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Mar, 2025;8 (3): e70525.

Impacts of Curcumin Supplementation on Cardiometabolic Risk Factors in Patients With Polycystic Ovary Syndrome: A Systematic Review and Dose-Response Meta-Analysis.

Shooka Mohammadi, Somayeh Ziaei, Mehrnaz Morvaridi, Motahareh Hasani, Elham Mirtaheri, Farnaz Farsi, Sara Ebrahimi, Elnaz Daneshzad, Javad Heshmati
Author Information
  1. Shooka Mohammadi: Nutrition and Metabolic Diseases Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran. ORCID
  2. Somayeh Ziaei: Departemt of Anesthesia, Imam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran.
  3. Mehrnaz Morvaridi: School of Public Health Iran University of Medical Sciences Tehran Iran.
  4. Motahareh Hasani: Department of Nutritional Sciences School of Health, Golestan University of Medical Sciences Gorgan Iran.
  5. Elham Mirtaheri: Department of Human Sciences Human Nutrition Program, The Ohio State University Columbus Ohio USA.
  6. Farnaz Farsi: Minimally Invasive Surgery Research Center Iran University of Medical Sciences Tehran Iran.
  7. Sara Ebrahimi: Institute for Physical Activity and Nutrition School of Exercise and Nutrition Sciences, Deakin University Geelong VIC Australia.
  8. Elnaz Daneshzad: Non-Communicable Diseases Research Center Alborz University of Medical Sciences Karaj Iran.
  9. Javad Heshmati: University of Ottawa Heart Institute Ottawa Canada. ORCID
PMID: 40041784 DOI: 10.1002/hsr2.70525

Abstract

Background and Aim: Patients with polycystic ovary syndrome (PCOS) commonly have cardiometabolic risk factors. Oxidative stress (OS) significantly contributes to the development of cardiometabolic diseases. Curcumin (CUR) exhibits antioxidant properties that aid in OS regulation. This systematic review and dose-response meta-analysis of randomized clinical trials (RCTs) evaluated the effects of CUR supplementation on cardiometabolic risk factors in women with PCOS.
Methods: A systematic search across various databases was implemented to identify eligible RCTs published until January 2024. A meta-analysis was conducted employing a random-effects model.
Results: Eight RCTs were included in the meta-analysis. It was indicated that CUR supplementation substantially reduced fasting blood sugar (FBS) (standardized mean difference [SMD]: -0.40 mg/dL, 95% confidence interval [CI]: -0.59, -0.21;  < 0.001), insulin (SMD: -0.32 µU/mL, 95% CI: -0.49, -0.14;  < 0.001), homeostasis model assessment of insulin resistance (HOMA-IR) (SMD: -0.36, 95% CI: -0.54, -0.19;  < 0.001), and total cholesterol (TC) (SMD: -0.34 mg/dL, 95% CI: -0.61, -0.08;  = 0.01). In addition, it substantially increased the quantitative insulin sensitivity check index (QUICKI) (SMD: 0.37, 95% CI: 0.13, 0.61;  < 0.001) in the CUR-treated group compared with the control group. However, CUR did not have significant impacts on body mass index (BMI), body weight, serum levels of follicle-stimulating hormone (FSH), triglycerides (TG), dehydroepiandrosterone (DHEA), high-density lipoprotein (HDL), testosterone, low-density lipoprotein (LDL), and luteinizing hormone (LH).
Conclusion: This study revealed that CUR may have the potential to enhance cardiometabolic health by reducing hyperglycemia, insulin resistance, and serum TC levels in women with PCOS.

Keywords

cardiometabolic cardiovascular curcumin polycystic ovary syndrome

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