The aim of this article is to perform a review of the literature on the current status of shoulder arthroplasty in people with hemophilia (PWH). A search was conducted in PubMed on December 8, 2024, using the keywords "hemophilia" and "shoulder arthroplasty." To date only 4 articles (84 shoulder arthroplasties) in PWH have been published. A recent study with level 3 of evidence has found that five-year implant survival was similar in PWH (97.3%) than in matched controls (95.2%) suggesting that total shoulder arthroplasty (TSA) survivorship endures lasting and might be proposed to PWH. However, the high risks of both 90-day bleeding complication and venous thromboembolism (VTE) in PWH stressed the special dares of scrupulously weighing factor replacement and VTE prophylaxis pre-, intra-, and postoperatively on an individual patient basis with cautious hematologist coordination.
