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Zhang Zhang
Zhang Zhang

Professor

Email: zhangzhang (AT) big.ac.cn

Tel: +86 (10) 8409-7261

Chinese Name: 章张  [Google Scholar, h-index=53, as of October 2024; Academic Genealogy; ORCID: 0000-0001-6603-5060] 

BIOGRAPHY

Dr. Zhang Zhang is a Distinguished Professor of Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS) & China National Center for Bioinformation (CNCB), and acts as Associate Director of the National Genomics Data Center (NGDC), which is part of BIG & CNCB. He obtained his PhD degree in Computer Science from Institute of Computing Technology, CAS in 2007, with a bioinformatics joint program with BIG, under the supervision of Jun Yu. Prior to joining BIG, he worked as Postdoctoral Associate at Yale University (advised by Jeffrey P. Townsend) in United States from 2007~2009 and Research Scientist at King Abdullah University of Science and Technology (advised by Vladimir B. Bajic) in Saudi Arabia from 2009~2011.

In 2011, Dr. Zhang was appointed as Professor in the CAS 100-Talent Program by BIG. Considering the critical importance of multi-omics data, he focuses on biological data integration & curation and development of multi-omics data resources and new algorithms & tools. In 2016, Dr. Zhang co-founded the BIG Data Center and served as Executive Director responsible for the center development. In this role, he led the center team to construct a family of database resources and computational methods and to provide a range of data services in support of worldwide research activities. Importantly, he led the center development by setting the organizational structure and directions, establishing the scientific advisory board composed with global field experts, and building interactions and collaborations with worldwide institutions to maximize the scope of data sharing. Based on the BIG Data Center, NGDC and CNCB were officially founded in 2019. Over the past several years, Dr. Zhang developed more than forty database resources and computational tools, organized a series of scientific conferences for promotion of computational biology & bioinformatics domestically and internationally, and raised the general awareness of significant value of database resources as a fundamental infrastructure for biomedical research.

Dr. Zhang published more than 140 papers and his research achievements have been selected in the "Top 10 Advances in Bioinformatics in China". He was an Executive Committee member of the International Society for Biocuration (2015-2018) and now serves as Asian Regional Editor for Briefings in Bioinformatics (2017-) and Associate Editor-in-Chief for Genomics Proteomics & Bioinformatics (2012-). Towards a new paradigm from data to theory, he recently works on theoretical biology with new algorithms, models and laws for deciphering basic principles of life.

PROFESSIONAL EXPERIENCE

  • Head of Department of Data Resources, China National Center for Bioinformation, China, 2024 - Present

  • Associate Director of National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation, China, 2020 - Present

  • Executive Director of BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, China, 2016 - 2020

  • Professor, University of Chinese Academy of Sciences (UCAS), China, 2016 - Present

  • Professor in the CAS 100-Talent Program, Beijing Institute of Genomics, Chinese Academy of Sciences, China, 2011 - Present

  • Research Scientist, King Abdullah University of Science and Technology, Kingdom of Saudi Arabia, 2009 - 2011

  • Postdoctoral Associate, Yale University, United States of America, 2007 - 2009

EDUCATION

  • PhD in Computer Science (a bioinformatics joint program with BIG), Institute of Computing Technology, Chinese Academy of Sciences, China, 2007

  • MS in Computer Science, Nanjing University of Science and Technology, China, 2004

  • BS in Computer Science, Ningxia University, China, 2002

HONORS & AWARDS

  • 2024年国家杰出青年科学基金获得者（National Science Fund for Distinguished Young Scholars 2024）

  • 2023年中国生物信息学十大进展（Top 10 Advances in Bioinformatics in China 2023）

  • 2023年度“全球前2%顶尖科学家”（World Top 2% Scientists 2023）

  • 2023年度中国科学院大学校级“本科生优秀课程” - 基因组学（2023 UCAS University-Level Excellent Undergraduate Course - Genomics）

  • 2022年中国生物信息学十大进展（Top 10 Advances in Bioinformatics in China 2022）

  • 2022年度“全球前2%顶尖科学家”（World Top 2% Scientists 2022）

  • 2022年度中国科学院大学院级“本科生优秀课程” - 基因组学（2022 UCAS College-Level Excellent Undergraduate Course - Genomics）

  • 2022年中国科学院特聘研究员（Distinguished Professor of Chinese Academy of Sciences, August 2022）

  • 2021年中国生物信息学十大进展（Top 10 Advances in Bioinformatics in China 2021）

  • 2021年度“全球前2%顶尖科学家”（World's Top 2% Scientists 2021）

  • 2021年中国科学院大学-BHPB导师科研奖（UCAS-BHPB Excellent Supervisor Award, November 2021）

  • 2020年中国生物信息学十大进展（Top 10 Advances in Bioinformatics in China 2020）

  • 2020年中国科学院大学“领雁金奖”引航奖（UCAS Lingyan Golden Award, September 2020）

  • 2019年中国生物信息学十大数据库（Top 10 Databases in Bioinformatics in China 2019）

  • 2019年国家“万人计划”青年拔尖人才（National Ten Thousand Talent Program for Young Top-notch Talent, February 2019）

  • 2018年中国生物信息学十大进展（Top 10 Advances in Bioinformatics in China 2018）

  • 2018年“长江学者奖励计划”青年学者（Chang Jiang Young Scholar, 2018）

  • 2018年中国科学院大学-BHPB导师科研奖（UCAS-BHPB Excellent Supervisor Award, September 2018）

  • 2017年中国科学院北京基因组研究所特聘研究员（Distinguished Professor of Beijing Institute of Genomics, September 2017）

  • 2017年中国科学院“百人计划”终期评估优秀奖（Excellence Award in the Final Evaluation of the CAS 100-Talent Program, August 2017）

AWARDS OF SUPERVISED STUDENTS

  • 2023年中国科学院朱李月华奖学金 - 李昭 (Zhao Li, 2023 CAS Pollyanna Chu Scholarship)

  • 2022年博士研究生国家奖学金 - 刘晓楠 (Xiaonan Liu, 2022 National Scholarship for Doctoral Students)

  • 2022年度中国科学院院长优秀奖 - 滕徐菲 (Xufei Teng, 2022 CAS President Execellent Award)

  • 2021年中国科学院-必和必拓BHPB奖 - 滕徐菲 (Xufei Teng, 2021 UCAS-BHPB Award)

  • 2021年博士研究生国家奖学金 - 李昭 (Zhao Li, 2021 National Scholarship for Doctoral Students)

  • 2021年硕士研究生国家奖学金 - 朱彤彤 (Tongtong Zhu, 2021 National Scholarship for Master Students)

  • 2021年北京市普通高等学校优秀毕业生 - 刘琳 (Lin Liu, 2021 Execellent Graduate of Higher Education Universities in Beijing)

  • 2020年博士研究生国家奖学金 - 刘琳 (Lin Liu, 2020 National Scholarship for Doctoral Students)

  • 2020年硕士研究生国家奖学金 - 张源笙 (Yuansheng Zhang, 2020 National Scholarship for Master Students)

  • 2019年北京市普通高等学校优秀毕业生 - 王佩 (Pei Wang, 2019 Execellent Graduate of Higher Education Universities in Beijing)

  • 2019年硕士研究生国家奖学金 - 王佩 (Pei Wang, 2019 National Scholarship for Master Students)

  • 2019年北京市普通高等学校优秀毕业生 - 桑健 (Jian Sang, 2019 Execellent Graduates of Higher Education Universities in Beijing)

  • 2018年博士研究生国家奖学金 - 桑健 (Jian Sang, 2018 National Scholarship for Doctoral Students)

  • 2018年硕士研究生国家奖学金 - 曹佳宝 (Jiabao Cao, 2018 National Scholarship for Master Students)

  • 2018年中国科学院-必和必拓BHPB奖 - 桑健 (Jian Sang, 2018 UCAS-BHPB Award)

致同学们：在你决定是否选择我做导师前，务必三思。我是一位非著名学者，因此招生有一个基本原则：你别太好，免得我耽误你；也别太差，免得你耽误我。我理解你在选择导师时的盲目性，但你是否真有兴趣去做数据库、算法、理论等基础研究工作。如果你之前没有努力学习、认真生活的实践，你来到我这里会感到很难过。千万不要送礼，实在想送，毕业后可参考新基石科研项目。研究生阶段，师生更多的是团队合作关系，自主内驱、积极主动、协同攻坚、有效沟通非常重要，否则研究生阶段难有收获。有些性格妨碍沟通：自甘平庸，过分轻狂......科研如翻山越岭，定力、耐力、体力都很重要，勇敢面对，坚持不懈，遇到挑战和失败依然乐观前行，没有人能随随便便成功，谁都不例外。最后，欢迎报考，有勇气才会有运气。放心，我可能不是你最好的选择，但肯定不是你最差的选择（全局最优很难，局部最优不易）。（─节选改编自中科院计算所贺思敏老师）

RESEARCH INTERESTS

  • Big Data Integration and Curation: construction of multi-omics databases and knowledgebases by big data integration and curation and development of new theory for biological big data commons and ecosystem, with particular focuses on public health and national strategic important species. 生物大数据整合审编与数据库系统研发：面向我国人口健康和重要战略生物资源，建立海量多组学数据资源体系，研发多层次组学数据库、信息库与知识库系统，发展生物大数据公共资源生态系统理论。

  • Computational Molecular Evolution: establishment of molecular evolutionary models and theories at the nucleotide and codon levels and development of new methods and tools for detecting national selection pressure. 计算分子进化与自然选择压力检测：发展分子序列在核苷酸和密码子水平上的演化新模型和新理论，研发自然选择压力检测新方法与新技术。

  • Computational Health Genomics: development of new methods and algorithms by associating omics data with health data and conducting integrative data analysis and deep mining via artificial intelligence and machine learning, with the aim to provide more effective ways for precision health and medical treatment for brain tumors, like glioma. 健康基因组数据智能深度挖掘：围绕人类脑胶质瘤等重大疾病，基于人工智能、机器学习、统计学习等多学科前沿交叉技术，研发面向精准医学的肿瘤多组学数据与健康数据的整合分析和深度挖掘的新方法与新技术。

TEACHING

  • Introduction to Omics (for graduates; in English)

  • Bioinformatics, Genomics, Big Data (for graduates; in Chinese)

  • Genomics (for undergraduates; in Chinese)

FEATURED PROJECTS & RESOURCES

ACADEMIC ACTIVITIES

PUBLICATIONS

  1. Zhang Z (2024) Expanding bioinformatics: Toward a paradigm shift from data to theory. Fundamental Research, 10.1016/j.fmre.2024.11.019.

  2. Zhang Z (2024) Laws of Genome Nucleotide Composition. Genomics Proteomics Bioinformatics, 22. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-39213341

  3. Chen M, Xia L, Tan X, Gao S, Wang S, Li M, Zhang Y, Xu T, Cheng Y, Chu Y, Hu S, Wu S and Zhang Z (2024) Seeing the unseen in characterizing RNA editome during rice endosperm development. Commun Biol, 7, 1314. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-39397073

  4. Li Q, Zhang Y, Luo S, Zhang Z, Oberg AL, Kozono DE, Lu H, Sarkaria JN, Ma L and Wang L (2024) Identify Non-mutational p53 Functional Deficiency in Human Cancers. Genomics Proteomics Bioinformatics, 10.1093/gpbjnl/qzae064. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-39325855 

  5. Tian D, Xu T, Kang H, Luo H, Wang Y, Chen M, Li R, Ma L, Wang Z, Hao L, Tang B, Zou D, Xiao J, Zhao W, Bao Y, Zhang Z and Song S (2024) Plant genomic resources at National Genomics Data Center: assisting in data-driven breeding applications. aBIOTECH, 5, 94-106. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-38576435

  6. CNCB-NGDC Members & Partners (2024) Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2024. Nucleic Acids Res, 52, D18-D32. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-38018256

  7. Li L, Li C, Li N, Zou D, Zhao W, Luo H, Xue Y, Zhang Z, Bao Y and Song S (2024) Machine Learning Early Detection of SARS-CoV-2 High-Risk Variants. Adv Sci (Weinh), 10.1002/advs.202405058, e2405058. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-39401400

  8. Zhao Y, Zhang Y, Li S, Tan S, Cao J, Wang HL, Luo J, Guo H, Zhang Z and Li Z (2024) Leaf Senescence Database v5.0: A Comprehensive Repository for Facilitating Plant Senescence Research. J Mol Biol, 436, 168530. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-38462130

  9. Gao X, Chen K, Xiong J, Zou D, Yang F, Ma Y, Jiang C, Gao X, Wang G, Gu S, Zhang P, Luo S, Huang K, Bao Y, Zhang Z, Ma L and Miao W (2024) The P10K database: a data portal for the protist 10 000 genomes project. Nucleic Acids Res, 52, D747-D755. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-37930867

  10. Cao Y, Tian D, Tang Z, Liu X, Hu W, Zhang Z and Song S (2024) OPIA: an open archive of plant images and related phenotypic traits. Nucleic Acids Res, 52, D1530-D1537. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-37930849

  11. Bu C, Zheng X, Zhao X, Xu T, Bai X, Jia Y, Chen M, Hao L, Xiao J, Zhang Z, Zhao W, Tang B and Bao Y (2024) GenBase: A Nucleotide Sequence Database. Genomics Proteomics Bioinformatics, 22. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-38913867

  12. Zhu T, Niu G, Zhang Y, Chen M, Li CY, Hao L and Zhang Z (2023) Host-mediated RNA editing in viruses. Biol Direct, 18, 12. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36978112

  13. Zhang Z, Hu S and Yu J (2023) Toward a New Paradigm of Genomics Research. Genomics, Proteomics & Bioinformatics, 21, 904-909. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-WOS:001186387600001

  14. Zhang M, Zong W, Zou D, Wang G, Zhao W, Yang F, Wu S, Zhang X, Guo X, Ma Y, Xiong Z, Zhang Z, Bao Y and Li R (2023) MethBank 4.0: an updated database of DNA methylation across a variety of species. Nucleic Acids Res, 51, D208-D216. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36318250

  15. Wang Z, Wang YW, Kasuga T, Lopez-Giraldez F, Zhang Y, Zhang Z, Wang Y, Dong C, Sil A, Trail F, Yarden O and Townsend JP (2023) Lineage-specific genes are clustered with HET-domain genes and respond to environmental and genetic manipulations regulating reproduction in Neurospora. PLoS Genet, 19, e1011019. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-37934795

  16. Pan S, Kang H, Liu X, Lin S, Yuan N, Zhang Z, Bao Y and Jia P (2023) Brain Catalog: a comprehensive resource for the genetic landscape of brain-related traits. Nucleic Acids Res, 51, D835-D844. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36243988

  17. Ma L, Zou D, Liu L, Shireen H, Abbasi AA, Bateman A, Xiao J, Zhao W, Bao Y and Zhang Z (2023) Database Commons: A Catalog of Worldwide Biological Databases. Genomics Proteomics Bioinformatics, 21, 1054-1058. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36572336

  18. Ma L and Zhang Z (2023) The contribution of databases towards understanding the universe of long non-coding RNAs. Nat Rev Mol Cell Biol, 24, 601-602. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-37147495

  19. Liu Y, Zhang Y, Liu X, Shen Y, Tian D, Yang X, Liu S, Ni L, Zhang Z, Song S and Tian Z (2023) SoyOmics: A deeply integrated database on soybean multi-omics. Mol Plant, 16, 794-797. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36950735

  20. Liu X, Tian D, Li C, Tang B, Wang Z, Zhang R, Pan Y, Wang Y, Zou D, Zhang Z and Song S (2023) GWAS Atlas: an updated knowledgebase integrating more curated associations in plants and animals. Nucleic Acids Res, 51, D969-D976. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36263826

  21. Li Z, Liu L, Feng C, Qin Y, Xiao J, Zhang Z and Ma L (2023) LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations. Nucleic Acids Res, 51, D186-D191. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36330950

  22. Li L, Xu B, Tian D, Wang A, Zhu J, Li C, Li N, Zhao W, Shi L, Xue Y, Zhang Z, Bao Y, Zhao W and Song S (2023) McAN: a novel computational algorithm and platform for constructing and visualizing haplotype networks. Brief Bioinform, 24. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-37170752

  23. Jiang S, Qian Q, Zhu T, Zong W, Shang Y, Jin T, Zhang Y, Chen M, Wu Z, Chu Y, Zhang R, Luo S, Jing W, Zou D, Bao Y, Xiao J and Zhang Z (2023) Cell Taxonomy: a curated repository of cell types with multifaceted characterization. Nucleic Acids Res, 51, D853-D860. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36161321

  24. Hua Z, Jiang C, Song S, Tian D, Chen Z, Jin Y, Zhao Y, Zhou J, Zhang Z, Huang L and Yuan Y (2023) Accurate identification of taxon-specific molecular markers in plants based on DNA signature sequence. Mol Ecol Resour, 23, 106-117. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-35951477

  25. Duan G, Wu G, Chen X, Tian D, Li Z, Sun Y, Du Z, Hao L, Song S, Gao Y, Xiao J, Zhang Z, Bao Y, Tang B and Zhao W (2023) HGD: an integrated homologous gene database across multiple species. Nucleic Acids Res, 51, D994-D1002. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36318261

  26. CNCB-NGDC Members & Partners (2023) Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023. Nucleic Acids Res, 51, D18-D28. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36420893

  27. Zhang ZW, Teng X, Zhao F, Ma C, Zhang J, Xiao LF, Wang Y, Chang M, Tian Y, Li C, Zhang Z, Song S, Tong WM, Liu P and Niu Y (2022) METTL3 regulates m(6)A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma. Cell Rep, 41, 111530. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36288719

  28. Zhang Z (2022) KaKs_Calculator 3.0: Calculating Selective Pressure on Coding and Non-coding Sequences. Genomics Proteomics Bioinformatics, 20, 536-540. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34990803

  29. Zhang Y, Zou D, Zhu T, Xu T, Chen M, Niu G, Zong W, Pan R, Jing W, Sang J, Liu C, Xiong Y, Sun Y, Zhai S, Chen H, Zhao W, Xiao J, Bao Y, Hao L and Zhang Z (2022) Gene Expression Nebulas (GEN): a comprehensive data portal integrating transcriptomic profiles across multiple species at both bulk and single-cell levels. Nucleic Acids Res, 50, D1016-D1024. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34591957

  30. Xiong Z, Yang F, Li M, Ma Y, Zhao W, Wang G, Li Z, Zheng X, Zou D, Zong W, Kang H, Jia Y, Li R, Zhang Z and Bao Y (2022) EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study. Nucleic Acids Res, 50, D1004-D1009. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718752

  31. Liu L, Zhang Y, Niu G, Li Q, Li Z, Zhu T, Feng C, Liu X, Zhang Y, Xu T, Chen R, Teng X, Zhang R, Zou D, Ma L and Zhang Z (2022) BrainBase: a curated knowledgebase for brain diseases. Nucleic Acids Res, 50, D1131-D1138. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718720

  32. Liu L, Li Z, Liu C, Zou D, Li Q, Feng C, Jing W, Luo S, Zhang Z and Ma L (2022) LncRNAWiki 2.0: a knowledgebase of human long non-coding RNAs with enhanced curation model and database system. Nucleic Acids Res, 50, D190-D195. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34751395

  33. Li R, Zhang X, Song S, Wang Y, Zou D, Xiao J, Zhao W, Zhang Z and Bao Y (2022) Safety management and application of genomics data. Big Data Research, 8, 37-45.

  34. Jiang S, Du Q, Feng C, Ma L and Zhang Z (2022) CompoDynamics: a comprehensive database for characterizing sequence composition dynamics. Nucleic Acids Res, 50, D962-D969. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718745

  35. Jia L, Li Y, Huang F, Jiang Y, Li H, Wang Z, Chen T, Li J, Zhang Z and Yao W (2022) LIRBase: a comprehensive database of long inverted repeats in eukaryotic genomes. Nucleic Acids Res, 50, D174-D182. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34643715

  36. Hua Z, Tian D, Jiang C, Song S, Chen Z, Zhao Y, Jin Y, Huang L, Zhang Z and Yuan Y (2022) Towards comprehensive integration and curation of chloroplast genomes. Plant Biotechnol J, 20, 2239-2241. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36069606

  37. CNCB-NGDC Members & Partners (2022) Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022. Nucleic Acids Res, 50, D27-D38. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718731

  38. Cao J, Zhang Y, Tan S, Yang Q, Wang H-L, Xia X, Luo J, Guo H, Zhang Z and Li Z (2022) LSD 4.0: an improved database for comparative studies of leaf senescence. Molecular Horticulture, 2, 24.

  39. Zhang SS, Chen X, Chen TT, Zhu JW, Tang BX, Wang AK, Dong LL, Zhang ZW, Sun YL, Yu CX, Zhai S, Sun YB, Chen HX, Du ZL, Xiao JF, Zhang Z, Bao YM, Wang YQ and Zhao WM (2021) GSA-Human: Genome Sequence Archive for Human. Yi Chuan, 43, 988-993. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34702711

  40. Sun C, Huang J, Wang Y, Zhao X, Su L, Thomas GWC, Zhao M, Zhang X, Jungreis I, Kellis M, Vicario S, Sharakhov IV, Bondarenko SM, Hasselmann M, Kim CN, Paten B, Penso-Dolfin L, Wang L, Chang Y, Gao Q, Ma L, Ma L, Zhang Z, Zhang H, Zhang H, Ruzzante L, Robertson HM, Zhu Y, Liu Y, Yang H, Ding L, Wang Q, Ma D, Xu W, Liang C, Itgen MW, Mee L, Cao G, Zhang Z, Sadd BM, Hahn MW, Schaack S, Barribeau SM, Williams PH, Waterhouse RM and Mueller RL (2021) Genus-Wide Characterization of Bumblebee Genomes Provides Insights into Their Evolution and Variation in Ecological and Behavioral Traits. Mol Biol Evol, 38, 486-501. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32946576

  41. RNAcentral Consortium (2021) RNAcentral 2021: secondary structure integration, improved sequence search and new member databases. Nucleic Acids Res, 49, D212-D220. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33106848

  42. Liu X, Wang P, Teng X, Zhang Z and Song S (2021) Comprehensive Analysis of Expression Regulation for RNA m6A Regulators With Clinical Significance in Human Cancers. Front Oncol, 11, 624395. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33718187

  43. Li Z, Liu L, Jiang S, Li Q, Feng C, Du Q, Zou D, Xiao J, Zhang Z and Ma L (2021) LncExpDB: an expression database of human long non-coding RNAs. Nucleic Acids Res, 49, D962-D968. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33045751

  44. Li C, Tian D, Tang B, Liu X, Teng X, Zhao W, Zhang Z and Song S (2021) Genome Variation Map: a worldwide collection of genome variations across multiple species. Nucleic Acids Res, 49, D1186-D1191. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33170268

  45. CNCB-NGDC Members & Partners (2021) Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021. Nucleic Acids Res, 49, D18-D28. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33175170

  46. Chen T, Chen X, Zhang S, Zhu J, Tang B, Wang A, Dong L, Zhang Z, Yu C, Sun Y, Chi L, Chen H, Zhai S, Sun Y, Lan L, Zhang X, Xiao J, Bao Y, Wang Y, Zhang Z and Zhao W (2021) The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types. Genomics Proteomics Bioinformatics, 19, 578-583. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34400360

  47. Chen M, Ma Y, Wu S, Zheng X, Kang H, Sang J, Xu X, Hao L, Li Z, Gong Z, Xiao J, Zhang Z, Zhao W and Bao Y (2021) Genome Warehouse: A Public Repository Housing Genome-scale Data. Genomics Proteomics Bioinformatics, 19, 584-589. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34175476

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SELECTED INVITED TALKS

  1. From data to theory: three laws of genome nucleotide composition. The 12th National Conference on Bioinformatics and System Biology of China, Qingdao, China, October 27-30, 2023.

  2. CNCB-NGDC database resources: from deposition to integration to translation. GPB Omics and Bioinformatics Frontiers Symposium 2023, Beijing, China, August 2-4, 2023.

  3. Towards a Universe of Human Long Non-coding RNAs. The 8th National Conference on Computational Biology and Bioinformatics (第八届全国计算生物学与生物信息学学术会议), Guangzhou, July 22-25, 2022.

  4. Biological Big Data Deposition, Public Sharing and Database Resources. The 10th National Conference on Bioinformatics and System Biology of China, Chengdu, October 25-29, 2021.

  5. Database Resources of the National Genomics Data Center. The 9th National Conference on Bioinformatics and System Biology of China, Shanghai, September 26-29, 2020.

  6. Computational genomics of brain tumors: glioma biomarker identification and characterization through multi-omics integrative molecular profiling. KAUST Research Conference Digital Health 2020, Thuwal, Saudi Arabia, January 20-22, 2020.

  7. Building a big data ecosystem for bioinformatics. The 4th Annual European Bioinformatics Core Community Workshop, Basel, Switzerland, 26 July 2019.

  8. 生命组学大数据管理与资源体系建设. 中国科学院青年创新促进会第一届青年生命科学论坛, 乌鲁木齐, 2019年7月12-16日.

  9. 生命组学数据资源体系建设. 第六届全国计算生物学与生物信息学学术会议, 成都, 2019年3月30-31日.

  10. Database Resources of the BIG Data Center in 2018. International Conference on Precision Medicine, Bangkok, Thailand, 19-20 July 2018.

  11. 基因大数据汇交共享与多组学数据资源体系建设. 北京生物信息学系列论坛, 北京大学, 2018年1月19日

  12. The BIG Data Center: from deposition to integration to translation. The Sino-ASEAN Conference on Precision Medicine, Burapha University, Thailand, 17-18 June 2017.

  13. The BIG Data Center’s database resources: towards precision medicine . The 10th International Biocuration Conference, Stanford University, United States, 26-29 March 2017.

  14. The BIG Data Center: from deposition to integration to translation. The 4th Youth Forum for Computer & Life Sciences Interdisciplinary Research (第四届数学、计算机与生命科学交叉研究青年学者论坛), Beijing, China, May 21-22, 2016.

  15. The BIG Data Center for Life and Health Sciences. The Phoenix City Forum for Genome Informatics (基因组信息学凤凰城论坛), Tangshan, China, May 13-15, 2016.

  16. The BIG Data Center: from deposition to integration to translation. The 9th International Biocuration Conference, Geneva, Switzerland, April 10-14, 2016.

  17. Big Data integration: scalability and sustainability. KAUST Research Conference on Computational and Experimental Interfaces of Big Data and Biotechnology, Thuwal, Saudi Arabia, Jan. 25-27, 2016.

  18. Toward Sustainability and Scalability for Big Data Integration. 2015 Functional Genomics Summit II, Beijing, China, Nov. 11-12, 2015.

  19. Community integration of big data. The 2015 International Conference of Genomics, Xi'an, China, Oct. 22-25, 2015.

  20. Bringing biocuration to China. The 1st International Coastal Biology Congress, Yantai, China, Sept. 26-30, 2014.

  21. Big data integration, curation, and analysis. The 3rd Young Bioinformatics PI Workshop, Guangzhou, China, Sept. 19-21, 2014.

  22. Biocuration in the era of big data. The Workshop on Statistical and Computational Theory and Methodology for Big Data Analysis, Banff, Canada, Feb. 9-14, 2014.

  23. Community curation in biological knowledge wikis. The 6th International Biocuration Conference, Churchill College, Cambridge, United Kingdom, April 7-10, 2013.

  24. Rewarding community-curated contributions in biological knowledge wikis. The High-throughput Sequencing Data Analysis and Approaches Workshop, Beijing, China, Dec. 5-7, 2012.

  25. Next-Generation Bioinformatics: harnessing collective resources for large-scale data manipulation, in workshop “Challenges and future of Bioinformatics: sharing insights from the Dutch and Chinese perspective”, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, China, March 19, 2012.

TRANSLATION─非官方译文

  • Nothing in biology makes sense except in the light of evolution.  ─Theodosius Dobzhansky
    明进化之光，格生命之谛。─章张（注：参鉴“明德格物”）

  • I don't think we can get a Nobel prize by what we are doing, but the Nobel prize winners know what we are doing for.  ─Alan Bleasby
    功成不必在我，功成必定有我。─章张

  • He who loves practice without theory is like the sailor who boards ship without a rudder and compass and never knows where he may cast. ─Leonardo da Vinci
    知其然而不知其所以然。─章张