasilakis: Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0610, USA. ORCID
PMID: 40006938 DOI: 10.3390/v17020183

Abstract

Bussuquara virus (BSQV) was first discovered in the Brazilian Amazon in 1956. It is an arthropod-borne virus (arbovirus) in the genus , family . Since its discovery, BSQV has been sporadically detected across the South (Brazil, Columbia, and Argentina) and Central (Panama and Mexico) America and the Caribbean (Grenada), but there is minimal BSQV surveillance due to limited public health awareness and a lack of specific or sensitive diagnostics. BSQV exposure has been reported in a wide range of host and vector species, including humans. Little information is available in the literature and herein we summarize the published historical findings on BSQV and suggest a pathway for future studies to better understand its potential emergence into human populations.

Keywords

clinical manifestations mosquito-borne virus orthoflavivirus transmission cycles

References

  1. Food Environ Virol. 2022 Mar;14(1):10-29 [PMID: 34694573]
  2. Am J Trop Med Hyg. 1998 Sep;59(3):357-62 [PMID: 9749625]
  3. Arch Virol. 2020 Aug;165(8):1863-1868 [PMID: 32474687]
  4. Viruses. 2020 Aug 29;12(9): [PMID: 32872425]
  5. J Immunol. 1960 Jun;84:590-8 [PMID: 14400990]
  6. One Health. 2017 Jul 01;4:1-13 [PMID: 28785601]
  7. J Gen Virol. 1988 Aug;69 ( Pt 8):1913-20 [PMID: 2841406]
  8. Enferm Infecc Microbiol Clin. 2008 Jan;26(1):10-5 [PMID: 18208760]
  9. Am J Epidemiol. 1966 Nov;84(3):467-77 [PMID: 6005906]
  10. Pathogens. 2023 Dec 06;12(12): [PMID: 38133304]
  11. Mil Med. 1974 Jun;141(6):449-53 [PMID: 4208719]
  12. Int J Mol Sci. 2021 Apr 03;22(7): [PMID: 33916729]
  13. Mem Inst Oswaldo Cruz. 2003 Apr;98(3):379-82 [PMID: 12886419]
  14. Proc Soc Exp Biol Med. 1959 Jun;101(2):275-9 [PMID: 13675210]
  15. J Clin Microbiol. 2003 Jun;41(6):2676-9 [PMID: 12791902]
  16. J Gen Virol. 1974 Apr;23(1):91-6 [PMID: 4833603]
  17. J Gen Virol. 2024 Oct;105(9): [PMID: 39351896]
  18. Parasit Vectors. 2010 Apr 08;3(1):35 [PMID: 20377873]
  19. J Venom Anim Toxins Incl Trop Dis. 2014 Jul 03;20:29 [PMID: 25013410]
  20. J Gen Virol. 1968 Mar;2(2):273-84 [PMID: 5654765]
  21. PLoS One. 2018 Jun 13;13(6):e0199071 [PMID: 29897990]
  22. Am J Trop Med Hyg. 1966 May;15(3):385-400 [PMID: 4380043]
  23. Emerg Infect Dis. 2021 Sep;27(9):2466-2470 [PMID: 34424166]
  24. PLoS Negl Trop Dis. 2016 Sep 21;10(9):e0005017 [PMID: 27654806]
  25. Nat Rev Microbiol. 2004 Oct;2(10):789-801 [PMID: 15378043]
  26. Arch Med Res. 2002 Jul-Aug;33(4):330-42 [PMID: 12234522]
  27. mBio. 2024 Dec 11;15(12):e0294624 [PMID: 39480108]
  28. Braz J Infect Dis. 2021 Mar-Apr;25(2):101542 [PMID: 33587923]
  29. Front Genet. 2018 Dec 04;9:595 [PMID: 30564270]
  30. Intervirology. 1993;36(3):144-52 [PMID: 8150595]
  31. J Microsc. 2004 Oct;216(Pt 1):5-14 [PMID: 15369478]
  32. J Gen Virol. 2022 Jan;103(1): [PMID: 35077341]
  33. Am J Trop Med Hyg. 1980 Jul;29(4):657-66 [PMID: 6105826]
  34. PLoS Negl Trop Dis. 2014 Feb 13;8(2):e2706 [PMID: 24551266]
  35. Clin Infect Dis. 2019 Sep 27;69(8):1353-1359 [PMID: 30561554]
  36. J Med Primatol. 2019 Aug;48(4):211-217 [PMID: 31032984]
  37. J Clin Microbiol. 2005 Feb;43(2):696-702 [PMID: 15695666]
  38. Microorganisms. 2020 Aug 01;8(8): [PMID: 32752150]
  39. Mem Inst Oswaldo Cruz. 2017 Aug;112(8):532-536 [PMID: 28767977]
  40. PLoS Negl Trop Dis. 2020 Jun 10;14(6):e0008343 [PMID: 32520944]
  41. Diagnostics (Basel). 2020 May 14;10(5): [PMID: 32423058]
  42. Zoonoses Public Health. 2018 Aug;65(5):505-511 [PMID: 29575672]
  43. Sci Transl Med. 2017 May 3;9(388): [PMID: 28469032]
  44. Mil Med. 1973 May;138(5):271-5 [PMID: 4196452]
  45. Trans R Soc Trop Med Hyg. 1971;65(4):541-2 [PMID: 5107116]
  46. Nat Microbiol. 2020 Jun;5(6):796-812 [PMID: 32367055]
  47. Ecohealth. 2018 Dec;15(4):777-791 [PMID: 30117001]
  48. Bull Pan Am Health Organ. 1975;9(1):19-26 [PMID: 238693]
  49. Rev Inst Med Trop Sao Paulo. 2009 May-Jun;51(3):141-7 [PMID: 19551288]
  50. PLoS Negl Trop Dis. 2022 Jul 27;16(7):e0010602 [PMID: 35895718]
  51. Am J Trop Med Hyg. 1961 Mar;10:227-49 [PMID: 13691675]
  52. Mem Inst Oswaldo Cruz. 2016 Jan;111(1):20-9 [PMID: 26784852]
  53. Virulence. 2021 Dec;12(1):2814-2838 [PMID: 34696709]
  54. Nature. 2018 Aug;560(7720):573-581 [PMID: 30158602]
  55. Rev Argent Microbiol. 1998 Oct-Dec;30(4):170-5 [PMID: 9950038]
  56. Comp Med. 2017 Jun 1;67(3):232-241 [PMID: 28662752]
  57. Vector Borne Zoonotic Dis. 2003 Spring;3(1):3-9 [PMID: 12804375]
  58. Med Biol. 1975 Oct;53(5):400-5 [PMID: 1207193]
  59. Am J Trop Med Hyg. 1969 Mar;18(2):273-9 [PMID: 5777740]
  60. Am J Trop Med Hyg. 1983 Jul;32(4):854-61 [PMID: 6309027]
  61. Emerg Infect Dis. 2005 Aug;11(8):1167-73 [PMID: 16102302]
  62. J Gen Virol. 2001 Aug;82(Pt 8):1867-1876 [PMID: 11457992]
  63. PLoS One. 2015 Feb 26;10(2):e0117849 [PMID: 25719412]
  64. Asian Pac J Trop Med. 2016 Oct;9(10):968-972 [PMID: 27794390]
  65. PLoS Negl Trop Dis. 2017 Feb 10;11(2):e0005351 [PMID: 28187130]
  66. Viruses. 2024 Jun 14;16(6): [PMID: 38932252]
  67. An Microbiol (Rio J). 1968;15:35-51 [PMID: 4913570]
  68. Am J Trop Med Hyg. 1961 May;10:397-402 [PMID: 13708940]
  69. Emerg Microbes Infect. 2015 Mar;4(3):e18 [PMID: 26038768]
  70. Proc Soc Exp Biol Med. 1964 Jun;116:354-8 [PMID: 14189137]
  71. Viruses. 2023 Apr 10;15(4): [PMID: 37112917]
  72. Virol J. 2008 Jan 24;5:16 [PMID: 18218114]
  73. J Virol. 1998 Jan;72(1):73-83 [PMID: 9420202]
  74. J Venom Anim Toxins Incl Trop Dis. 2014 Mar 25;20(1):9 [PMID: 24666635]
  75. Front Med (Lausanne). 2021 Dec 08;8:769208 [PMID: 34957147]
  76. Viruses. 2019 Aug 22;11(9): [PMID: 31443500]
  77. Emerg Infect Dis. 2005 Sep;11(9):1497-8 [PMID: 16673523]
  78. Genome Announc. 2014 Sep 18;2(5): [PMID: 25237018]
  79. Emerg Infect Dis. 2003 Jul;9(7):857-9 [PMID: 12890328]

Grants

  1. T32 AI007526/NIAID NIH HHS
  2. U01 AI151807/NIAID NIH HHS
  3. U01AI151807/NIH HHS
  4. T32 AI007526-24/NIH HHS

MeSH Term

Humans
Caribbean Region
Animals
South America
Central America
Flavivirus
Phylogeny
Journal Article Review
Article has an altmetric score of 4

Word Cloud

Created with Highcharts 10.0.0BSQVvirusBussuquaraSouthCentralAmericaCaribbeanfirstdiscoveredBrazilianAmazon1956arthropod-bornearbovirusgenusfamilySincediscoverysporadicallydetectedacrossBrazilColumbiaArgentinaPanamaMexicoGrenadaminimalsurveillanceduelimitedpublichealthawarenesslackspecificsensitivediagnosticsexposurereportedwiderangehostvectorspeciesincludinghumansLittleinformationavailableliteraturehereinsummarizepublishedhistoricalfindingssuggestpathwayfuturestudiesbetterunderstandpotentialemergencehumanpopulationsVirus:NeglectedOrthoflavivirusBroadDistributionAcrossclinicalmanifestationsmosquito-borneorthoflavivirustransmissioncycles

Similar Articles

Cited By

No available data.