Shirong Li: Department of Infectious Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Haiwei Dou: Department of Infectious Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Dawei Shi: Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Ruijie Yuan: Department of Geriatric Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China.
Peng Tu: Department of Pediatrics, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Wuhan No.1 Hospital, Wuhan, China.
Qing Yuan: Department of Respiratory, Branch of Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Luoyang Hospital of TCM, Henan, China.
Deli Xin: Department of Infectious Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Wenjie Qi: Department of Infectious Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Introduction: is one of the important pathogens of community-acquired pneumonia (CAP), and P1 adhesin serves as a pathogenic protein and an immune protein involved in the pathogenesis of . The aim of this study was to investigate the P1 adhesin genotype in and its association with disease severity in patients with CAP from 2017 to 2019. Methods: was identified in patient samples by real-time quantitative polymerase chain reaction (qPCR). The P1 genotypes of samples were determined using a culture-independent P1 typing method. Results: In total, 1,907 clinical samples were collected from 13 tertiary hospitals in Beijing, Shenyang, and Baotou, including 1488 samples from children and 419 from adults. Of these, 820 samples (43.00%), including 777 from children and 43 from adults, were positive for . 797 samples were successfully typed using the culture-independent P1 typing method (P1-1, 605; P1- 2, 192). The detection rate and P1-1 detection rate differed significantly between children and adults (both < 0.01), with P1-1 remaining the dominant genotype. The proportion of P1-2 samples increased in children from 16.75% in 2017 to 28.76% in 2019. Discussion: No relationship between the P1 genotype and disease severity was identified. Monitoring the genotype changes of P1 adhesin in local populations may positively impact the epidemiological prevention and control of infections.
