Bixia Tang

Senior Engineer

Software & System Development

Email: tangbx (AT) big.ac.cn

Tel: +86 (10) 8409-7340

PROFESSIONAL EXPERIENCE

·        Senior Engineer, Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation (CNCB), China, 2023.06−Present

·        Engineer, Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation (CNCB), China, 2011.08−2023.05

·        Assistant Engineer, Beijing Institute of Genomics, Chinese Academy of Sciences, China, 2009.07−2011.07

EDUCATION

         ·        Ph.D. in Bioinformatics, Beijing Institute of Genomics, Chinese Academy of Sciences (CAS), China, 2013-2019

         ·        MS in Computer Science and Technology, Beijing University of Posts and Telecommunications, China, 2006-2009

         ·        BS in Computer Science and Technology, China University of Petroleum-Beijing, China, 2002-2006

RESEARCH INTERESTS

·        Big Data Integration and Analytics

·        Data Visualization

·        Artificial intelligence

PROJECTS & RESOURCES

·         GenBase (Data repository for efficient nucleotide sequence archiving, searching, and sharing)

·         iDog 2.0 & iDog 1.0 (an integrated multi-omics resource for canids, China's Top Ten Bioinformatics Databases of 2019)

·         BioKA (a curated biomarker knowledgebase for animals)

·         HGD (a data portal of homologous genes across multiple species)

·         CGB (a genome browser for SARS-CoV-2)

·         GVM 1.0 & GVM 2.0 (a public data repository of genome variations)

·         ChickenSD (A variation database for chicken)

·        Delta & Delta.AR & Delta.EPI (3D genome visualization and analysis platform)

·        3CDB (Chromosome Conformation Capture Database)

SOFTWARE COPYRIGHT

·        面向生物组学大数据计算的云平台系统及方法, 发明专利，201610413045

·         基因序列数据库系统 [简称：GenBase] V1.0, 2024SR0524818

·         基因序列数据整合软件 [简称：Multif2f] V1.0，2024SR0524464

·         动物生物标志物数据库系统 [简称：BioKA] V1.0, 2024SR0525761

·         同源基因数据库v1.0, 2023SR0619910

·         基因组变异数据库系统V2.0, 2021SR1324908

·         DogPD: 犬科动物表型数据库系统V1.0，2020SR0047831

·         犬科动物基因组数据库系统V1.0，2020SR0054838

·         GVM变异数据库系统V1.0，2019SR0347243

·         生物信息云计算平台V1.0，2017SR097989

·         单核苷酸多态性的可视化展示系统V1.0，2017SR097943

·         重亚硫酸盐测序数据分析平台V1.0，2014SR057786

·         wapRNA:基于高通量测序的在线RNA分析软件V1.0，2012SR083283

FUNDING

·        Key technical talents of the Chinese Academy of Sciences (No. 2023000007) , 2023.01-2025.12

·        National Natural Science Foundation of China (Grant No. 32100506): Research on knowledge graph of dog genotype-phenotype using the semantic web approach, 2022.01-2024.12

PUBLICATIONS

            1.      Bu C#, Zheng X#, Zhao X#, Xu T#, Bai X#, Jia Y, Chen M, Hao L, Xiao J, Zhang Z, Zhao W, Tang B*, Bao Y*. GenBase: A Nucleotide Sequence Database. Genomics Proteomics Bioinformatics. 2024 Sep 13;22(3): qzae047. 

            2.      Liu Y#, Wang Y#, Sun J#, Kong D#, Zhou B#, Ding M, Meng Y, Duan G, Cui Y, Fan Z, Zhang YP, Zhao W*, Tang B*. iDog: a multi-omics resource for canids study. Nucleic Acids Res. 2024 Nov 11: gkae1031.

            3.      Cui Y#, Tang B#, Wu G, Li L, Zhang X, Du Z, Zhao W*. Classification of Dog Breeds Using Convolutional Neural Network Models and Support Vector Machine. Bioengineering (Basel). 2024 Nov 17;11(11): 1157. 

            4.      Wu G, Jin E, Sun Y, Tang B*, Zhao W*. Deep Attention Fusion Hashing (DAFH) Model for Medical Image Retrieval. Bioengineering (Basel). 2024 Jul 2;11(7):673.

            5.      Wang Y#, Lin Y#, Wu S#, Sun J, Meng Y, Jin E, Kong D, Duan G, Bei S, Fan Z, Wu G, Hao L, Song S, Tang B*, Zhao W*. BioKA: a curated and integrated biomarker knowledgebase for animals. Nucleic Acids Res. 2024 Jan 5;52(D1): D1121-D1130. 

            6.      Tang B# as co-first author in CNCB-NGDC Members & Partners. Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2024. Nucleic Acids Res. 2024 Jan 5;52(D1): D18-D32. 

            7.      Tang B# as co-first author in CNCB-NGDC Members & Partners. Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023.  Nucleic Acids Res. 2023 Jan 6;51(D1): D18-D28.

           8.      Duan G#, Wu G#, Chen X, Tian D, Li Z, Sun Y, Du Z, Hao L, Song S, Gao Y, Xiao J, Zhang Z, Bao Y, Tang B*, Zhao W*. HGD: an integrated homologous gene database across multiple species. Nucleic Acids Res. 2023 Jan 6;51(D1): D994-D1002

          9.       Zhang Y,  Wang H, Liu J, Li J, Zhang Q*, Tang B*, Zhang Z*. Delta.EPI: a probabilistic voting-based enhancer-promoter      interaction prediction platform. J Genet Genomics. 2023 Jul;50(7):519-527. 

         10.     Liu X#,  Tian D#, Li C#, Tang B, Wang Z, Zhang R, Pan Y, Wang Y,  Zou D, Zhang Z*, Song S*. GWAS Atlas: an updated      knowledgebase integrating more curated associations in plants and animals.      Nucleic Acids Res. 2023 Jan 6;51(D1):D969-D976. 

         11.   Tang B# as co-first author in CNCB-NGDC  Members and Partners. Database Resources of the National Genomics Data      Center, China National Center for Bioinformation in 2022. Nucleic Acids      Res. 2022 Jan 7;50(D1): D27-D38. 

         12.    Yu D^#, Yang X^#, Tang B^#, Pan YH^#, Yang J^#, Duan G^#, Zhu J, Hao ZQ, Mu H, Dai L, Hu W, Zhang M, Cui Y, Jin T, Li CP, Ma L, Su X, Zhang G*, Zhao W*, Li H*. Coronavirus GenBrowser for monitoring the transmission and evolution of SARS-CoV-2. Brief Bioinform. 2022 Mar 10;23(2): bbab583.

         13.   Tang B# as co-first author in CNCB-NGDC Members and Partners. Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021. Nucleic Acids Res. 2021 Jan 8;49(D1): D18-D28.

         14.    Tang B#, Li X, Li G, Tian D, Li F, Zhang Z*. Delta.AR: An augmented reality-based visualization platform for 3D genome. Innovation (Camb). 2021 Aug 3;2(3):100149.

         15.    Li C#, Tian D#, Tang B#, Liu X#, Teng X#, Zhao W, Zhang Z*, Song S*. Genome Variation Map: a worldwide collection of genome variations across multiple species. Nucleic Acids Res. 2021 Jan 8;49(D1): D1186-D1191.

         16.    Chen T, Chen X, Zhang S, Zhu J, Tang B, Wang A, Dong L, Zhang Z, Yu C, Sun Y, Chi L, Chen H, Zhai S, Sun Y, Lan L, Zhang X, Xiao J, Bao Y, Wang Y, Zhang Z, Zhao W. The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types. Genomics Proteomics Bioinformatics. 2021 Aug;19(4):578-583. 

         17.   Tang B# as co-first author in National Genomics Data Center Members and Partners. Database Resources of the National Genomics Data Center in 2020. Nucleic Acids Res. 2020 Jan 8;48(D1): D24-D33. 

         18.     Zhao WM, Song SH, Chen ML, Zou D, Ma LN, Ma YK, Li RJ, Hao LL, Li CP, Tian DM, Tang BX, Wang YQ, Zhu JW, Chen HX, Zhang Z, Xue YB, Bao YM. The 2019 novel coronavirus resource. Yi Chuan. 2020 Feb 20;42(2):212-221. 

         19.     Tian D#, Wang P#, Tang B#, Teng X, Li C, Liu X, Zou D, Song S*, Zhang Z*. GWAS Atlas: a curated resource of genome-wide variant-trait associations in plants and animals. Nucleic Acids Res. 2020 Jan 8;48(D1):D927-D932.

         20.     Gong Z, Zhu JW, Li CP, Jiang S, Ma LN, Tang BX, Zou D, Chen ML, Sun YB, Song SH, Zhang Z, Xiao JF, Xue YB, Bao YM, Du ZL, Zhao WM. An online coronavirus analysis platform from the National Genomics Data Center. Zool Res. 2020 Nov 18;41(6):705-708.

         21.     Tang B# as co-first author in BIG Data Center Members. Database Resources of the BIG Data Center in 2019. Nucleic Acids Res. 2019 Jan 8;47(D1):D8-D14. 

         22.     Yu D#, Dong L#, Yan F#, Mu H#, Tang B#, Yang X, Zeng T, Zhou Q, Gao F, Wang Z, Hao Z, Kang H, Zheng Y, Huang H, Wei Y, Pan W, Xu Y, Zhu J, Zhao S, Wang C, Wang P, Dai L, Li M, Lan L, Wang Y, Chen H, Li YX, Fu YX, Shao Z, Bao Y, Zhao F, Chen LN, Zhang GQ*, Zhao W*, Li H*. eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses. Natl Sci Rev. 2019 Oct;6(5):867-869. 

        23.     Song S#, Tian D#, Li C#, Tang B#, Dong L, Xiao J, Bao Y, Zhao W, He H, Zhang Z*. Genome Variation Map: a data repository of genome variations in BIG Data Center. Nucleic Acids Res. 2018 Jan 4;46(D1): D944-D949.

       24.     Tang B# as co-first author in BIG Data Center Members. Database Resources of the BIG Data Center in 2018. Nucleic Acids Res. 2018 Jan 4;46(D1): D14-D20. 

       25.     Tang B#, Zhou Q#, Dong L#, Li W, Zhang X, Lan L, Zhai S, Xiao J, Zhang Z, Bao Y, Zhang YP, Wang GD*, Zhao W*. iDog: an integrated resource for domestic dogs and wild canids. Nucleic Acids Res. 2019 Jan 8;47(D1): D793-D800

       26.     Wang Y, Song F, Zhu J, Zhang S, Yang Y, Chen T, Tang B, Dong L, Ding N, Zhang Q, Bai Z, Dong X, Chen H, Sun M, Zhai S, Sun Y, Yu L, Lan L, Xiao J, Fang X, Lei H, Zhang Z, Zhao W. GSA: Genome Sequence Archive<sup/>. Genomics Proteomics Bioinformatics. 2017 Feb;15(1):14-18. 

       27.     Tang B# as co-first author in BIG Data Center Members. The BIG Data Center: from deposition to integration to translation. Nucleic Acids Res. 2017 Jan 4;45(D1): D18-D24.

       28.     Yun X, Xia L, Tang B, Zhang H, Li F, Zhang Z. 3CDB: a manually curated database of chromosome conformation capture data. Database (Oxford). 2016 Apr 14;2016: baw044. 

       29.     Luo H, Zhao W, Wang Y, Xia Y, Wu X, Zhang L, Tang B, Zhu J, Fang L, Du Z, Bekele WA, Tai S, Jordan DR, Godwin ID, Snowdon RJ, Mace ES, Jing HC, Luo J: SorGSD: a sorghum genome SNP database. Biotechnol Biofuels 2016, 9:6.  

       30.     Bai B#, Zhao WM#, Tang BX#, Wang YQ, Wang L, Zhang Z, Yang HC, Liu YH, Zhu JW, Irwin DM, Wang GD*, Zhang YP*. DoGSD: the dog and wolf genome SNP database. Nucleic Acids Research 2015, 43(D1): D777-D783.  

       31.    Tang B#, Wang Y, Zhu J, Zhao W*. Web resources for model organism studies. Genomics, proteomics & bioinformatics 2015, 13(1):64-68.  

       32.     Liang F#, Tang B#, Wang Y, Wang J, Yu C, Chen X, Zhu J, Yan J, Zhao W*, Li R*. WBSA: web service for bisulfite sequencing data analysis. PloS one 2014, 9(1): e86707.

       33.    Zhao W^#, Liu W^#, Tian D^#, Tang B^#, Wang Y, Yu C, Li R, Ling Y, Wu J, Song S*, Hu S*. wapRNA: a web-based application for the processing of RNA sequences. Bioinformatics 2011, 27(21):3076-3077.