A Visual Analytics Platform for Circular RNAs in Cancers

  • CIRI-hub is a free, user-friendly and useful webserver for customized analysis of circRNAs in tumor and normal tissues.

  • CIRI-hub integrates a compendium of 2187 tumor and 680 normal samples spanning 33 tissue types.

  • CIRI-hub automatically generates publication-quality figures from the analysis data.

One Click

One-stop analysis for one circRNA, a list of circRNAs or in-house RNA-seq data.

Advanced

Run specific analytical steps with customized parameters.                                                


Advanced
Sample clustering      

 Samples clustered based on mRNA or circRNA expression            
Reported circRNAs      

 circRNAs reported by circAltas,Mioncocirc and CSCD2 databases.
Type annotation

 circRNA annotation based on position of back-splicing junctions.
Conservation score

 Orthologous circRNAs and multiple conserved score for circRNAs.
Expression landscape

 circRNA expression signatures in multi-normal and tumor types.                   
DE-circRNA

 Differential expression analysis in normal and tumor tissues.                   
Correlation analysis

Correlation of differentially expressed circRNAs and genes across multiple tissues.
Enrichment analysis

 Gene Ontology (GO) and KEGG enrichment analysis of correlated genes.