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Journal of nanobiotechnology
Mar 06, 2025;23 (1): 178.

SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials.

Qian Cai, Rui Guo, Dafu Chen, Zixin Deng, Jiangtao Gao
Author Information
  1. Qian Cai: State Key Lab of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, Fujian, China.
  2. Rui Guo: National and Local United Engineering Laboratory of Natural Biotoxin, College of Bee and Biomedical Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
  3. Dafu Chen: National and Local United Engineering Laboratory of Natural Biotoxin, College of Bee and Biomedical Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
  4. Zixin Deng: State Key Laboratory of Microbial Metabolism, Joint International Laboratory on Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
  5. Jiangtao Gao: National and Local United Engineering Laboratory of Natural Biotoxin, College of Bee and Biomedical Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. jgaotao@gmail.com.
PMID: 40050980 DOI: 10.1186/s12951-025-03254-9

Abstract

Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental and clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic and programmable materials to yield engineered nanomaterials with emerging and specific functionalities. This review elucidates a comprehensive examination of synthetic biology's pivotal role in advancing engineered nanomaterials for targeted drug delivery systems. It begins with exploring the fundamental synergy between synthetic biology and nanotechnology, then highlights the current landscape of nanomaterials in targeted drug delivery applications. Subsequently, the review discusses the design of novel nanomaterials informed by biological principles, focusing on expounding the synthetic biology tools and the potential for developing advanced nanomaterials. Afterward, the research advances of innovative materials design through synthetic biology were systematically summarized, emphasizing the integration of genetic circuitry to program nanomaterial responses. Furthermore, the challenges, current weaknesses and opportunities, prospective directions, and ethical and societal implications of SynBioNanoDesign in drug delivery are elucidated. Finally, the review summarizes the transformative impact that synthetic biology may have on drug-delivery technologies in the future.

Keywords

Engineered nanomaterials Genetic circuitry Nanobiotechnology Personalized medicine Regulatory challenges Synthetic biology Targeted drug delivery

References

  1. Nat Methods. 2020 Sep;17(9):937-946 [PMID: 32778831]
  2. J Nanobiotechnology. 2021 Jun 26;19(1):190 [PMID: 34174890]
  3. Mater Today Bio. 2023 Mar 24;20:100612 [PMID: 37063776]
  4. Sci Adv. 2022 Jul 15;8(28):eabo6163 [PMID: 35857516]
  5. J Control Release. 2022 Feb;342:53-65 [PMID: 34971694]
  6. Curr Opin Biotechnol. 2011 Dec;22(6):901-8 [PMID: 21592772]
  7. Chem Soc Rev. 2019 Jul 15;48(14):3771-3810 [PMID: 31165801]
  8. Adv Sci (Weinh). 2023 Jul;10(20):e2207759 [PMID: 37129318]
  9. Expert Opin Drug Deliv. 2014 Jul;11(7):1087-101 [PMID: 24773227]
  10. Nat Mater. 2021 Mar;20(3):421-430 [PMID: 32895504]
  11. Acta Biomater. 2019 Feb;85:1-26 [PMID: 30579043]
  12. Protein Cell. 2011 Dec;2(12):973-89 [PMID: 22231356]
  13. Nat Nanotechnol. 2007 Dec;2(12):751-60 [PMID: 18654426]
  14. Small. 2022 Jun;18(22):e2200299 [PMID: 35521948]
  15. Chem Rev. 2021 Jun 9;121(11):6321-6372 [PMID: 34047544]
  16. Drugs. 2022 May;82(7):749-792 [PMID: 35596879]
  17. Antioxid Redox Signal. 2019 Feb 20;30(6):813-856 [PMID: 29634347]
  18. Adv Mater. 2019 Aug;31(33):e1902575 [PMID: 31215123]
  19. Adv Funct Mater. 2021 Jan 27;31(5): [PMID: 34366761]
  20. Nat Chem Biol. 2016 Dec;12(12):1089-1096 [PMID: 27775715]
  21. Nat Mater. 2018 Dec;17(12):1154-1163 [PMID: 30323334]
  22. Nat Mater. 2005 Dec;4(12):934-41 [PMID: 16299510]
  23. Curr Top Med Chem. 2024;24(8):686-721 [PMID: 38409730]
  24. Nat Methods. 2015 Nov;12(11):1051-4 [PMID: 26344044]
  25. Angew Chem Int Ed Engl. 2010 Sep 17;49(39):7019-24 [PMID: 20842627]
  26. Bioeng Transl Med. 2016 Jun 03;1(1):10-29 [PMID: 29313004]
  27. Adv Drug Deliv Rev. 2019 Nov - Dec;151-152:169-190 [PMID: 31071378]
  28. Nat Nanotechnol. 2022 Apr;17(4):337-346 [PMID: 35393599]
  29. Nature. 2019 Oct;574(7780):658-662 [PMID: 31666724]
  30. Nat Commun. 2024 Feb 29;15(1):1839 [PMID: 38424039]
  31. ACS Nano. 2019 Feb 26;13(2):1469-1478 [PMID: 30763076]
  32. Heliyon. 2022 Dec 13;8(12):e12193 [PMID: 36578390]
  33. Nat Rev Cancer. 2019 Apr;19(4):187-195 [PMID: 30837696]
  34. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14488-14493 [PMID: 28892587]
  35. Bioconjug Chem. 2018 Jul 18;29(7):2176-2180 [PMID: 29944344]
  36. J Nanobiotechnology. 2024 Jun 18;22(1):343 [PMID: 38890749]
  37. ACS Nano. 2020 Apr 28;14(4):3927-3940 [PMID: 32298077]
  38. J Nanobiotechnology. 2018 Sep 19;16(1):71 [PMID: 30231877]
  39. Chembiochem. 2019 Apr 15;20(8):994-1002 [PMID: 30589185]
  40. Front Bioeng Biotechnol. 2024 Jul 11;12:1436297 [PMID: 39055339]
  41. Chem Soc Rev. 2018 May 21;47(10):3530-3542 [PMID: 29400389]
  42. J Drug Target. 2008 Feb;16(2):108-23 [PMID: 18274932]
  43. Chin Med J (Engl). 2022 Sep 20;135(18):2178-2187 [PMID: 36209735]
  44. Appl Microbiol Biotechnol. 2021 Nov;105(21-22):8255-8264 [PMID: 34599676]
  45. Trends Biotechnol. 2018 Mar;36(3):242-251 [PMID: 29310843]
  46. Biomaterials. 2023 Apr;295:122036 [PMID: 36804660]
  47. J Mater Chem B. 2024 Jul 24;12(29):7001-7019 [PMID: 38919030]
  48. Regen Biomater. 2020 Aug;7(4):349-358 [PMID: 32793380]
  49. Nat Nanotechnol. 2023 Jun;18(6):657-666 [PMID: 36781994]
  50. J Mater Chem B. 2023 Mar 22;11(12):2568-2613 [PMID: 36883982]
  51. Small. 2024 Sep;20(36):e2402980 [PMID: 39058214]
  52. ACS Synth Biol. 2015 Jan 16;4(1):8-11 [PMID: 25592034]
  53. Nat Commun. 2020 Oct 14;11(1):5174 [PMID: 33057059]
  54. Drug Deliv. 2024 Dec;31(1):2390022 [PMID: 39138394]
  55. Bioeng Transl Med. 2017 Jan 19;2(1):43-57 [PMID: 29313023]
  56. Adv Sci (Weinh). 2024 Jul;11(26):e2401617 [PMID: 38713753]
  57. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2807-2812 [PMID: 28242683]
  58. Nanoscale. 2021 Nov 4;13(42):17854-17870 [PMID: 34671801]
  59. ACS Nano. 2023 Mar 14;17(5):5059-5071 [PMID: 36847803]
  60. Angew Chem Int Ed Engl. 2023 Oct 9;62(41):e202308413 [PMID: 37380606]
  61. Nat Commun. 2018 Jun 15;9(1):2353 [PMID: 29907774]
  62. Cell. 2018 Jun 14;173(7):1581-1592 [PMID: 29887378]
  63. Biomacromolecules. 2021 Feb 8;22(2):540-545 [PMID: 33320659]
  64. Small. 2008 Nov;4(11):2025-34 [PMID: 18855973]
  65. Clin Cancer Res. 2001 Feb;7(2):223-5 [PMID: 11234871]
  66. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2868-73 [PMID: 26929348]
  67. Nanoscale Horiz. 2024 Dec 16;10(1):38-55 [PMID: 39499543]
  68. ACS Infect Dis. 2020 Aug 14;6(8):2120-2129 [PMID: 32673475]
  69. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2579-86 [PMID: 22949671]
  70. Exploration (Beijing). 2022 Jun 04;2(4):20220008 [PMID: 37325605]
  71. Science. 2013 May 3;340(6132):595-9 [PMID: 23579496]
  72. Nat Commun. 2019 Feb 5;10(1):609 [PMID: 30723211]
  73. Angew Chem Int Ed Engl. 2024 Jul 8;63(28):e202404822 [PMID: 38687056]
  74. Adv Drug Deliv Rev. 2019 Mar 15;143:3-21 [PMID: 30639257]
  75. Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8709-8714 [PMID: 30975744]
  76. iScience. 2024 Oct 09;27(11):111112 [PMID: 39502285]
  77. ACS Nano. 2024 Aug 13;18(32):21112-21124 [PMID: 39094075]
  78. Nat Rev Drug Discov. 2009 Feb;8(2):111-28 [PMID: 19180105]
  79. Nature. 2018 Jan 3;553(7686):86-90 [PMID: 29300010]
  80. Chem Rev. 2016 May 11;116(9):5338-431 [PMID: 27109701]
  81. J Mater Chem B. 2024 Jan 17;12(3):609-636 [PMID: 38126443]
  82. Biomedicines. 2022 Sep 02;10(9): [PMID: 36140280]
  83. Adv Mater. 2019 Apr;31(16):e1808278 [PMID: 30803049]
  84. Adv Sci (Weinh). 2024 Jun;11(21):e2308910 [PMID: 38582507]
  85. Macromol Biosci. 2024 Jul;24(7):e2300590 [PMID: 38488862]
  86. ACS Synth Biol. 2018 Jul 20;7(7):1825-1828 [PMID: 29913065]
  87. Nat Rev Cancer. 2017 Jan;17(1):20-37 [PMID: 27834398]
  88. Exp Mol Pathol. 2009 Jun;86(3):215-23 [PMID: 19186176]
  89. Adv Drug Deliv Rev. 2022 Mar;182:114115 [PMID: 35077821]
  90. Nat Commun. 2023 Mar 23;14(1):1606 [PMID: 36959204]
  91. Science. 1998 Jan 16;279(5349):377-80 [PMID: 9430587]
  92. Nat Mater. 2019 Oct;18(10):1124-1132 [PMID: 31133730]
  93. ACS Nano. 2025 Jan 28;19(3):3424-3438 [PMID: 39797815]
  94. Nat Chem Biol. 2018 Jan;14(1):86-93 [PMID: 29083418]
  95. Science. 2021 Jun 11;372(6547): [PMID: 34112665]
  96. Nat Biotechnol. 2003 Oct;21(10):1171-8 [PMID: 14520402]
  97. Nat Immunol. 2021 Feb;22(2):111-117 [PMID: 33495644]
  98. Sci China Life Sci. 2020 Aug;63(8):1099-1102 [PMID: 32557290]
  99. Curr Opin Biotechnol. 2014 Aug;28:75-82 [PMID: 24832078]
  100. ACS Nano. 2024 Jan 23;18(3):2195-2209 [PMID: 38194222]
  101. Nat Nanotechnol. 2020 Apr;15(4):313-320 [PMID: 32251383]
  102. ACS Appl Mater Interfaces. 2015 Oct 14;7(40):22578-86 [PMID: 26413999]
  103. J Am Chem Soc. 2020 Jan 22;142(3):1406-1416 [PMID: 31820959]
  104. Cold Spring Harb Perspect Biol. 2016 Jul 01;8(7): [PMID: 27194045]
  105. Nat Biomed Eng. 2021 Sep;5(9):1038-1047 [PMID: 33903744]
  106. Pharmaceutics. 2024 May 16;16(5): [PMID: 38794336]
  107. Nat Chem. 2020 Nov;12(11):1067-1075 [PMID: 32895523]
  108. Biomaterials. 2021 May;272:120809 [PMID: 33839624]
  109. Small. 2024 Aug;20(33):e2311584 [PMID: 38566551]
  110. Nature. 2017 Dec 6;552(7683):84-87 [PMID: 29219963]
  111. Chem Soc Rev. 2023 Mar 20;52(6):2031-2081 [PMID: 36633202]
  112. ACS Nano. 2021 Apr 27;15(4):6326-6339 [PMID: 33724785]
  113. Adv Mater. 2024 May;36(21):e2312897 [PMID: 38346008]
  114. ACS Nano. 2024 Oct 8;18(40):27764-27781 [PMID: 39342648]
  115. ACS Appl Mater Interfaces. 2020 Jan 8;12(1):126-134 [PMID: 31800209]
  116. Nat Nanotechnol. 2019 Nov;14(11):1007-1017 [PMID: 31695150]
  117. Nat Rev Cancer. 2022 May;22(5):259-279 [PMID: 35194172]
  118. Nat Rev Cancer. 2022 Oct;22(10):550-556 [PMID: 35941223]
  119. Nature. 2014 Mar 27;507(7493):519-22 [PMID: 24531764]
  120. Nat Biotechnol. 2018 Sep;36(8):707-716 [PMID: 29985479]
  121. Acta Biomater. 2020 Jul 1;110:221-230 [PMID: 32422317]
  122. Chem Rev. 2023 Mar 8;123(5):2049-2111 [PMID: 36692900]
  123. J Cell Physiol. 2020 May;235(5):4618-4630 [PMID: 31674023]
  124. Nano Lett. 2006 Aug;6(8):1794-807 [PMID: 16895376]
  125. Mol Pharm. 2020 Jul 6;17(7):2612-2627 [PMID: 32459098]
  126. Small. 2022 Dec;18(49):e2203999 [PMID: 36316233]
  127. Nanomedicine (Lond). 2021 Dec;16(30):2725-2741 [PMID: 34870452]
  128. Trends Pharmacol Sci. 2022 Mar;43(3):171-187 [PMID: 35086691]
  129. Nat Mater. 2022 Nov;21(11):1324-1332 [PMID: 36138145]
  130. Nat Commun. 2019 Dec 6;10(1):5580 [PMID: 31811125]
  131. ACS Nano. 2014 Aug 26;8(8):7896-904 [PMID: 25020109]
  132. Nano Lett. 2010 Oct 13;10(10):3863-7 [PMID: 20845914]
  133. ACS Nano. 2017 May 23;11(5):4528-4541 [PMID: 28423276]
  134. Curr Opin Biotechnol. 2013 Aug;24(4):551-4 [PMID: 23856593]
  135. Biology (Basel). 2020 Jul 30;9(8): [PMID: 32751710]
  136. Nanoscale. 2019 Nov 21;11(45):21811-21823 [PMID: 31691701]
  137. Pharmaceutics. 2020 Mar 25;12(4): [PMID: 32218326]
  138. Biomed Mater. 2024 Oct 25;19(6): [PMID: 39419089]
  139. Bioorg Chem. 2020 Jan;94:103423 [PMID: 31776035]
  140. ACS Nano. 2008 Jun;2(6):1101-7 [PMID: 19206325]
  141. Science. 2020 Jul 17;369(6501):333-337 [PMID: 32675376]
  142. Nat Commun. 2021 Jan 21;12(1):493 [PMID: 33479209]
  143. Nat Nanotechnol. 2020 Oct;15(10):819-829 [PMID: 32895522]
  144. J Control Release. 2024 May;369:746-764 [PMID: 38599547]
  145. Sci Technol Adv Mater. 2013 Dec 3;15(1):014401 [PMID: 27877637]
  146. Nat Biotechnol. 2017 Nov;35(11):1094-1101 [PMID: 29035374]
  147. Nature. 2010 Jan 21;463(7279):288-90 [PMID: 20090726]
  148. Nat Rev Chem. 2020 Dec;4(12):638-656 [PMID: 37127973]
  149. Nat Methods. 2014 May;11(5):508-20 [PMID: 24781324]
  150. Angew Chem Int Ed Engl. 2023 Feb 1;62(6):e202213336 [PMID: 36218046]
  151. Small. 2012 Jan 23;8(2):310-6 [PMID: 22102552]
  152. Adv Drug Deliv Rev. 2025 Jan;216:115481 [PMID: 39617254]
  153. Int J Nanomedicine. 2024 Jan 18;19:571-608 [PMID: 38260239]
  154. Biomaterials. 2016 Mar;83:308-20 [PMID: 26796043]
  155. J Nanobiotechnology. 2023 Aug 22;21(1):287 [PMID: 37608298]
  156. Drug Deliv. 2024 Dec;31(1):2361165 [PMID: 38832506]
  157. Nanotoxicology. 2013 Feb;7(1):61-70 [PMID: 22047094]
  158. Biomolecules. 2024 Aug 07;14(8): [PMID: 39199348]
  159. Trends Biotechnol. 2024 Mar;42(3):258-260 [PMID: 37980185]
  160. Nat Nanotechnol. 2019 Jul;14(7):626 [PMID: 31270443]
  161. Nat Mater. 2013 Nov;12(11):958-62 [PMID: 24150413]
  162. Angew Chem Int Ed Engl. 2020 Jun 2;59(23):8786-8798 [PMID: 31901003]
  163. Adv Drug Deliv Rev. 2022 Apr;183:114173 [PMID: 35217112]
  164. Drug Deliv. 2018 Nov;25(1):1362-1371 [PMID: 29869563]
  165. Trends Biotechnol. 2024 Apr;42(4):389-392 [PMID: 37957090]
  166. Cell. 2020 Feb 20;180(4):688-702.e13 [PMID: 32084340]
  167. Theranostics. 2019 Aug 12;9(20):5886-5898 [PMID: 31534526]
  168. Nat Biotechnol. 2007 Oct;25(10):1149-57 [PMID: 17873866]
  169. Int J Nanomedicine. 2019 Jul 11;14:5159-5173 [PMID: 31371954]
  170. Nat Commun. 2024 Sep 17;15(1):8172 [PMID: 39289401]
  171. Int J Nanomedicine. 2017 Dec 28;13:199-208 [PMID: 29343958]
  172. Res Pract Thromb Haemost. 2018 Feb 19;2(2):188-198 [PMID: 30046721]
  173. Adv Mater. 2018 May;30(19):e1704636 [PMID: 29436028]
  174. Adv Mater. 2017 Jun;29(23): [PMID: 28370546]
  175. Nat Commun. 2022 Apr 1;13(1):1736 [PMID: 35365617]
  176. Nat Nanotechnol. 2011 Apr 24;6(6):377-84 [PMID: 21516089]
  177. Polymers (Basel). 2021 May 24;13(11): [PMID: 34074020]
  178. Annu Rev Biomed Eng. 2020 Jun 4;22:51-77 [PMID: 32151150]
  179. Carbohydr Polym. 2021 Nov 15;272:118491 [PMID: 34420747]
  180. Chem Rev. 2024 May 8;124(9):5505-5616 [PMID: 38626459]
  181. Small. 2005 Mar;1(3):325-7 [PMID: 17193451]
  182. Sci Transl Med. 2012 Apr 4;4(128):128ra39 [PMID: 22491949]
  183. Chem Rec. 2024 Sep;24(9):e202400087 [PMID: 39148157]
  184. Small. 2010 Jan;6(1):138-44 [PMID: 19743433]
  185. Nano Lett. 2019 Sep 11;19(9):5885-5896 [PMID: 31117696]
  186. Int J Nanomedicine. 2017 Oct 11;12:7433-7451 [PMID: 29066893]
  187. J Nanobiotechnology. 2023 Jul 6;21(1):211 [PMID: 37415158]
  188. Adv Drug Deliv Rev. 2018 Mar 15;128:84-100 [PMID: 29567396]
  189. Cell. 2014 Jun 5;157(6):1262-1278 [PMID: 24906146]
  190. Small. 2024 Jul;20(28):e2310531 [PMID: 38287729]
  191. Adv Mater. 2024 Jun;36(26):e2312169 [PMID: 38361435]
  192. Bioeng Transl Med. 2019 Sep 05;4(3):e10143 [PMID: 31572799]
  193. Nanoscale. 2015 Oct 7;7(37):15332-40 [PMID: 26332204]
  194. Nat Rev Mater. 2021 Feb;6(2):103-106 [PMID: 36117545]
  195. Ther Deliv. 2024;15(7):489-493 [PMID: 38979583]
  196. Signal Transduct Target Ther. 2024 Jan 1;9(1):1 [PMID: 38161204]
  197. Nanomedicine (Lond). 2024 Jun 20;19(15):1347-1368 [PMID: 39105753]
  198. ACS Nano. 2017 Aug 22;11(8):7901-7914 [PMID: 28686416]
  199. Nano Lett. 2010 Jul 14;10(7):2714-20 [PMID: 20575574]
  200. Nat Mater. 2020 May;19(5):566-575 [PMID: 31932672]
  201. Front Microbiol. 2021 Mar 16;12:638003 [PMID: 33796089]
  202. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6590-5 [PMID: 18445655]
  203. Adv Mater. 2019 Mar;31(12):e1806727 [PMID: 30687975]
  204. Chem Mater. 2023 Jan 24;35(2):359-363 [PMID: 37799624]
  205. Chem Soc Rev. 2025 Jan 20;54(2):827-897 [PMID: 39618201]
  206. Small. 2020 Oct;16(41):e2002733 [PMID: 32945130]
  207. Colloids Surf B Biointerfaces. 2015 Nov 1;135:27-34 [PMID: 26241913]
  208. ACS Synth Biol. 2019 Jan 18;8(1):1-15 [PMID: 30576101]
  209. Nano Lett. 2024 May 22;24(20):6092-6101 [PMID: 38728297]
  210. Sci China Life Sci. 2023 Aug;66(8):1742-1785 [PMID: 36753021]
  211. Toxicol Appl Pharmacol. 2016 May 15;299:112-24 [PMID: 26724381]
  212. Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):1951-1961 [PMID: 31932441]
  213. Adv Mater. 2021 Aug;33(32):e2007768 [PMID: 34117805]
  214. Angew Chem Int Ed Engl. 2009;48(15):2759-63 [PMID: 19283813]
  215. Small. 2024 Feb;20(7):e2307111 [PMID: 37806755]
  216. Adv Mater. 2023 Apr;35(17):e2209692 [PMID: 36780890]
  217. ACS Appl Mater Interfaces. 2024 Oct 30;16(43):58072-58099 [PMID: 39432384]
  218. Adv Sci (Weinh). 2024 May;11(17):e2309271 [PMID: 38368258]
  219. ACS Nano. 2022 Oct 25;16(10):15627-15652 [PMID: 36121682]
  220. Nature. 2018 Jan 11;553(7687):217-221 [PMID: 29258297]
  221. Adv Sci (Weinh). 2025 Jan;12(4):e2413408 [PMID: 39639737]
  222. Adv Mater. 2021 Oct;33(39):e2103128 [PMID: 34350648]
  223. Nat Biotechnol. 2018 Mar;36(3):258-264 [PMID: 29431737]
  224. Adv Healthc Mater. 2024 May;13(12):e2302902 [PMID: 38199238]
  225. Adv Drug Deliv Rev. 2017 Jun 1;115:57-81 [PMID: 28412324]
  226. Nature. 2018 Jul;559(7715):547-555 [PMID: 30046072]
  227. Int J Nanomedicine. 2014 Jan 15;9:467-83 [PMID: 24531078]
  228. Small. 2021 Aug;17(31):e2100578 [PMID: 34190401]
  229. Int J Pharm. 2015 Oct 15;494(1):180-94 [PMID: 26278489]
  230. Sci Adv. 2022 Jul 15;8(28):eabn5315 [PMID: 35857507]
  231. BMJ. 2022 May 4;377:e069116 [PMID: 35508321]
  232. Science. 1975 Oct 24;190(4212):377-9 [PMID: 170679]
  233. 3 Biotech. 2022 Feb;12(2):41 [PMID: 35070631]
  234. BMC Bioinformatics. 2015 Aug 19;16:263 [PMID: 26286552]
  235. Cell. 2013 Sep 12;154(6):1380-9 [PMID: 23992846]
  236. Nat Rev Microbiol. 2014 May;12(5):381-90 [PMID: 24686414]
  237. Chem Soc Rev. 2013 Feb 7;42(3):1236-50 [PMID: 23175134]
  238. Chem Soc Rev. 2016 Jul 25;45(15):4074-126 [PMID: 27152673]
  239. Nanotheranostics. 2023 Mar 5;7(3):236-257 [PMID: 37064613]
  240. Front Plant Sci. 2015 Nov 10;6:984 [PMID: 26617624]
  241. Nat Commun. 2022 Oct 14;13(1):6073 [PMID: 36241613]
  242. J Microbiol Methods. 2019 Apr;159:18-25 [PMID: 30797020]
  243. Curr Diabetes Rev. 2020;16(8):807-819 [PMID: 31886753]
  244. Nat Biomed Eng. 2021 Sep;5(9):998-1007 [PMID: 33230304]

Grants

  1. 52372240/National Natural Science Foundation of China
  2. 2021YFA0910500/National Key Research and Development Program of China

MeSH Term

Humans
Nanostructures
Drug Delivery Systems
Nanotechnology
Synthetic Biology
Animals
Journal Article Review

Word Cloud

Created with Highcharts 10.0.0nanomaterialsbiologysyntheticdrugdeliveryengineeredreviewtargetedSyntheticnanotechnologytransformativefundamentalSynBioNanoDesignbiologicalsystemsmaterialscurrentdesigncircuitrychallengesfusionrepresentapproachpromotingclinicalbiomedicalsciencedevelopmentreimagineddynamicprogrammableyieldemergingspecificfunctionalitieselucidatescomprehensiveexaminationbiology'spivotalroleadvancingbeginsexploringsynergyhighlightslandscapeapplicationsSubsequentlydiscussesnovelinformedprinciplesfocusingexpoundingtoolspotentialdevelopingadvancedAfterwardresearchadvancesinnovativesystematicallysummarizedemphasizingintegrationgeneticprogramnanomaterialresponsesFurthermoreweaknessesopportunitiesprospectivedirectionsethicalsocietalimplicationselucidatedFinallysummarizesimpactmaydrug-deliverytechnologiesfutureSynBioNanoDesign:pioneeringEngineeredGeneticNanobiotechnologyPersonalizedmedicineRegulatoryTargeted

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