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Molecules (Basel, Switzerland)
Mar 06, 2025;30 (5):

Botanical Flavonoids: Efficacy, Absorption, Metabolism and Advanced Pharmaceutical Technology for Improving Bioavailability.

Lei Hu, Yiqing Luo, Jiaxin Yang, Chunsong Cheng
Author Information
  1. Lei Hu: Jiangxi Key Laboratory for Sustainable Utilization of Chinese Materia Medica Resources, Lushan Botanical Garden, Chinese Academy of Sciences, Jiujiang 332900, China. ORCID
  2. Yiqing Luo: Jiangxi Key Laboratory for Sustainable Utilization of Chinese Materia Medica Resources, Lushan Botanical Garden, Chinese Academy of Sciences, Jiujiang 332900, China.
  3. Jiaxin Yang: Jiangxi Key Laboratory for Sustainable Utilization of Chinese Materia Medica Resources, Lushan Botanical Garden, Chinese Academy of Sciences, Jiujiang 332900, China.
  4. Chunsong Cheng: Jiangxi Key Laboratory for Sustainable Utilization of Chinese Materia Medica Resources, Lushan Botanical Garden, Chinese Academy of Sciences, Jiujiang 332900, China. ORCID
PMID: 40076406 DOI: 10.3390/molecules30051184

Abstract

Flavonoids represent a class of natural plant secondary metabolites with multiple activities including antioxidant, antitumor, anti-inflammatory, and antimicrobial properties. However, due to their structural characteristics, they often exhibit low bioavailability in vivo. In this review, we focus on the in vivo study of Flavonoids, particularly the effects of gut microbiome on Flavonoids, including common modifications such as methylation, acetylation, and dehydroxylation, etc. These modifications aim to change the structural characteristics of the original substances to enhance absorption and bioavailability. In order to improve the bioavailability of Flavonoids, we discuss two feasible methods, namely dosage form modification and chemical modification, and hope that these approaches will offer new insights into the application of Flavonoids for human health. In this article, we also introduce the types, plant sources, and efficacy of Flavonoids. In conclusion, this is a comprehensive review on how to improve the bioavailability of Flavonoids.

Keywords

bioavailability efficacy flavonoids in vivo study modification

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Grants

  1. No.82260746/National Natural Science Foundation of China
  2. jxsq2023101038/Jiangxi Province Double Thousand Talent-Leader of Natural Science Project
  3. 2022BCJ25027 & 2023BBG70014/Jiangxi Province Urgently Overseas Talent Project
  4. S2024KXJJ0001/Natural Science Foundation of Jiujiang

MeSH Term

Flavonoids
Biological Availability
Humans
Gastrointestinal Microbiome
Animals
Technology, Pharmaceutical
Antioxidants

Chemicals

Flavonoids
Antioxidants
Journal Article Review

Word Cloud

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