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Molecules (Basel, Switzerland)
Mar 07, 2025;30 (6):

Integrated Biological and Chemical Investigation of Indonesian Marine Organisms Targeting Anti-Quorum-Sensing, Anti-Biofilm, Anti-Biofouling, and Anti-Biocorrosion Activities.

Novriyandi Hanif, Jihan Azmi Miftah, Henny Dwi Yanti, Emmanuel Tope Oluwabusola, Vira Amanda Zahra, Nurul Farhana Salleh, Binu Kundukad, Lik Tong Tan, Nicole J de Voogd, Nisa Rachmania, Marcel Jaspars, Staffan Kjelleberg, Dedi Noviendri, Anggia Murni, Junichi Tanaka
Author Information
  1. Novriyandi Hanif: Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia. ORCID
  2. Jihan Azmi Miftah: Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia. ORCID
  3. Henny Dwi Yanti: Tropical Biopharmaca Research Center, IPB University, Bogor 16128, Indonesia. ORCID
  4. Emmanuel Tope Oluwabusola: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3FX, UK. ORCID
  5. Vira Amanda Zahra: Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia. ORCID
  6. Nurul Farhana Salleh: Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore 637616, Singapore. ORCID
  7. Binu Kundukad: Singapore Center for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, 60 Nanyang Drive, SBS-01N-27, Singapore 637551, Singapore. ORCID
  8. Lik Tong Tan: Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore 637616, Singapore. ORCID
  9. Nicole J de Voogd: Naturalis Biodiversity Center, P.O. Box 9517, 2300 RA Leiden, The Netherlands. ORCID
  10. Nisa Rachmania: Department of Biology, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia. ORCID
  11. Marcel Jaspars: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3FX, UK. ORCID
  12. Staffan Kjelleberg: Singapore Center for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, 60 Nanyang Drive, SBS-01N-27, Singapore 637551, Singapore. ORCID
  13. Dedi Noviendri: Research Center for Pharmaceutical Ingredients and Traditional Medicine, BRIN Cibinong-Bogor, Bogor 16911, Indonesia. ORCID
  14. Anggia Murni: Tropical Biopharmaca Research Center, IPB University, Bogor 16128, Indonesia. ORCID
  15. Junichi Tanaka: Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Okinawa 903-0213, Japan. ORCID
PMID: 40141983 DOI: 10.3390/molecules30061202

Abstract

Microorganisms play a significant role in biofouling and biocorrosion within the maritime industry. Addressing these challenges requires an innovative and integrated approach utilizing marine natural products with beneficial properties. A comprehensive screening of 173 non-toxic EtOAc and H���O extracts derived from diverse marine organisms collected in Indonesian waters was conducted using a robust panel of assays. These included antimicrobial tests and classical biosurfactant assays (drop collapse and oil displacement), as well as anti-quorum-sensing (QS) and anti-biofilm assays. These screening efforts identified five active extracts with promising activities. Among these, EtOAc extracts of the marine tunicate cf. (0159-22e) and the marine sponge (0194-24c) demonstrated significant anti-biofouling activity against and anti-biocorrosion performance (mpy 10.70 �� 0.70 for cf. ; 7.87 �� 0.86 for 13.60 �� 1.70 for positive control Tetracorr CI-2915). Further chemical analyses of the active extracts, including LC-HR-MS/MS, MS-based molecular networking, and chemoinformatics, revealed the presence of both known and new bioactive compounds. These included tambjamines and polybrominated diphenyl ethers (PBDEs), which are likely contributors to the observed bioactivities. Subsequent investigations uncovered new anti-QS and anti-biofilm properties in synthetic and natural PBDEs - previously derived from . Among these, exhibited the most potent anti-QS activity, with an IC value of 15 ��M, while significantly reduced biofilm formation at a concentration of 1 ��M. This study highlights the potential of marine-derived compounds in addressing biofouling and biocorrosion challenges in a sustainable and effective manner.

Keywords

Lamellodysidea herbacea NMR Sigilina cf. signifera anti-biocorrosion anti-biofilm anti-biofouling anti-quorum sensing molecular networking

References

  1. J Nat Prod. 1995 Sep;58(9):1384-91 [PMID: 7494145]
  2. Bioorg Med Chem. 2010 Feb;18(3):1297-311 [PMID: 20061160]
  3. J Nat Prod. 1996 Nov;59(11):1102-3 [PMID: 8946753]
  4. Mar Drugs. 2024 Jun 24;22(7): [PMID: 39057400]
  5. J Nat Prod. 2009 Mar 27;72(3):443-9 [PMID: 19323567]
  6. J Chem Inf Model. 2023 Jun 26;63(12):3925-3940 [PMID: 37285197]
  7. Microb Drug Resist. 2016 Dec;22(8):638-645 [PMID: 27031025]
  8. Pathogens. 2024 Feb 05;13(2): [PMID: 38392883]
  9. Nat Biotechnol. 2016 Aug 9;34(8):828-837 [PMID: 27504778]
  10. Antibiotics (Basel). 2019 Jun 12;8(2): [PMID: 31212792]
  11. Biofouling. 2008;24(3):201-8 [PMID: 18373284]
  12. Nat Prod Rep. 2011 Feb;28(2):400-10 [PMID: 21082120]
  13. Biofouling. 2015;31(1):101-22 [PMID: 25622074]
  14. Mar Drugs. 2016 Oct 27;14(11): [PMID: 27801777]
  15. Mycopathologia. 2021 Dec;186(6):819-832 [PMID: 34564785]
  16. BMC Biotechnol. 2002 Sep 23;2:17 [PMID: 12270067]
  17. Nat Biotechnol. 2012 Oct;30(10):918-20 [PMID: 23051804]
  18. Arch Microbiol. 2023 Oct 31;205(12):364 [PMID: 37906317]
  19. Mar Drugs. 2020 May 21;18(5): [PMID: 32455754]
  20. J Biol Chem. 2007 May 4;282(18):13592-600 [PMID: 17363368]
  21. Mar Biotechnol (NY). 2009 Mar-Apr;11(2):188-98 [PMID: 18690486]
  22. J Nat Prod. 2007 Mar;70(3):432-5 [PMID: 17311456]
  23. Front Microbiol. 2019 Jul 24;10:1715 [PMID: 31396200]
  24. Mar Drugs. 2020 Jun 23;18(6): [PMID: 32585891]
  25. J Nat Prod. 2013 Mar 22;76(3):420-4 [PMID: 23410078]
  26. J Nat Prod. 2009 Aug;72(8):1552-4 [PMID: 19670881]
  27. J Basic Microbiol. 2020 Sep;60(9):799-808 [PMID: 32598075]
  28. Biofouling. 2020 Nov;36(10):1210-1226 [PMID: 33401982]
  29. Z Naturforsch C J Biosci. 2006 Jul-Aug;61(7-8):472-6 [PMID: 16989304]
  30. J Nat Prod. 2005 Jan;68(1):118-21 [PMID: 15679333]
  31. J Nat Prod. 2008 Feb;71(2):262-4 [PMID: 18198840]
  32. Nat Biotechnol. 2023 Apr;41(4):447-449 [PMID: 36859716]
  33. Genome Res. 2003 Nov;13(11):2498-504 [PMID: 14597658]
  34. J Nat Prod. 2021 Mar 26;84(3):790-796 [PMID: 33371682]
  35. Appl Environ Microbiol. 1998 Jun;64(6):2240-6 [PMID: 9603842]
  36. Int J Mol Sci. 2020 Aug 23;21(17): [PMID: 32842499]
  37. Nat Prod Rep. 2004 Feb;21(1):94-104 [PMID: 15039837]
  38. Molecules. 2021 Oct 20;26(21): [PMID: 34770740]
  39. J Nat Prod. 2012 Apr 27;75(4):774-8 [PMID: 22360686]
  40. Microbiology (Reading). 2002 Jan;148(Pt 1):87-102 [PMID: 11782502]
  41. J Nat Prod. 1997 Dec;60(12):1313-6 [PMID: 9463111]
  42. J Nat Prod. 2004 Mar;67(3):472-4 [PMID: 15043436]
  43. Nat Prod Rep. 2019 Mar 20;36(3):410-429 [PMID: 30264841]
  44. Acc Chem Res. 2024 Feb 6;57(3):399-412 [PMID: 38277792]
  45. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2668-70 [PMID: 20227875]
  46. Nucleic Acids Res. 2024 Jul 5;52(W1):W324-W332 [PMID: 38686803]
  47. Molecules. 2024 Nov 10;29(22): [PMID: 39598696]
  48. Int J Mol Sci. 2019 Sep 30;20(19): [PMID: 31574976]
  49. Mar Drugs. 2019 Jun 19;17(6): [PMID: 31248122]

Grants

  1. 106/IV/KS/11/2023, 41644/IT3/PT.01.03/P/B/2023, 1/PEE-2/PPK-DFRI/2022, and 7197/IT3.L1PT.01./Indonesia Endowment Fund for Education Agency (LPDP) and National Research and Innovation Agency (BRIN) of the Republic of Indonesia

MeSH Term

Biofilms
Biofouling
Indonesia
Animals
Aquatic Organisms
Quorum Sensing
Biological Products
Urochordata
Porifera
Microbial Sensitivity Tests

Chemicals

Biological Products
Journal Article

Word Cloud

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