A Visual Analytics Platform for Circular RNAs in Cancers



CIRI-hub is a free, user-friendly webserver designed for the customized analysis of circular RNAs (circRNAs) in both tumor and normal tissues. It provides researchers with the tools to conduct detailed comparative studies across a wide range of samples.
  •    Comprehensive Database: 

    Includes data from 2,187 tumor samples and 680 normal samples across 33 tissue types.

  •    One-Click Analysis: 

    Offers a simple, one-stop solution for analyzing individual circRNAs, lists of circRNAs, or proprietary RNA-seq data.

  •    Advanced Customization: 

    Run specific analytical steps with customized parameters to suit varied research needs.

  •    Publication-Quality Visuals: 

    Automatically generates high-quality figures from analysis data for direct use in publications.

  •    Flexible application: 

    CIRIhub is free to every users, including commerical users.

One Click

One-stop analysis for one circRNA, circRNA lists or in-house RNA-seq data.



Advanced

Customize and execute specific analytical steps with adjustable parameters.

Advanced
Sample clustering      

 Samples clustered based on mRNA or circRNA expression            
Reported circRNAs      

 circRNAs reported by circAltas,Mioncocirc and CSCD2 databases.
Type annotation

 circRNA annotation based on position of back-splicing junctions.
Conservation score

 Orthologous circRNAs and multiple conserved score for circRNAs.
Expression landscape

 circRNA expression signatures in multi-normal and tumor types.                   
DE-circRNA

 Differential expression analysis in normal and tumor tissues.
Correlation analysis

Correlation of differential expressed circRNAs and genes.
Enrichment analysis

 Gene Ontology (GO) and KEGG enrichment analysis of correlated genes.